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Regioselective Preparation of 2-Substituted 3,4-Diaryl Pyrroles: A Concise Total Synthesis of Ningalin B

Journal of organic chemistry, 2002-12, Vol.67 (26), p.9439-9442

2002

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Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury

Nature medicine, 1999-12, Vol.5 (12), p.1396-1402

1999

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Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein–Protein Interaction

Journal of medicinal chemistry, 2017-04, Vol.60 (8), p.3511-3517

2017

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Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3

European journal of medicinal chemistry, 2024-10, Vol.276, p.116677, Article 116677

2024

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Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4

Journal of medicinal chemistry, 2023-03, Vol.66 (5), p.3540-3565

2023

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Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4

Journal of medicinal chemistry, 2024-08, Vol.67 (16), p.14493-14523

2024

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Adenosine A(2A) Receptor Antagonists and Parkinson's Disease

ACS chemical neuroscience, 2011-10, Vol.2 (10), p.555

2011

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Adenosine A2A Receptor Antagonists and Parkinson’s Disease

ACS chemical neuroscience, 2011-06, Vol.2 (10), p.555-567

2011

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Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

Bioorganic chemistry, 2021-10, Vol.115, p.105244-105244, Article 105244

2021

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7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex

ACS infectious diseases, 2023-03, Vol.9 (3), p.668-691

2023

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Microwave-assisted Sonogashira-type cross couplings of various heterocyclic methylthioethers

Tetrahedron letters, 2009-03, Vol.50 (9), p.1013-1015

2009

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7‑N‑Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc 1 Complex

ACS infectious diseases, 2023-03, Vol.9 (3), p.668-691

2023

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Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate

Chemical research in toxicology, 2011-07, Vol.24 (7), p.1012

2011

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In Vivo Characterization of a Dual Adenosine A2A/A1 Receptor Antagonist in Animal Models of Parkinson’s Disease

Journal of medicinal chemistry, 2010-11, Vol.53 (22), p.8104-8115

2010

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Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists

Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (9), p.2688-2691

2013

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JNJ-40255293, a Novel Adenosine A2A/A1 Antagonist with Efficacy in Preclinical Models of Parkinson’s Disease

ACS chemical neuroscience, 2014-10, Vol.5 (10), p.1005-1019

2014

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Pyridinylimidazole based p38 MAP kinase inhibitors

Current topics in medicinal chemistry, 2002-09, Vol.2 (9), p.1011

2002

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Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs)

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (1), p.405-408

2008

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Design of NAALADase inhibitors: a novel neuroprotective strategy

Current medicinal chemistry, 2001-07, Vol.8 (8), p.949

2001

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Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (9), p.2864-2867

2010

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1-Hydroxy-2-pyridinone-based MMP inhibitors: Synthesis and biological evaluation for the treatment of ischemic stroke

Bioorganic & medicinal chemistry, 2008, Vol.18 (1), p.409-413

2008

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Methylene amine substituted arylindenopyrimidines as potent adenosine A2A/A1 antagonists

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (9), p.2864-2867

2010

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Synthesis and Biological Evaluation of Thiol-Based Inhibitors of Glutamate Carboxypeptidase II: Discovery of an Orally Active GCP II Inhibitor

Journal of medicinal chemistry, 2003-05, Vol.46 (10), p.1989-1996

2003

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Design and Pharmacological Activity of Phosphinic Acid Based NAALADase Inhibitors

Journal of medicinal chemistry, 2001-11, Vol.44 (24), p.4170-4175

2001

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Regioselective Preparation of 2-Substituted 3,4-Diaryl Pyrroles: A Concise Total Synthesis of Ningalin B

Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury

Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein–Protein Interaction

Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4

Adenosine A(2A) Receptor Antagonists and Parkinson's Disease

Adenosine A2A Receptor Antagonists and Parkinson’s Disease

Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex

Microwave-assisted Sonogashira-type cross couplings of various heterocyclic methylthioethers

7‑N‑Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc 1 Complex

Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate

In Vivo Characterization of a Dual Adenosine A2A/A1 Receptor Antagonist in Animal Models of Parkinson’s Disease

Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists

JNJ-40255293, a Novel Adenosine A2A/A1 Antagonist with Efficacy in Preclinical Models of Parkinson’s Disease

Pyridinylimidazole based p38 MAP kinase inhibitors

Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs)

Design of NAALADase inhibitors: a novel neuroprotective strategy

Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists

1-Hydroxy-2-pyridinone-based MMP inhibitors: Synthesis and biological evaluation for the treatment of ischemic stroke

Methylene amine substituted arylindenopyrimidines as potent adenosine A2A/A1 antagonists

Synthesis and Biological Evaluation of Thiol-Based Inhibitors of Glutamate Carboxypeptidase II: Discovery of an Orally Active GCP II Inhibitor

Design and Pharmacological Activity of Phosphinic Acid Based NAALADase Inhibitors

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