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Potent and Selective Non-Peptidic Inhibitors of Endothelin-Converting Enzyme-1 with Sustained Duration of Action

Journal of medicinal chemistry, 2000-02, Vol.43 (3), p.488-504

2000

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The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors

Current medicinal chemistry, 2004-11, Vol.11 (22), p.2911-2977

2004

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Role of the Endothelin System in Secondary Pulmonary Hypertension Related to Air Embolism: Lessons Learned from Testing Four Classes of Endothelin Blockers in a Rat Model

Journal of cardiovascular pharmacology, 2004-11, Vol.44 Suppl 1 (Supplement 1), p.S386-S389

2004

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Endothelin converting enzyme-1-, endothelin-1-, and endothelin-3-like immunoreactivity in the rat brain

Neuroscience, 1999-01, Vol.91 (4), p.1483-1497

1999

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The design, structure, and therapeutic application of matrix metalloproteinase inhibitors

Current medicinal chemistry, 2001-03, Vol.8 (4), p.425-474

2001

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The First Preclinical Pharmacotoxicological Safety Assessment of CGS 35601, a Triple Vasopeptidase Inhibitor, in Chronically Instrumented, Conscious, and Unrestrained Spontaneously Hypertensive Rats

Drug and chemical toxicology (New York, N.Y. 1978), 2006-01, Vol.29 (2), p.183-202

2006

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Prevention and reversal of cerebral vasospasm by an endothelin-converting enzyme inhibitor, CGS 26303, in an experimental model of subarachnoid hemorrhage

Journal of neurosurgery, 1997-08, Vol.87 (2), p.281-286

1997

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Design and Synthesis of Potent, Selective Inhibitors of Endothelin-Converting Enzyme

Journal of medicinal chemistry, 1998-04, Vol.41 (9), p.1513-1523

1998

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Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase

Bioorganic & medicinal chemistry letters, 1998-04, Vol.8 (8), p.897-902

1998

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Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action

Biochemical pharmacology, 1988-04, Vol.37 (8), p.1541-1545

1988

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Systemic administration of an inhibitor of endothelin-converting enzyme for attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage

Journal of neurosurgery, 1996-11, Vol.85 (5), p.917-922

1996

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Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney

Peptides (New York, N.Y. : 1980), 1988, Vol.9 (1), p.173-180

1988

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Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C

The Journal of clinical investigation, 1985-11, Vol.76 (5), p.1932-1938

1985

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Effect of ECE and NEP inhibition on cigarette smoke-induced cell proliferation in the rat lung

Inhalation toxicology, 2001-06, Vol.13 (6), p.497-511

2001

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Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1

Bioorganic & medicinal chemistry letters, 2000-09, Vol.10 (17), p.2037-2039

2000

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Perhydroquinolylbenzamides as Novel Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1

Journal of medicinal chemistry, 2005-10, Vol.48 (21), p.6696-6712

2005

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Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine

Acta neurochirurgica, 2002-02, Vol.144 (2), p.189-93; discussion 193

2002

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Mercaptoacyl Dipeptides as Orally Active Dual Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase

Journal of medicinal chemistry, 1996-08, Vol.39 (16), p.3158-3168

1996

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Modulation of endothelin production and metabolism in guinea-pig tracheal epithelial cells by peptidase inhibitors

American journal of respiratory and critical care medicine, 1997-06, Vol.155 (6), p.1884-1889

1997

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Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells

Cancer research (Chicago, Ill.), 1988-08, Vol.48 (16), p.4646-4650

1988

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Triple VPI CGS 35601 Reduces High Blood Pressure in Low-Renin, High-Salt Dahl Salt-Sensitive Rats

Experimental biology and medicine (Maywood, N.J.), 2006-06, Vol.231 (6), p.830-833

2006

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Effect of phospholipid on substrate phosphorylation by a catalytic fragment of protein kinase C

The Journal of biological chemistry, 1987-08, Vol.262 (24), p.11507-11513

1987

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Inhibition of Peptidylglycine .alpha.-Amidating Monooxygenase by N-Substituted Homocysteine Analogs

Journal of medicinal chemistry, 1994-12, Vol.37 (26), p.4430-4437

1994

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Isoindolines: A new series of potent and selective endothelin-A receptor antagonists

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (13), p.1737-1740

2001

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Substance P levels in experimental ileitis in guinea pigs: effects of misoprostol

American journal of physiology: Gastrointestinal and liver physiology, 1993-08, Vol.265 (2 Pt 1), p.G321-G330

1993

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Potent and Selective Non-Peptidic Inhibitors of Endothelin-Converting Enzyme-1 with Sustained Duration of Action

The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors

Role of the Endothelin System in Secondary Pulmonary Hypertension Related to Air Embolism: Lessons Learned from Testing Four Classes of Endothelin Blockers in a Rat Model

Endothelin converting enzyme-1-, endothelin-1-, and endothelin-3-like immunoreactivity in the rat brain

The design, structure, and therapeutic application of matrix metalloproteinase inhibitors

The First Preclinical Pharmacotoxicological Safety Assessment of CGS 35601, a Triple Vasopeptidase Inhibitor, in Chronically Instrumented, Conscious, and Unrestrained Spontaneously Hypertensive Rats

Prevention and reversal of cerebral vasospasm by an endothelin-converting enzyme inhibitor, CGS 26303, in an experimental model of subarachnoid hemorrhage

Design and Synthesis of Potent, Selective Inhibitors of Endothelin-Converting Enzyme

Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase

Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action

Systemic administration of an inhibitor of endothelin-converting enzyme for attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage

Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney

Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C

Effect of ECE and NEP inhibition on cigarette smoke-induced cell proliferation in the rat lung

Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1

Perhydroquinolylbenzamides as Novel Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1

Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine

Mercaptoacyl Dipeptides as Orally Active Dual Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase

Modulation of endothelin production and metabolism in guinea-pig tracheal epithelial cells by peptidase inhibitors

Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells

Triple VPI CGS 35601 Reduces High Blood Pressure in Low-Renin, High-Salt Dahl Salt-Sensitive Rats

Effect of phospholipid on substrate phosphorylation by a catalytic fragment of protein kinase C

Inhibition of Peptidylglycine .alpha.-Amidating Monooxygenase by N-Substituted Homocysteine Analogs

Isoindolines: A new series of potent and selective endothelin-A receptor antagonists

Substance P levels in experimental ileitis in guinea pigs: effects of misoprostol

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