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5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (2), p.288-292

2006

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Quantitative Structure−Activity Relationships among Macrolide Antibacterial Agents: In Vitro and in Vivo Potency against Pasteurella multocida

Journal of medicinal chemistry, 1997-04, Vol.40 (9), p.1340-1346

1997

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5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.1067-1072

2007

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Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (8), p.2076-2080

2006

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5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1202-1206

2006

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Comparative structure–activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.1042-1045

2008

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In vitro and in vivo profile of 5-[(4' -trifluoromethyl -biphenyl -2-carbonyl ) -amino]-1H -indole -2 -carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1996-1999

2007

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Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.95-98

2004

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Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (11), p.3039-3042

2006

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In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor

Bioorganic & medicinal chemistry, 2005-03, Vol.13 (5), p.1805-1809

2005

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Efficient Preparation of Hygromycin A Aglycon and Its Antibacterial 4'-Allyl Ether, CP-111905

Journal of organic chemistry, 1994-03, Vol.59 (5), p.1224-1225

1994

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A synthetic route to forskolin

Journal of the American Chemical Society, 1987-12, Vol.109 (26), p.8115-8116

1987

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Repromicin Derivatives with Potent Antibacterial Activity against Pasteurella multocida

Journal of medicinal chemistry, 1997-03, Vol.40 (6), p.1041-1045

1997

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Efficient fluoride-mediated synthesis of 5-alkyl amino- and ether-substituted pyrazoles

Tetrahedron letters, 2005-10, Vol.46 (40), p.6887-6891

2005

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Semisynthetic hygromycin A analogs: Synthesis and antibacterial activity of derivatives lacking the furanose moiety

Journal of antibiotics, 1992, Vol.45 (10), p.1705-1707

1992

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In vitro and in vivo profile of 5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1 H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (7), p.1996-1999

2007

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Rearrangement of a hindered allylic alcohol during vanadium-catalyzed epoxidation. A short synthesis of uvidin-c

Tetrahedron letters, 1985, Vol.26 (48), p.5875-5878

1985

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Semisynthetic hygromycin A analogs: synthesis and anti-bacterial activity of derivatives lacking the furanose moiety

Journal of antibiotics, 1992-10, Vol.45 (10), p.1705-1707

1992

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Formation of (±)-forskolin via a cuprate addition to a synthetic dihydropyran-4-one

Tetrahedron letters, 1988, Vol.29 (17), p.2031-2032

1988

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SEMISYNTHETIC HYGROMYCIN A ANALOGS: SYNTHESIS AND ANTI-BACTERIAL ACTIVITY OF DERIVATIVES LACKING THE FURANOSE MOIETY

The Journal of Antibiotics, 1992/10/25, Vol.45(10), pp.1705-1707

1992

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Chapter 13. Antibacterial Agents

Annual Reports in Medicinal Chemistry, 1996, Vol.31, p.121-130

1996

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Reconstitution of forskolin from a ring C dihydropyran-4-one degradation product thereof

Tetrahedron letters, 1987, Vol.28 (21), p.2339-2342

1987

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Synthesis and vitro antibacterial activity of hygromycin a analogs modified at the C 4′ aryl position

Bioorganic & medicinal chemistry letters, 1993, Vol.3 (8), p.1531-1536

1993

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Synthesis and in vitro antibacterial activity of hygromycin A analogs modified at the C4' aryl position

Bioorganic & medicinal chemistry letters, 1993-08, Vol.3 (8), p.1531-1536

1993

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Efficient Fluoride-Mediated Synthesis of 5-Alkyl Amino- and Ether-Substituted Pyrazoles

ChemInform, 2006-01, Vol.37 (3), p.no-no

2006

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5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog

Quantitative Structure−Activity Relationships among Macrolide Antibacterial Agents: In Vitro and in Vivo Potency against Pasteurella multocida

5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile

Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors

5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers

Comparative structure–activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition

In vitro and in vivo profile of 5-[(4' -trifluoromethyl -biphenyl -2-carbonyl ) -amino]-1H -indole -2 -carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity

Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine

Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents

In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor

Efficient Preparation of Hygromycin A Aglycon and Its Antibacterial 4'-Allyl Ether, CP-111905

A synthetic route to forskolin

Repromicin Derivatives with Potent Antibacterial Activity against Pasteurella multocida

Efficient fluoride-mediated synthesis of 5-alkyl amino- and ether-substituted pyrazoles

Semisynthetic hygromycin A analogs: Synthesis and antibacterial activity of derivatives lacking the furanose moiety

In vitro and in vivo profile of 5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1 H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity

Rearrangement of a hindered allylic alcohol during vanadium-catalyzed epoxidation. A short synthesis of uvidin-c

Semisynthetic hygromycin A analogs: synthesis and anti-bacterial activity of derivatives lacking the furanose moiety

Formation of (±)-forskolin via a cuprate addition to a synthetic dihydropyran-4-one

SEMISYNTHETIC HYGROMYCIN A ANALOGS: SYNTHESIS AND ANTI-BACTERIAL ACTIVITY OF DERIVATIVES LACKING THE FURANOSE MOIETY

Chapter 13. Antibacterial Agents

Reconstitution of forskolin from a ring C dihydropyran-4-one degradation product thereof

Synthesis and vitro antibacterial activity of hygromycin a analogs modified at the C 4′ aryl position

Synthesis and in vitro antibacterial activity of hygromycin A analogs modified at the C4' aryl position

Efficient Fluoride-Mediated Synthesis of 5-Alkyl Amino- and Ether-Substituted Pyrazoles

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