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Muscarinic and Nicotinic Acetylcholine Receptor Agonists and Allosteric Modulators for the Treatment of Schizophrenia

Neuropsychopharmacology (New York, N.Y.), 2012-01, Vol.37 (1), p.16-42

2012

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Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

Trends in pharmacological sciences (Regular ed.), 2009-01, Vol.30 (1), p.25-31

2009

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M1-selective muscarinic allosteric modulation enhances cognitive flexibility and effective salience in nonhuman primates

Proceedings of the National Academy of Sciences - PNAS, 2023-05, Vol.120 (18), p.e2216792120

2023

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Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

Trends in pharmacological sciences (Regular ed.), 2009-03, Vol.30 (3), p.148-155

2009

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Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

Neuron (Cambridge, Mass.), 2016-09, Vol.91 (6), p.1244-1252

2016

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Muscarinic receptor pharmacology and circuitry for the modulation of cognition

Handbook of experimental pharmacology, 2012 (208), p.121

2012

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Classics in Chemical Neuroscience: Xanomeline

ACS chemical neuroscience, 2017-03, Vol.8 (3), p.435-443

2017

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Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Neuropsychopharmacology (New York, N.Y.), 2014-06, Vol.39 (7), p.1578-1593

2014

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Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders

Genes, brain and behavior, 2020-09, Vol.19 (7), p.e12654-n/a

2020

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The Role of Estrogen in Brain and Cognitive Aging

Neurotherapeutics, 2019-07, Vol.16 (3), p.649-665

2019

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Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist

Neuropharmacology, 2015-08, Vol.95, p.121-129

2015

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Discovery, Structure–Activity Relationship, and Biological Characterization of a Novel Series of 6‑((1H‑Pyrazolo[4,3‑b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4)

Journal of medicinal chemistry, 2019-01, Vol.62 (1), p.342-358

2019

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Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

The Journal of pharmacology and experimental therapeutics, 2008-12, Vol.327 (3), p.941

2008

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Allosteric activation of M₄ muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (45), p.14078-14083

2015

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Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

ACS chemical neuroscience, 2014-10, Vol.5 (10), p.920-942

2014

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Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Molecular pharmacology, 2008-11, Vol.74 (5), p.1345-1358

2008

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Challenges in the development of an M 4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

Bioorganic & medicinal chemistry letters, 2017-01, Vol.27 (2), p.171-175

2017

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Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice

The Journal of pharmacology and experimental therapeutics, 2006-07, Vol.318 (1), p.173-185

2006

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Partial mGlu5 Negative Allosteric Modulator M-5MPEP Demonstrates Antidepressant-Like Effects on Sleep Without Affecting Cognition or Quantitative EEG

Frontiers in neuroscience, 2021-07, Vol.15

2021

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A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning

Molecular pharmacology, 2009-08, Vol.76 (2), p.356-368

2009

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Challenges in the development of an M 4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides

Bioorganic & medicinal chemistry letters, 2017-07, Vol.27 (13), p.2990-2995

2017

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Design and Synthesis of N‑Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs

ACS medicinal chemistry letters, 2017-09, Vol.8 (9), p.925-930

2017

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Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents

The Journal of pharmacology and experimental therapeutics, 2005-02, Vol.312 (2), p.726-732

2005

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Discovery of the First Highly M5-Preferring Muscarinic Acetylcholine Receptor Ligand, an M5 Positive Allosteric Modulator Derived from a Series of 5-Trifluoromethoxy N-Benzyl Isatins

Journal of medicinal chemistry, 2009-06, Vol.52 (11), p.3445-3448

2009

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Promise of mGluR2 3 activators in psychiatry

Neuropsychopharmacology (New York, N.Y.), 2009-01, Vol.34 (1), p.248-249

2009

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Muscarinic and Nicotinic Acetylcholine Receptor Agonists and Allosteric Modulators for the Treatment of Schizophrenia

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

M1-selective muscarinic allosteric modulation enhances cognitive flexibility and effective salience in nonhuman primates

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

Muscarinic receptor pharmacology and circuitry for the modulation of cognition

Classics in Chemical Neuroscience: Xanomeline

Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders

The Role of Estrogen in Brain and Cognitive Aging

Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist

Discovery, Structure–Activity Relationship, and Biological Characterization of a Novel Series of 6‑((1H‑Pyrazolo[4,3‑b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4)

Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

Allosteric activation of M₄ muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice

Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Challenges in the development of an M 4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice

Partial mGlu5 Negative Allosteric Modulator M-5MPEP Demonstrates Antidepressant-Like Effects on Sleep Without Affecting Cognition or Quantitative EEG

A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning

Challenges in the development of an M 4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides

Design and Synthesis of N‑Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs

Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents

Discovery of the First Highly M5-Preferring Muscarinic Acetylcholine Receptor Ligand, an M5 Positive Allosteric Modulator Derived from a Series of 5-Trifluoromethoxy N-Benzyl Isatins

Promise of mGluR2 3 activators in psychiatry

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