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Induction of osteoarthritis in the rat by surgical tear of the meniscus: Inhibition of joint damage by a matrix metalloproteinase inhibitor

Osteoarthritis and cartilage, 2002-10, Vol.10 (10), p.785-791

2002

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Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors

Osteoarthritis and cartilage, 2001-11, Vol.9 (8), p.751-760

2001

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Design, Synthesis, and Biological Evaluation of Potent Thiazine- and Thiazepine-Based Matrix Metalloproteinase Inhibitors

Journal of medicinal chemistry, 1999-11, Vol.42 (22), p.4547-4562

1999

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Potent and Selective Carboxylic Acid-Based Inhibitors of Matrix Metalloproteinases

Journal of medicinal chemistry, 2001-08, Vol.44 (16), p.2499-2502

2001

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Design, Synthesis, and Biological Evaluation of Matrix Metalloproteinase Inhibitors Derived from a Modified Proline Scaffold

Journal of medicinal chemistry, 1999-12, Vol.42 (26), p.5426-5436

1999

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Comparison of the pharmacology of hydroxamate- and carboxylate-based matrix metalloproteinase inhibitors (MMPIs) for the treatment of osteoarthritis

Inflammation research, 2006-02, Vol.55 (2), p.60-65

2006

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New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 3. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents: Variations at the 5 Position

Journal of medicinal chemistry, 1998-08, Vol.41 (18), p.3515-3529

1998

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Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors

Journal of medicinal chemistry, 2000-02, Vol.43 (3), p.369-380

2000

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Degradation of cartilage matrix proteoglycan by human neutrophils involves both elastase and cathepsin G

The Journal of immunology (1950), 1991-06, Vol.146 (11), p.3922-3928

1991

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Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration

Osteoarthritis and cartilage, 2004-09, Vol.12 (9), p.720-728

2004

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Cartilage degradation by cocultures of transformed macrophage and fibroblast cell lines. A model of metalloproteinase-mediated connective tissue degradation

The Journal of immunology (1950), 1993-03, Vol.150 (5), p.1922-1931

1993

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Isolation of a yeast heptaglucoside that inhibits monocyte phagocytosis of zymosan particles

The Journal of immunology (1950), 1989-02, Vol.142 (3), p.959-965

1989

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Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146

Inflammation research, 1997-12, Vol.46 (12), p.503-508

1997

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Pharmacology of N-[4-(4-morpholinylcarbonyl)benzoyl]-L-valyl-N- [3,3,4,4,4-pentafluoro-1-(1-methylethyl)-2-oxobutyl]-L-prolinamide (MDL 101,146): a potent orally active inhibitor of human neutrophil elastase

The Journal of pharmacology and experimental therapeutics, 1994-07, Vol.270 (1), p.185

1994

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Inhibition of Human Neutrophil Elastase. 4. Design, Synthesis, X-ray Crystallographic Analysis, and Structure−Activity Relationships for a Series of P2-Modified, Orally Active Peptidyl Pentafluoroethyl Ketones

Journal of medicinal chemistry, 1998-07, Vol.41 (14), p.2461-2480

1998

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Cartilage proteoglycan degradation by a mouse transformed macrophage cell line is mediated by macrophage metalloelastase

Inflammation research, 1999-05, Vol.48 (5), p.280-288

1999

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Pharmacological evaluation of selected, orally active, peptidyl inhibitors of human neutrophil elastase

The Journal of pharmacology and experimental therapeutics, 1995-12, Vol.275 (3), p.1233

1995

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Isolation of soluble yeast beta-glucans that inhibit human monocyte phagocytosis mediated by beta-glucan receptors

The Journal of immunology (1950), 1986-11, Vol.137 (10), p.3270-3276

1986

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High potency dipeptide sweeteners. 1. L-Aspartyl-D-phenylglycine esters

Journal of medicinal chemistry, 1990-03, Vol.33 (3), p.1052-1061

1990

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Heterocycle-based MMP Inhibitors with P2′ Substituents

Bioorganic & medicinal chemistry letters, 2001-04, Vol.11 (8), p.1009-1013

2001

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Lysosomal enzyme release from human monocytes by particulate activators is mediated by beta-glucan inhibitable receptors

The Journal of immunology (1950), 1987-06, Vol.138 (11), p.3897-3901

1987

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Phagocytosis of heat-killed blastospores of Candida albicans by human monocyte β-glucan receptors

Immunology, 1988-10, Vol.65 (2), p.181-185

1988

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The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold

Bioorganic & medicinal chemistry letters, 2001-08, Vol.11 (15), p.1975-1979

2001

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New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 2. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents: Variations of the Dihydrobenzofuran Ring

Journal of medicinal chemistry, 1998-03, Vol.41 (7), p.1124-1137

1998

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Induction of osteoarthritis in the rat by surgical tear of the meniscus: Inhibition of joint damage by a matrix metalloproteinase inhibitor

Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors

Design, Synthesis, and Biological Evaluation of Potent Thiazine- and Thiazepine-Based Matrix Metalloproteinase Inhibitors

Potent and Selective Carboxylic Acid-Based Inhibitors of Matrix Metalloproteinases

Design, Synthesis, and Biological Evaluation of Matrix Metalloproteinase Inhibitors Derived from a Modified Proline Scaffold

Comparison of the pharmacology of hydroxamate- and carboxylate-based matrix metalloproteinase inhibitors (MMPIs) for the treatment of osteoarthritis

New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 3. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents: Variations at the 5 Position

Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors

Degradation of cartilage matrix proteoglycan by human neutrophils involves both elastase and cathepsin G

Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration

Cartilage degradation by cocultures of transformed macrophage and fibroblast cell lines. A model of metalloproteinase-mediated connective tissue degradation

Isolation of a yeast heptaglucoside that inhibits monocyte phagocytosis of zymosan particles

Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146

Pharmacology of N-[4-(4-morpholinylcarbonyl)benzoyl]-L-valyl-N- [3,3,4,4,4-pentafluoro-1-(1-methylethyl)-2-oxobutyl]-L-prolinamide (MDL 101,146): a potent orally active inhibitor of human neutrophil elastase

Inhibition of Human Neutrophil Elastase. 4. Design, Synthesis, X-ray Crystallographic Analysis, and Structure−Activity Relationships for a Series of P2-Modified, Orally Active Peptidyl Pentafluoroethyl Ketones

Cartilage proteoglycan degradation by a mouse transformed macrophage cell line is mediated by macrophage metalloelastase

Pharmacological evaluation of selected, orally active, peptidyl inhibitors of human neutrophil elastase

Isolation of soluble yeast beta-glucans that inhibit human monocyte phagocytosis mediated by beta-glucan receptors

High potency dipeptide sweeteners. 1. L-Aspartyl-D-phenylglycine esters

Heterocycle-based MMP Inhibitors with P2′ Substituents

Lysosomal enzyme release from human monocytes by particulate activators is mediated by beta-glucan inhibitable receptors

Phagocytosis of heat-killed blastospores of Candida albicans by human monocyte β-glucan receptors

The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold

New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 2. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents: Variations of the Dihydrobenzofuran Ring

New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 1. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents: Discovery and Variation of the 5-Keto Substituent

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