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The Critical Path Initiative: Leveraging Collaborations to Enhance Regulatory Science

Clinical pharmacology and therapeutics, 2012-03, Vol.91 (3), p.380-383

2012

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Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

Nature (London), 1984-10, Vol.311 (5985), p.464-467

1984

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Stability of domoic acid in saline dosing solutions

Journal of AOAC International, 2000-03, Vol.83 (2), p.411-412

Johannessen, J N

2000

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3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys

The Journal of pharmacology and experimental therapeutics, 1989-06, Vol.249 (3), p.713

1989

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Domoic acid: Neurobehavioral and neurohistological effects of low-dose exposure in adult rats

Neurotoxicology and teratology, 1996-11, Vol.18 (6), p.659-670

1996

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A model of chronic neurotoxicity : long-term retention of the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) within catecholaminergic neurons

Neurotoxicology (Park Forest South), 1991, Vol.12 (2), p.285-302

JOHANNESSEN, J. N

1991

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Virtual Neuropathology: Three-Dimensional Visualization of Lesions Due to Toxic Insult

Toxicologic pathology, 2000-01, Vol.28 (1), p.100-104

2000

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Neurohistochemical biomarkers of the marine neurotoxicant, domoic acid

Neurotoxicology and teratology, 2005-09, Vol.27 (5), p.745-752

2005

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Neurotoxic damage to the nigrostriatal system in rats following intranigral administration of MPDP+ and MPP

Journal of Neural Transmission, 1988-06, Vol.74 (2), p.75-86

1988

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Saxitoxin Puffer Fish Poisoning in the United States, with the First Report of Pyrodinium bahamense as the Putative Toxin Source

Environmental health perspectives, 2006-10, Vol.114 (10), p.1502-1507

2006

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Biomarkers used to assess the effect of dietary xylitol or sorbitol in the rat

Nutrition research (New York, N.Y.), 1999-11, Vol.19 (11), p.1637-1648

1999

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Age‐Dependent Sensitivity of Cultured Peripheral Sympathetic Neurons to 1‐Methyl‐4‐Phenylpyridinium: Role of Glutathione

Journal of neurochemistry, 1996-08, Vol.67 (2), p.557-565

1996

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Neurochemical and behavioral effects of systemic and intranigral administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the rat

European journal of pharmacology, 1984-04, Vol.100 (2), p.189-194

1984

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3-Dimensional visualization of lesions in rat brain using magnetic resonance imaging microscopy

Neuroreport, 1999-03, Vol.10 (4), p.737-741

1999

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Selective retention of MPP + within the monoaminergic systems of the primate brain following MPTP administration: An in vivo autoradiographic study

Neuroscience, 1991, Vol.40 (1), p.133-158

1991

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MPTP treatment combined with ethanol or acetaldehyde selectively destroys dopaminergic neurons in mouse substantia nigra

Brain research, 1989-10, Vol.501 (1), p.1-10

1989

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Selective decrease in extracellular DOPAC concentrations in rat striatum following in vivo dialysis with low concentrations of MPP

Brain research, 1991-05, Vol.548 (1), p.94-99

1991

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Quantification of glutathione and glutathione disulfide in human plasma

Clinical chemistry (Baltimore, Md.), 1987-09, Vol.33 (9), p.1675-1676

1987

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1-methyl-4-phenylpyridine (MPP +) induces oxidative stress in the rodent

Life sciences (1973), 1986-02, Vol.38 (8), p.743-749

1986

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The neurochemical basis of footshock analgesia: the role of spinal cord serotonin and norepinephrine

Brain research, 1984-01, Vol.290 (1), p.107-117

1984

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Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the dog: effect of pargyline pretreatment

Journal of neurochemistry, 1989-08, Vol.53 (2), p.582-589

1989

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Prolonged alterations in canine striatal dopamine metabolism following subtoxic doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 4'-amino-MPTP are linked to the persistence of pyridinium metabolites

Journal of neurochemistry, 1991-09, Vol.57 (3), p.981-990

1991

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Differential uptake of HRP by intact axon terminals versus transected axons: A study on bulbospinal fibers in the dorsolateral funiculus

Neuroscience letters, 1990-07, Vol.114 (2), p.141-146

1990

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Non-serotonergic origins of the dorsolateral funiculus in the rat ventral medulla

The Journal of neuroscience, 1984-03, Vol.4 (3), p.757-766

1984

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Characterization of 1-methyl-4-[4′-amino]phenyl-1,2,3,6-tetrahydropyridine toxicity in the mouse

Biochemical pharmacology, 1990-08, Vol.40 (4), p.901-906

1990

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The Critical Path Initiative: Leveraging Collaborations to Enhance Regulatory Science

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

Stability of domoic acid in saline dosing solutions

3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys

Domoic acid: Neurobehavioral and neurohistological effects of low-dose exposure in adult rats

A model of chronic neurotoxicity : long-term retention of the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) within catecholaminergic neurons

Virtual Neuropathology: Three-Dimensional Visualization of Lesions Due to Toxic Insult

Neurohistochemical biomarkers of the marine neurotoxicant, domoic acid

Neurotoxic damage to the nigrostriatal system in rats following intranigral administration of MPDP+ and MPP

Saxitoxin Puffer Fish Poisoning in the United States, with the First Report of Pyrodinium bahamense as the Putative Toxin Source

Biomarkers used to assess the effect of dietary xylitol or sorbitol in the rat

Age‐Dependent Sensitivity of Cultured Peripheral Sympathetic Neurons to 1‐Methyl‐4‐Phenylpyridinium: Role of Glutathione

Neurochemical and behavioral effects of systemic and intranigral administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the rat

3-Dimensional visualization of lesions in rat brain using magnetic resonance imaging microscopy

Selective retention of MPP + within the monoaminergic systems of the primate brain following MPTP administration: An in vivo autoradiographic study

MPTP treatment combined with ethanol or acetaldehyde selectively destroys dopaminergic neurons in mouse substantia nigra

Selective decrease in extracellular DOPAC concentrations in rat striatum following in vivo dialysis with low concentrations of MPP

Quantification of glutathione and glutathione disulfide in human plasma

1-methyl-4-phenylpyridine (MPP +) induces oxidative stress in the rodent

The neurochemical basis of footshock analgesia: the role of spinal cord serotonin and norepinephrine

Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the dog: effect of pargyline pretreatment

Prolonged alterations in canine striatal dopamine metabolism following subtoxic doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 4'-amino-MPTP are linked to the persistence of pyridinium metabolites

Differential uptake of HRP by intact axon terminals versus transected axons: A study on bulbospinal fibers in the dorsolateral funiculus

Non-serotonergic origins of the dorsolateral funiculus in the rat ventral medulla

Characterization of 1-methyl-4-[4′-amino]phenyl-1,2,3,6-tetrahydropyridine toxicity in the mouse

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