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Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice

British journal of pharmacology, 2022-01, Vol.179 (1), p.46-64

2022

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Vicagrel is hydrolyzed by Raf kinase inhibitor protein in human intestine

Biopharmaceutics & drug disposition, 2022-12, Vol.43 (6), p.247-254

2022

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Enhanced responsiveness of platelets to vicagrel in IL‐10‐deficient mice through STAT3‐dependent up‐regulation of the hydrolase arylacetamide deacetylase in the intestine

British journal of pharmacology, 2019-06, Vol.176 (11), p.1717-1727

2019

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Vicagrel enhances aspirin-induced inhibition of both platelet aggregation and thrombus formation in rodents due to its decreased metabolic inactivation

Biomedicine & pharmacotherapy, 2019-07, Vol.115, p.108906, Article 108906

2019

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Human UGT2B7 is the major isoform responsible for the glucuronidation of clopidogrel carboxylate

Biopharmaceutics & drug disposition, 2018-02, Vol.39 (2), p.88-98

2018

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Multidrug Resistance-Associated Protein 3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood

Drug metabolism and disposition, 2020-10, Vol.48 (10), p.966-971

2020

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Discovery of novel aromatase inhibitors using a homogeneous time-resolved fluorescence assay

Acta pharmacologica Sinica, 2014-08, Vol.35 (8), p.1082-1092

2014

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P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a

Biochemical pharmacology, 2021-01, Vol.183, p.114313, Article 114313

2021

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Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice

Life sciences (1973), 2021-08, Vol.279, p.119268-119268, Article 119268

2021

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Choline and trimethylamine N-oxide impair metabolic activation of and platelet response to clopidogrel through activation of the NOX/ROS/Nrf2/CES1 pathway

Journal of thrombosis and haemostasis, 2023-01, Vol.21 (1), p.117-132

2023

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The Complement System and C4b-Binding Protein: A Focus on the Promise of C4BPα as a Biomarker to Predict Clopidogrel Resistance

Molecular diagnosis & therapy, 2024-03, Vol.28 (2), p.189-199

2024

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Overcoming Clopidogrel Resistance: Three Promising Novel Antiplatelet Drugs Developed in China

Journal of cardiovascular pharmacology, 2017-12, Vol.70 (6), p.356-361

2017

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Enhanced metabolic activation of and platelet response to clopidogrel in T cell-deficient mice through induction of Cyp2c and Cyp3a and inhibition of Ces1

Journal of thrombosis and haemostasis, 2023-05, Vol.21 (5), p.1322-1335

2023

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Development and validation of a UPLC–MS/MS method for simultaneous determination of vicagrel and its major metabolites in rat or human plasma: An optimized novel strategy for the stabilization of vicagrel

Journal of pharmaceutical and biomedical analysis, 2020-02, Vol.179, p.112955-112955, Article 112955

2020

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Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond

Frontiers in pharmacology, 2024-10, Vol.15

2024

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Enhanced Platelet Response to Clopidogrel in Abcc3-deficient Mice Due to Its Increased Bioactivation

Journal of cardiovascular pharmacology, 2016-12, Vol.68 (6), p.433-440

2016

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Aspirin Attenuates the Bioactivation of and Platelet Response to Vicagrel in Mice

Journal of cardiovascular pharmacology, 2018-11, Vol.72 (5), p.252-258

2018

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A method for combining Fluoro-Jade B staining and immunofluorescent staining

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2016-05, Vol.36 (5), p.671

2016

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Sex differences in the metabolic activation of and platelet response to vicagrel in mice: Androgen as a key player

Biochemical pharmacology, 2024-12, Vol.230 (Pt 1), p.116564, Article 116564

2024

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The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice

Xenobiotica, 2024-08, Vol.54 (9), p.1-11

2024

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Mrp3 Transports Clopidogrel Acyl Glucuronide from the Hepatocytes into Blood

Drug metabolism and disposition, 2018-02, Vol.46 (2), p.151-154

2018

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Mrp3 transports clopidogrel aryl glucuronide from the hepatocytes into blood

Drug metabolism and disposition, 2017-12

2017

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Discovery of novel aromatase inhibitors using a homogeneous time-resolved fluorescence assay

Acta pharmacologica Sinica, 2014-08, Vol.35 (8), p.1082

2014

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piR‐823 contributes to colorectal tumorigenesis by enhancing the transcriptional activity of HSF1

Cancer science, 2017-09, Vol.108 (9), p.1746-1756

2017

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A novel and feasible way to cultivate and purify endothelial progenitor cells from bone marrow of children with congenital heart diseases

Chinese medical journal, 2012-06, Vol.125 (11), p.1903-1907

2012

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Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice

Vicagrel is hydrolyzed by Raf kinase inhibitor protein in human intestine

Enhanced responsiveness of platelets to vicagrel in IL‐10‐deficient mice through STAT3‐dependent up‐regulation of the hydrolase arylacetamide deacetylase in the intestine

Vicagrel enhances aspirin-induced inhibition of both platelet aggregation and thrombus formation in rodents due to its decreased metabolic inactivation

Human UGT2B7 is the major isoform responsible for the glucuronidation of clopidogrel carboxylate

Multidrug Resistance-Associated Protein 3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood

Discovery of novel aromatase inhibitors using a homogeneous time-resolved fluorescence assay

P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a

Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice

Choline and trimethylamine N-oxide impair metabolic activation of and platelet response to clopidogrel through activation of the NOX/ROS/Nrf2/CES1 pathway

The Complement System and C4b-Binding Protein: A Focus on the Promise of C4BPα as a Biomarker to Predict Clopidogrel Resistance

Overcoming Clopidogrel Resistance: Three Promising Novel Antiplatelet Drugs Developed in China

Enhanced metabolic activation of and platelet response to clopidogrel in T cell-deficient mice through induction of Cyp2c and Cyp3a and inhibition of Ces1

Development and validation of a UPLC–MS/MS method for simultaneous determination of vicagrel and its major metabolites in rat or human plasma: An optimized novel strategy for the stabilization of vicagrel

Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond

Enhanced Platelet Response to Clopidogrel in Abcc3-deficient Mice Due to Its Increased Bioactivation

Aspirin Attenuates the Bioactivation of and Platelet Response to Vicagrel in Mice

A method for combining Fluoro-Jade B staining and immunofluorescent staining

Sex differences in the metabolic activation of and platelet response to vicagrel in mice: Androgen as a key player

The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice

Mrp3 Transports Clopidogrel Acyl Glucuronide from the Hepatocytes into Blood

Mrp3 transports clopidogrel aryl glucuronide from the hepatocytes into blood

Discovery of novel aromatase inhibitors using a homogeneous time-resolved fluorescence assay

piR‐823 contributes to colorectal tumorigenesis by enhancing the transcriptional activity of HSF1

A novel and feasible way to cultivate and purify endothelial progenitor cells from bone marrow of children with congenital heart diseases

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