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A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition

Nature communications, 2019-01, Vol.10 (1), p.96-14, Article 96

2019

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Nature (London), 2009-12, Vol.462 (7274), p.739-744

2009

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Nature (London), 2010-06, Vol.465 (7300), p.966-966

2010

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ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis

Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (29), p.9088-9093

2015

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Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency

Molecular therapy, 2016-07, Vol.24 (7), p.1187-1198

2016

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Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH

Cell reports (Cambridge), 2016-10, Vol.17 (3), p.876-890

2016

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A mouse model of a human congenital disorder of glycosylation caused by loss of PMM2

Human molecular genetics, 2016-06, Vol.25 (11), p.2182-2193

2016

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IDH mutations in glioma and acute myeloid leukemia

Trends in molecular medicine, 2010-09, Vol.16 (9), p.387-397

2010

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Ku70-Deficient Embryonic Stem Cells have Increased Ionizing Radiosensitivity, Defective DNA End-Binding Activity, and Inability to Support V(D)J Recombination

Proceedings of the National Academy of Sciences - PNAS, 1997-07, Vol.94 (15), p.8076-8081

1997

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Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae

Molecular and Cellular Biology, 1996-08, Vol.16 (8), p.4189-4198

1996

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Inactivation of DNA-Dependent Protein Kinase by Protein Kinase Cδ: Implications for Apoptosis

Molecular and Cellular Biology, 1998-11, Vol.18 (11), p.6719-6728

1998

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Functional interaction between DNA-PK and c-Abl in response to DNA damage

Nature (London), 1997-04, Vol.386 (6626), p.732-735

1997

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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

The Journal of experimental medicine, 2010-02, Vol.207 (2), p.339-344

2010

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Metabolic analysis reveals evidence for branched chain amino acid catabolism crosstalk and the potential for improved treatment of organic acidurias

Molecular genetics and metabolism, 2019-09, Vol.128 (1-2), p.57-61

2019

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The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development

Proceedings of the National Academy of Sciences - PNAS, 2016-12, Vol.113 (52), p.15084-15089

2016

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Nature chemical biology, 2012-10, Vol.8 (10), p.839

2012

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Binding of Ku and c-Abl at the Kinase Homology Region of DNA-dependent Protein Kinase Catalytic Subunit

The Journal of biological chemistry, 1997-10, Vol.272 (40), p.24763-24766

1997

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Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed : a phenotype partially reversed by selective estrogen receptor modulators

Cancer research (Chicago, Ill.), 2005-08, Vol.65 (15), p.6593-6600

2005

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Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2‑HG in Vivo

ACS medicinal chemistry letters, 2012-10, Vol.3 (10), p.850-855

2012

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Differential etoposide sensitivity of cells deficient in the Ku and DNA-PKcs components of the DNA-dependent protein kinase

Carcinogenesis (New York), 1998-06, Vol.19 (6), p.965-971

1998

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

Chemistry & biology, 2012-09, Vol.19 (9), p.1187-1198

2012

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Valosin-containing protein phosphorylation at Ser784 in response to DNA damage

Cancer research (Chicago, Ill.), 2005-09, Vol.65 (17), p.7533-7540

2005

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A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis

Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency

Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH

A mouse model of a human congenital disorder of glycosylation caused by loss of PMM2

IDH mutations in glioma and acute myeloid leukemia

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells

Ku70-Deficient Embryonic Stem Cells have Increased Ionizing Radiosensitivity, Defective DNA End-Binding Activity, and Inability to Support V(D)J Recombination

Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae

Inactivation of DNA-Dependent Protein Kinase by Protein Kinase Cδ: Implications for Apoptosis

Functional interaction between DNA-PK and c-Abl in response to DNA damage

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

Metabolic analysis reveals evidence for branched chain amino acid catabolism crosstalk and the potential for improved treatment of organic acidurias

The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Binding of Ku and c-Abl at the Kinase Homology Region of DNA-dependent Protein Kinase Catalytic Subunit

Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed : a phenotype partially reversed by selective estrogen receptor modulators

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2‑HG in Vivo

Differential etoposide sensitivity of cells deficient in the Ku and DNA-PKcs components of the DNA-dependent protein kinase

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

Valosin-containing protein phosphorylation at Ser784 in response to DNA damage

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