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Effects of the dopamine D2 allosteric modulator, PAOPA, on the expression of GRK2, arrestin-3, ERK1/2, and on receptor internalization

PloS one, 2013-08, Vol.8 (8), p.e70736

2013

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Development of peptidomimetic ligands of Pro-Leu-Gly-NH2 as allosteric modulators of the dopamine D2 receptor

Beilstein journal of organic chemistry, 2013-01, Vol.9 (1), p.204-214

2013

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Modulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog

The Journal of pharmacology and experimental therapeutics, 2005-12, Vol.315 (3), p.1228-1236

2005

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Ligand-induced expansion of the S1′ site in the anthrax toxin lethal factor

FEBS letters, 2015-12, Vol.589 (24), p.3836-3841

2015

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Change in expression of vesicular protein synapsin II by chronic treatment with D2 allosteric modulator PAOPA

Peptides (New York, N.Y. : 1980), 2015-04, Vol.66, p.58-62

2015

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Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: Examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia

Peptides (New York, N.Y. : 1980), 2013-04, Vol.42, p.89-96

2013

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Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding

Acta crystallographica. Section D, Biological crystallography., 2014-11, Vol.70 (11), p.2813-2822

2014

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Probing the S2′ Subsite of the Anthrax Toxin Lethal Factor Using Novel N‑Alkylated Hydroxamates

Journal of medicinal chemistry, 2015-11, Vol.58 (21), p.8723-8733

2015

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PAOPA, a potent dopamine D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia

European neuropsychopharmacology, 2013-03, Vol.23 (3), p.253-262

2013

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Transformation of Pro-Leu-Gly-NH2 Peptidomimetic Positive Allosteric Modulators of the Dopamine D2 Receptor into Negative Modulators

ACS chemical neuroscience, 2012-04, Vol.3 (4), p.274-284

2012

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Allosteric Modulation of the Dopamine Receptor by Conformationally Constrained Type VI β-Turn Peptidomimetics of Pro-Leu-Gly-NH2

Journal of medicinal chemistry, 2007-12, Vol.50 (26), p.6725-6729

2007

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Specific binding of photoaffinity-labeling peptidomimetics of Pro-Leu-Gly-NH2 to the dopamine D2L receptor: Evidence for the allosteric modulation of the dopamine receptor

European journal of pharmacology, 2010-09, Vol.641 (2-3), p.96-101

2010

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Synthesis of Pipecolic Acid-Based Spiro Bicyclic Lactam Scaffolds as β-Turn Mimics

Journal of organic chemistry, 2005-07, Vol.70 (15), p.5954-5963

2005

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Design and Synthesis of Photoaffinity-Labeling Ligands of the l-Prolyl-l-leucylglycinamide Binding Site Involved in the Allosteric Modulation of the Dopamine Receptor

Journal of medicinal chemistry, 2006-01, Vol.49 (1), p.307-317

2006

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Short Stereoselective Synthesis of α-Substituted γ-Lactams

Journal of organic chemistry, 2006-03, Vol.71 (5), p.2151-2154

2006

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Concerted Synthesis of a Spirobicyclic Type-VI β-Turn Mimic of Pro-Pro-Pro-NH2

Organic letters, 2006-03, Vol.8 (5), p.983-986

2006

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Allosteric Modulation of the Dopamine D2 Receptor by Pro-Leu-Gly-NH2 Peptidomimetics Constrained in Either a Polyproline II Helix or a Type II β-Turn Conformation

Journal of medicinal chemistry, 2009-04, Vol.52 (7), p.2043-2051

2009

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Synthesis and Dopamine Receptor Modulating Activity of 3-Substituted γ-Lactam Peptidomimetics of l-Prolyl-l-leucyl-glycinamide

Journal of medicinal chemistry, 2003-02, Vol.46 (5), p.727-733

2003

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Stereoselective Synthesis of α,α‘-Biprolines

Organic letters, 2005-01, Vol.7 (1), p.35-38

2005

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MIF-1 and its peptidomimetic analogs attenuate haloperidol-induced vacuous chewing movements and modulate apomorphine-induced rotational behavior in 6-hydroxydopamine-lesioned rats

