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Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients

Acta pharmacologica Sinica, 2020-09, Vol.41 (9), p.1167-1177

2020

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A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors

Acta pharmacologica Sinica, 2022-02, Vol.43 (2), p.483-493

2022

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Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein

Acta pharmacologica Sinica, 2022-04, Vol.43 (4), p.788-796

2022

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The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1

Molecular cancer, 2018-02, Vol.17 (1), p.63-63, Article 63

2018

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Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target

British journal of pharmacology, 2015-09, Vol.172 (17), p.4303-4318

2015

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Novel Bayesian classification models for predicting compounds blocking hERG potassium channels

Acta pharmacologica Sinica, 2014-08, Vol.35 (8), p.1093-1102

2014

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P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib

Acta pharmacologica Sinica, 2022-02, Vol.43 (2), p.457-469

2022

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Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors

Acta pharmacologica Sinica, 2018-02, Vol.39 (2), p.302-310

2018

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Natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase

Acta pharmacologica Sinica, 2022-02, Vol.43 (2), p.470-482

2022

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Pharmacophore-based virtual screening versus docking-based virtual screening： a benchmark comparison against eight targets

Acta pharmacologica Sinica, 2009-12, Vol.30 (12), p.1694-1708

2009

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Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay

Acta pharmacologica Sinica, 2018-09, Vol.39 (9), p.1544-1552

2018

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Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with "short" and "long" inverse agonists

Acta pharmacologica Sinica, 2021-09, Vol.42 (9), p.1524-1534

2021

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The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations

Acta pharmacologica Sinica, 2019-06, Vol.40 (6), p.850-858

2019

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AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors

Acta pharmacologica Sinica, 2023-01, Vol.44 (1), p.1-7

2023

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Effects of Roughly Focused Extracorporeal Shock Waves Therapy on the Expressions of Bone Morphogenetic Protein-2 and Osteoprotegerin in Osteoporotic Fracture in Rats

Chinese medical journal, 2016-11, Vol.129 (21), p.2567-2575

2016

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S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton

PloS one, 2009-03, Vol.4 (3), p.e4881

2009

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Conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1

Acta pharmacologica Sinica, 2017-12, Vol.38 (12), p.1673-1682

2017

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High yield and efficient expression and purification of the human 5-HT3A receptor

Acta pharmacologica Sinica, 2015-08, Vol.36 (8), p.1024-1032

2015

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Effects of calcium carbonate on hydro-mechanical properties of bentonite

E3S web of conferences, 2020-01, Vol.198, p.1053

2020

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Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects

Acta pharmacologica Sinica, 2022-12, Vol.43 (12), p.3130-3138

2022

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A sesquiterpene quinone, dysidine, from the sponge Dysidea villosa, activates the insulin pathway through inhibition of PTPases

Acta pharmacologica Sinica, 2009-03, Vol.30 (3), p.333-345

2009

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Activating transcription factor 6 protects insulin receptor from ER stress-stimulated desensitization via p42/44 ERK pathway

Acta pharmacologica Sinica, 2011-09, Vol.32 (9), p.1138-1147

2011

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Salvicine Functions as Novel Topoisomerase II Poison by Binding to ATP Pocket

Molecular pharmacology, 2006-11, Vol.70 (5), p.1593-1601

2006

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Benzbromarone aggravates hepatic steatosis in obese individuals

Biochimica et biophysica acta. Molecular basis of disease, 2018-06, Vol.1864 (6), p.2067-2077

2018

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Natural product juglone targets three key enzymes from Helicobacter pylori： inhibition assay with crystal structure characterization

Acta pharmacologica Sinica, 2008-07, Vol.29 (7), p.870-876

2008

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Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients

A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors

Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein

The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1

Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target

Novel Bayesian classification models for predicting compounds blocking hERG potassium channels

P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib

Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors

Natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase

Pharmacophore-based virtual screening versus docking-based virtual screening： a benchmark comparison against eight targets

Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay

Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with "short" and "long" inverse agonists

The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations

AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors

Effects of Roughly Focused Extracorporeal Shock Waves Therapy on the Expressions of Bone Morphogenetic Protein-2 and Osteoprotegerin in Osteoporotic Fracture in Rats

S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton

Conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1

High yield and efficient expression and purification of the human 5-HT3A receptor

Effects of calcium carbonate on hydro-mechanical properties of bentonite

Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects

A sesquiterpene quinone, dysidine, from the sponge Dysidea villosa, activates the insulin pathway through inhibition of PTPases

Activating transcription factor 6 protects insulin receptor from ER stress-stimulated desensitization via p42/44 ERK pathway

Salvicine Functions as Novel Topoisomerase II Poison by Binding to ATP Pocket

Benzbromarone aggravates hepatic steatosis in obese individuals

Natural product juglone targets three key enzymes from Helicobacter pylori： inhibition assay with crystal structure characterization

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