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Antagonism of chemokine receptor CCR8 is ineffective in a primate model of asthma

Thorax, 2013-06, Vol.68 (6), p.506-512

2013

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Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Bioorganic & medicinal chemistry, 2019-07, Vol.27 (13), p.2905-2913

2019

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Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors

Bioorganic & medicinal chemistry, 2021-08, Vol.44, p.116275-116275, Article 116275

2021

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Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model

Bioorganic & medicinal chemistry letters, 2023-01, Vol.80, p.129108, Article 129108

2023

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Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

Protein science, 2010-03, Vol.19 (3), p.429-439

2010

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Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8

Journal of medicinal chemistry, 2007-02, Vol.50 (3), p.566-584

2007

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Synthesis, X-ray Structure, and Properties of Fluorocyclopropane Analogs of the Duocarmycins Incorporating the 9,9-Difluoro-1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (F2CBI) Alkylation Subunit

Journal of the American Chemical Society, 1996-09, Vol.118 (37), p.8860-8870

1996

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Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (13), p.3504-3509

2006

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Geminal Acylation with Methyl-Substituted Analogues of 1,2-Bis[(trimethylsilyl)oxy]cyclobutene

Journal of organic chemistry, 1997-12, Vol.62 (25), p.8722-8729

1997

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Lewis Acid Catalyzed Geminal Acylation Reaction of Ketones with 1,2-Bis[(trimethylsilyl)oxy]cyclobutene: Direct Formation of 2,2-Disubstituted 1,3-Cyclopentanediones

Journal of organic chemistry, 1994-03, Vol.59 (6), p.1485-1491

1994

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Formation of 2,2-disubstituted 1,3-cyclopentanediones from ketals with 1,2-bis(trimethylsilyloxy)cyclobutene

Canadian journal of chemistry, 1993-09, Vol.71 (9), p.1311-1318

1993

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Lewis acid catalyzed geminal acylation reaction of ketones with 1,2-bis((trimethylsilyl)oxy)cyclobutene : direct formation of 2,2-disubstituted 1,3-cyclopentanediones

Journal of organic chemistry, 1994-03, Vol.59 (6), p.1485-1491

1994

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Zooplankton biogeographic boundaries in the California Current System as determined from metabarcoding

PloS one, 2020-06, Vol.15 (6), p.e0235159-e0235159

2020

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Confocal Endomicroscopy Monitoring of Tumor Formation

Methods in molecular biology (Clifton, N.J.), 2023, Vol.2691, p.257

2023

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Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

Toxicological sciences, 2018-04, Vol.162 (2), p.655-666

2018

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In Vivo Models of Inflammatory Bowel Disease and Colitis-Associated Cancer

Methods in molecular biology (Clifton, N.J.), 2018, Vol.1725, p.3

2018

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Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism

Cancer research (Chicago, Ill.), 2018-03, Vol.78 (5), p.1293-1307

2018

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Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529

Science (American Association for the Advancement of Science), 2022-04, Vol.376 (6591), p.eabn8897-eabn8897

2022

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Prenatal exome sequencing analysis in fetal structural anomalies detected by ultrasonography (PAGE): a cohort study

The Lancet (British edition), 2019-02, Vol.393 (10173), p.747-757

2019

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FKBPL is associated with metabolic parameters and is a novel determinant of cardiovascular disease

Scientific reports, 2020-12, Vol.10 (1), p.21655-21655, Article 21655

2020

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Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer

Science (American Association for the Advancement of Science), 2009-03, Vol.323 (5922), p.1747-1750

2009

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An Invariant Protein That Colocalizes With VAR2CSA on Plasmodium falciparum-Infected Red Cells Binds to Chondroitin Sulfate A

The Journal of infectious diseases, 2022-06, Vol.225 (11), p.2011-2022

2022

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A family of cytokine-inducible inhibitors of signalling

Nature (London), 1997-06, Vol.387 (6636), p.917-921

1997

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Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions

JNCI : Journal of the National Cancer Institute, 2023-06, Vol.115 (6), p.712-732

2023

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Antagonism of chemokine receptor CCR8 is ineffective in a primate model of asthma

Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors

Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8

Synthesis, X-ray Structure, and Properties of Fluorocyclopropane Analogs of the Duocarmycins Incorporating the 9,9-Difluoro-1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (F2CBI) Alkylation Subunit

Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4

Geminal Acylation with Methyl-Substituted Analogues of 1,2-Bis[(trimethylsilyl)oxy]cyclobutene

Lewis Acid Catalyzed Geminal Acylation Reaction of Ketones with 1,2-Bis[(trimethylsilyl)oxy]cyclobutene: Direct Formation of 2,2-Disubstituted 1,3-Cyclopentanediones

Formation of 2,2-disubstituted 1,3-cyclopentanediones from ketals with 1,2-bis(trimethylsilyloxy)cyclobutene

Lewis acid catalyzed geminal acylation reaction of ketones with 1,2-bis((trimethylsilyl)oxy)cyclobutene : direct formation of 2,2-disubstituted 1,3-cyclopentanediones

Zooplankton biogeographic boundaries in the California Current System as determined from metabarcoding

Confocal Endomicroscopy Monitoring of Tumor Formation

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

In Vivo Models of Inflammatory Bowel Disease and Colitis-Associated Cancer

Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529

Prenatal exome sequencing analysis in fetal structural anomalies detected by ultrasonography (PAGE): a cohort study

FKBPL is associated with metabolic parameters and is a novel determinant of cardiovascular disease

Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer

An Invariant Protein That Colocalizes With VAR2CSA on Plasmodium falciparum-Infected Red Cells Binds to Chondroitin Sulfate A

A family of cytokine-inducible inhibitors of signalling

Adavosertib plus gemcitabine for platinum-resistant or platinum-refractory recurrent ovarian cancer: a double-blind, randomised, placebo-controlled, phase 2 trial

Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions

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