Peptides (New York, N.Y. : 1980), 2007-10, Vol.28 (10), p.2009-2015

2007

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2,3-Ethylene- and 2,3-trimethylene-bridged analogues of the group III metabotropic glutamate receptor ligand 2-amino-4-phosphonobutanoic acid

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (1), p.57-60

2005

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Synthesis and chemical properties of tetrazole peptide analogs

Journal of organic chemistry, 1987-05, Vol.52 (10), p.2051-2059

1987

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Determinants of postnatal weight in infant rhesus monkeys: Implications for the study of interindividual differences in neonatal growth

American journal of physical anthropology, 1995-11, Vol.98 (3), p.343-353

1995

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Dopamine receptor modulation by conformationally constrained analogs of Pro-Leu-Gly-NH2

Journal of medicinal chemistry, 1988-07, Vol.31 (7), p.1430-1436

1988

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Design, Synthesis, and Dopamine Receptor Modulating Activity of Spiro Bicyclic Peptidomimetics of l-Prolyl-l-leucyl-glycinamide

Journal of medicinal chemistry, 1999-02, Vol.42 (4), p.628-637

1999

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Effects of the dopamine D2 allosteric modulator, PAOPA, on the expression of GRK2, arrestin-3, ERK1/2, and on receptor internalization

Development of peptidomimetic ligands of Pro-Leu-Gly-NH2 as allosteric modulators of the dopamine D2 receptor

Modulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog

Ligand-induced expansion of the S1′ site in the anthrax toxin lethal factor

Change in expression of vesicular protein synapsin II by chronic treatment with D2 allosteric modulator PAOPA

Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: Examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia

Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding

Probing the S2′ Subsite of the Anthrax Toxin Lethal Factor Using Novel N‑Alkylated Hydroxamates

PAOPA, a potent dopamine D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia

Transformation of Pro-Leu-Gly-NH2 Peptidomimetic Positive Allosteric Modulators of the Dopamine D2 Receptor into Negative Modulators

Allosteric Modulation of the Dopamine Receptor by Conformationally Constrained Type VI β-Turn Peptidomimetics of Pro-Leu-Gly-NH2

Specific binding of photoaffinity-labeling peptidomimetics of Pro-Leu-Gly-NH2 to the dopamine D2L receptor: Evidence for the allosteric modulation of the dopamine receptor

Synthesis of Pipecolic Acid-Based Spiro Bicyclic Lactam Scaffolds as β-Turn Mimics

Design and Synthesis of Photoaffinity-Labeling Ligands of the l-Prolyl-l-leucylglycinamide Binding Site Involved in the Allosteric Modulation of the Dopamine Receptor

Short Stereoselective Synthesis of α-Substituted γ-Lactams

Concerted Synthesis of a Spirobicyclic Type-VI β-Turn Mimic of Pro-Pro-Pro-NH2

Allosteric Modulation of the Dopamine D2 Receptor by Pro-Leu-Gly-NH2 Peptidomimetics Constrained in Either a Polyproline II Helix or a Type II β-Turn Conformation

Synthesis and Dopamine Receptor Modulating Activity of 3-Substituted γ-Lactam Peptidomimetics of l-Prolyl-l-leucyl-glycinamide

Stereoselective Synthesis of α,α‘-Biprolines

MIF-1 and its peptidomimetic analogs attenuate haloperidol-induced vacuous chewing movements and modulate apomorphine-induced rotational behavior in 6-hydroxydopamine-lesioned rats

2,3-Ethylene- and 2,3-trimethylene-bridged analogues of the group III metabotropic glutamate receptor ligand 2-amino-4-phosphonobutanoic acid

Synthesis and chemical properties of tetrazole peptide analogs

Determinants of postnatal weight in infant rhesus monkeys: Implications for the study of interindividual differences in neonatal growth

Dopamine receptor modulation by conformationally constrained analogs of Pro-Leu-Gly-NH2

Design, Synthesis, and Dopamine Receptor Modulating Activity of Spiro Bicyclic Peptidomimetics of l-Prolyl-l-leucyl-glycinamide

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