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Advances and Challenges of HDAC Inhibitors in Cancer Therapeutics

Advances in cancer research, 2018, Vol.138, p.183-211

2018

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Comparison of three zinc binding groups for HDAC inhibitors – A potency, selectivity and enzymatic kinetics study

Bioorganic & medicinal chemistry letters, 2022-08, Vol.70, p.128797-128797, Article 128797

2022

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Extracellular vesicle-mediated long-range communication in stressed retinal pigment epithelial cell monolayers

Biochimica et biophysica acta. Molecular basis of disease, 2018-08, Vol.1864 (8), p.2610-2622

2018

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Silver-Catalyzed Direct Thiolation of Quinones by Activation of Aryl Disulfides to Synthesize Quinonyl Aryl Thioethers

Journal of organic chemistry, 2015-05, Vol.80 (10), p.4919-4927

2015

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Development of peptide-functionalized synthetic hydrogel microarrays for stem cell and tissue engineering applications

Acta biomaterialia, 2016-11, Vol.45, p.110-120

2016

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Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model

PloS one, 2010-01, Vol.5 (1), p.e8825

2010

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Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia

Journal of medicinal chemistry, 2016-11, Vol.59 (21), p.9942-9959

2016

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Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies

Journal of medicinal chemistry, 2019-04, Vol.62 (8), p.3898-3923

2019

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Short Laminin Peptide for Improved Neural Stem Cell Growth

Stem cells translational medicine, 2014-05, Vol.3 (5), p.662-670

2014

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Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer’s Disease Mouse Model

Journal of medicinal chemistry, 2021-04, Vol.64 (7), p.3794-3812

2021

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Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms

Gastroenterology (New York, N.Y. 1943), 2022-11, Vol.163 (5), p.1377-1390.e11

2022

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Pimelic Diphenylamide 106 Is a Slow, Tight-binding Inhibitor of Class I Histone Deacetylases

The Journal of biological chemistry, 2008-12, Vol.283 (51), p.35402-35409

2008

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Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer’s disease: Design, synthesis, and biological evaluation

Bioorganic chemistry, 2020-05, Vol.98, p.103721, Article 103721

2020

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Development of selective HDAC6 inhibitors with in vitro and in vivo anti-multiple myeloma activity

Bioorganic chemistry, 2021-11, Vol.116, p.105278-105278, Article 105278

2021

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Development of a Bestatin-SAHA Hybrid with Dual Inhibitory Activity against APN and HDAC

Molecules (Basel, Switzerland), 2020-10, Vol.25 (21), p.4991

2020

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LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a

Frontiers in pharmacology, 2024-05, Vol.15, p.1386238-1386238

2024

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Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups

Bioorganic & medicinal chemistry, 2017-06, Vol.25 (12), p.2981-2994

2017

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Structure–Activity Relationship Study of Vitamin K Derivatives Yields Highly Potent Neuroprotective Agents

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.1007-1022

2013

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Randomized, Placebo-Controlled Trial of Olanzapine as Maintenance Therapy in Patients With Bipolar I Disorder Responding to Acute Treatment With Olanzapine

The American journal of psychiatry, 2006-02, Vol.163 (2), p.247-256

2006

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Targeted multiplex validation of CSF proteomic biomarkers: implications for differentiation of PCNSL from tumor-free controls and other brain tumors

Frontiers in immunology, 2024-08, Vol.15, p.1343109

2024

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Altered expression of the L-arginine/nitric oxide pathway in ovarian cancer: metabolic biomarkers and biological implications

BMC cancer, 2023-09, Vol.23 (1), p.1-844, Article 844

2023

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Synthesis and biological study of class I selective HDAC inhibitors with NO releasing activity

Bioorganic chemistry, 2020-11, Vol.104, p.104235, Article 104235

2020

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Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer’s disease

Bioorganic chemistry, 2020-10, Vol.103, p.104109, Article 104109

2020

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Acetylation preserves retinal ganglion cell structure and function in a chronic model of ocular hypertension

Investigative ophthalmology & visual science, 2014-11, Vol.55 (11), p.7486-7493

2014

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Inhibition of class I histone deacetylase activity represses matrix metalloproteinase-2 and -9 expression and preserves LV function postmyocardial infarction

American journal of physiology. Heart and circulatory physiology, 2015-06, Vol.308 (11), p.H1391-H1401

2015

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Advances and Challenges of HDAC Inhibitors in Cancer Therapeutics

Comparison of three zinc binding groups for HDAC inhibitors – A potency, selectivity and enzymatic kinetics study

Extracellular vesicle-mediated long-range communication in stressed retinal pigment epithelial cell monolayers

Silver-Catalyzed Direct Thiolation of Quinones by Activation of Aryl Disulfides to Synthesize Quinonyl Aryl Thioethers

Development of peptide-functionalized synthetic hydrogel microarrays for stem cell and tissue engineering applications

Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model

Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia

Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies

Short Laminin Peptide for Improved Neural Stem Cell Growth

Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer’s Disease Mouse Model

Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms

Pimelic Diphenylamide 106 Is a Slow, Tight-binding Inhibitor of Class I Histone Deacetylases

Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer’s disease: Design, synthesis, and biological evaluation

Development of selective HDAC6 inhibitors with in vitro and in vivo anti-multiple myeloma activity

Development of a Bestatin-SAHA Hybrid with Dual Inhibitory Activity against APN and HDAC

LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a

Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups

Structure–Activity Relationship Study of Vitamin K Derivatives Yields Highly Potent Neuroprotective Agents

Randomized, Placebo-Controlled Trial of Olanzapine as Maintenance Therapy in Patients With Bipolar I Disorder Responding to Acute Treatment With Olanzapine

Targeted multiplex validation of CSF proteomic biomarkers: implications for differentiation of PCNSL from tumor-free controls and other brain tumors

Altered expression of the L-arginine/nitric oxide pathway in ovarian cancer: metabolic biomarkers and biological implications

Synthesis and biological study of class I selective HDAC inhibitors with NO releasing activity

Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer’s disease

Acetylation preserves retinal ganglion cell structure and function in a chronic model of ocular hypertension

Inhibition of class I histone deacetylase activity represses matrix metalloproteinase-2 and -9 expression and preserves LV function postmyocardial infarction

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