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Membrane Proteases and Aminoglycoside Antibiotic Resistance

Journal of Bacteriology, 2011-09, Vol.193 (18), p.4790-4797

2011

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In Vivo Outcome of Homology-Directed Repair at the HBB Gene in HSC Using Alternative Donor Template Delivery Methods

Molecular therapy. Nucleic acids, 2019-09, Vol.17, p.277-288

2019

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Tapping natural reservoirs of homing endonucleases for targeted gene modification

Proceedings of the National Academy of Sciences - PNAS, 2011-08, Vol.108 (32), p.13077-13082

2011

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TALEN-Mediated Gene Editing of HBG in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction

Molecular therapy. Methods & clinical development, 2019-03, Vol.12, p.175-183

2019

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pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences

Molecular therapy. Nucleic acids, 2016, Vol.5 (4), p.e306-e306, Article e306

2016

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Non-viral precision T cell receptor replacement for personalized cell therapy

Nature (London), 2023-03, Vol.615 (7953), p.687-696

2023

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Abstract 895: Coexpression of MHC class I-restricted neoTCRs and ectopic CD8 receptors in precision genome engineered CD4 T cells significantly potentiates antigen-specific effector functions

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.895-895

2020

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Abstract 2192: Non-viral genome engineering method allows highly efficient, single-step removal and precise insertion of multiple large genes

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.2192-2192

2020

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Neoantigen-targeted CD8 + T cell responses with PD-1 blockade therapy

Nature (London), 2023-03, Vol.615 (7953), p.697-704

2023

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Abstract 1526: Single-step precision genome engineering platform enables versatile generation of personalized (neoTCR) adoptive cell therapy T cells with supplementary anti-tumor attributes

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1526-1526

2021

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Characterization of homing endonuclease binding and cleavage specificities using yeast surface display SELEX (YSD-SELEX)

Nucleic acids research, 2017-02, Vol.45 (3), p.e11

2017

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Abstract 2177: Tumor neoantigen profiling with validated patient-specific TCR characterization to improve neoepitope prediction

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.2177-2177

2021

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Coupling endonucleases with DNA end-processing enzymes to drive gene disruption

Nature methods, 2012-10, Vol.9 (10), p.973

2012

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Contact‐dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB

Molecular microbiology, 2008-10, Vol.70 (2), p.323-340

2008

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Abstract 1433: NeoTCR-P1, a novel neoepitope-specific adoptive cell therapy, consists of T cells with ‘younger’ phenotypes that rapidly proliferate and kill target cells upon recognition of cognate antigen

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.1433-1433

2019

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Abstract 4783: Highly efficient, non-viral precision genome engineering for the generation of personalized neoepitope-specific adoptive T cell therapies

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.4783-4783

2019

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Abstract NG11: Landscape analysis of neoepitope-specific T-cell responses to immunotherapy

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.NG11-NG11

2020

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Talen Mediated Therapeutic Gene Editing Strategy for ß-Hemoglobinopathies

Blood, 2017-12, Vol.130, p.3340-3340

2017

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High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k “Helper” Proteins

Molecular therapy, 2016-09, Vol.24 (9), p.1570-1580

2016

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Abstract 2827: Non-viral gene editing enables multiplex single-step precision genome engineering for adoptive cell therapies

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2827-2827

2022

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Abstract 1435: An ultra-sensitive and high-throughput technology (imPACT) for the identification and isolation of intrinsic and emergent neoepitope-specific T cells from the peripheral blood and TILs of cancer patients

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.1435-1435

2019

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Abstract 2829: Non-viral precision genome engineering enables personalized adoptive neoTCR T cell therapy for cancer including multiple additional edits that improve the activity of neoTCR T cells by enhancing CD4 T cell antigen sensitivity and conferring resistance to TGFβ

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2829-2829

2022

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Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space

Nucleic acids research, 2012-06, Vol.40 (11), p.4954

2012

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Discovering and Characterizing New Homing Endonucleases for Genome Engineering

Jacoby, Kyle M

2013

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ProQuest

Homing endonuclease target determination using SELEX adapted for yeast surface display

Methods in molecular biology (Clifton, N.J.), 2014, Vol.1123, p.165

2014

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Membrane Proteases and Aminoglycoside Antibiotic Resistance

In Vivo Outcome of Homology-Directed Repair at the HBB Gene in HSC Using Alternative Donor Template Delivery Methods

Tapping natural reservoirs of homing endonucleases for targeted gene modification

TALEN-Mediated Gene Editing of HBG in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction

pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences

Non-viral precision T cell receptor replacement for personalized cell therapy

Abstract 895: Coexpression of MHC class I-restricted neoTCRs and ectopic CD8 receptors in precision genome engineered CD4 T cells significantly potentiates antigen-specific effector functions

Abstract 2192: Non-viral genome engineering method allows highly efficient, single-step removal and precise insertion of multiple large genes

Neoantigen-targeted CD8 + T cell responses with PD-1 blockade therapy

Abstract 1526: Single-step precision genome engineering platform enables versatile generation of personalized (neoTCR) adoptive cell therapy T cells with supplementary anti-tumor attributes

Characterization of homing endonuclease binding and cleavage specificities using yeast surface display SELEX (YSD-SELEX)

Abstract 2177: Tumor neoantigen profiling with validated patient-specific TCR characterization to improve neoepitope prediction

Coupling endonucleases with DNA end-processing enzymes to drive gene disruption

Contact‐dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB

Abstract 1433: NeoTCR-P1, a novel neoepitope-specific adoptive cell therapy, consists of T cells with ‘younger’ phenotypes that rapidly proliferate and kill target cells upon recognition of cognate antigen

Abstract 4783: Highly efficient, non-viral precision genome engineering for the generation of personalized neoepitope-specific adoptive T cell therapies

Abstract NG11: Landscape analysis of neoepitope-specific T-cell responses to immunotherapy

Talen Mediated Therapeutic Gene Editing Strategy for ß-Hemoglobinopathies

High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k “Helper” Proteins

Abstract 2827: Non-viral gene editing enables multiplex single-step precision genome engineering for adoptive cell therapies

Abstract 1435: An ultra-sensitive and high-throughput technology (imPACT) for the identification and isolation of intrinsic and emergent neoepitope-specific T cells from the peripheral blood and TILs of cancer patients

Abstract 2829: Non-viral precision genome engineering enables personalized adoptive neoTCR T cell therapy for cancer including multiple additional edits that improve the activity of neoTCR T cells by enhancing CD4 T cell antigen sensitivity and conferring resistance to TGFβ

Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space

Discovering and Characterizing New Homing Endonucleases for Genome Engineering

Homing endonuclease target determination using SELEX adapted for yeast surface display

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