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Venoms as source of active peptides: An attractive approach to drug challenging targets at Sanofi

Toxicon (Oxford), 2016-06, Vol.116, p.78-78

2016

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New Modalities, Technologies, and Partnerships in Probe and Lead Generation: Enabling a Mode-of-Action Centric Paradigm

Journal of medicinal chemistry, 2018-10, Vol.61 (20), p.9004-9029

2018

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Synthesis, anticonvulsant and neuroprotective activities of RP 66055, a riluzole derivative

Bioorganic & medicinal chemistry, 1994, Vol.2 (8), p.793-798

1994

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RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis

The Journal of pharmacology and experimental therapeutics, 2001-10, Vol.299 (1), p.314

2001

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9-Carboxymethyl-5H, 10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one-2-carbocylic acid (RPR117824): Selective anticonvulsive and neuroprotective AMPA antagonist

Bioorganic & medicinal chemistry, 2002-05, Vol.10 (5), p.1627-1637

2002

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Indeno[1,2-b]pyrazin-2,3-diones: A New Class of Antagonists at the Glycine Site of the NMDA Receptor with Potent in Vivo Activity

Journal of medicinal chemistry, 2000-06, Vol.43 (12), p.2371-2381

2000

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Synthesis of C-2 substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines: binding studies on opioid receptors

European journal of medicinal chemistry, 1992-06, Vol.27 (4), p.369-381

1992

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4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity

Bioorganic & medicinal chemistry letters, 2000-05, Vol.10 (10), p.1133

2000

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Spiro-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one derivatives are mixed AMPA and NMDA glycine-site antagonists active in vivo

Bioorganic & medicinal chemistry letters, 1999-10, Vol.9 (20), p.2921-2926

1999

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Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2- a]indeno[1,2- e]pyrazin-8- and -9-carboxylic (acetic) acid AMPA antagonists

Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (24), p.2749-2754

2000

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Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action

Bioorganic & medicinal chemistry letters, 2001-01, Vol.11 (2), p.127-132

2001

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Synthesis of anticonvulsive AMPA antagonists: 4-Oxo-10-substituted-imidazo[1,2- a]indeno[1,2- e]pyrazin-2-carboxylic acid derivatives

Bioorganic & medicinal chemistry letters, 2001-05, Vol.11 (9), p.1205-1210

2001

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8-Methylureido-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno-[1,2-e]pyrazines : Highly potent in vivo AMPA antagonists

Bioorganic & medicinal chemistry letters, 2000-03, Vol.10 (6), p.591-596

2000

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Strategies for designing GPCR-focused libraries and screening sets

Current opinion in drug discovery & development, 2004-05, Vol.7 (3), p.325

2004

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8-methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e] pyrazine-4-ones : Highly in vivo potent and selective AMPA receptor antagonists

Bioorganic & medicinal chemistry, 2000-08, Vol.8 (8), p.2211-2217

2000

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Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz

Bioorganic & medicinal chemistry letters, 2001-05, Vol.11 (9), p.1205-1210

2001

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Synthesis and pharmacological properties of 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, a new competitive AMPA/KA receptor antagonist

Drug development research, 1999-11, Vol.48 (3), p.121-129

1999

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Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]inden

Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (24), p.2749

2000

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An Efficient Preparative Route to Fused Imidazo[1,2-a]pyrazin-4-one Derivatives

Heterocycles, 1999, Vol.50 (1), p.259

1999

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Neuroprotective effects of RPR 104632, a novel antagonist at the glycine site of the NMDA receptor, in vitro

European journal of pharmacology, 1996-04, Vol.300 (3), p.237-246

1996

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A Rapid Filtration Assay for the Glycine Binding Site on the NMDA Receptor in Rat Cortical Membranes using [3H]Dichlorokynurenic Acid

Journal of pharmacy and pharmacology, 1992-10, Vol.44 (10), p.812-816

1992

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1,2,4-thiadiazino [3,4-b] benzothiazole: a new cyclic sulphenimine

Heterocycles, 1993-12, Vol.36 (12), p.2745-2752

1993

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Synthesis and sar of 2h-1,2,4-benzothiadiazine-1,1-dioxide-3- carboxylic acid derivatives as novel potent glycine antagonists of the nmda receptor-channel complex

Bioorganic & medicinal chemistry letters, 1994, Vol.4 (23), p.2735-2740

1994

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2-Cyano Δ 3 Piperideines XIV: Facile synthesis of 1-substituted benzomorphans

Tetrahedron letters, 1987, Vol.28 (49), p.6179-6182

1987

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2-Cyano Δ3 Piperideines XIV: Facile synthesis of 1-substituted benzomorphans

Tetrahedron letters, 1987-01, Vol.28 (49), p.6179-6182

1987

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Venoms as source of active peptides: An attractive approach to drug challenging targets at Sanofi

New Modalities, Technologies, and Partnerships in Probe and Lead Generation: Enabling a Mode-of-Action Centric Paradigm

Synthesis, anticonvulsant and neuroprotective activities of RP 66055, a riluzole derivative

RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis

9-Carboxymethyl-5H, 10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one-2-carbocylic acid (RPR117824): Selective anticonvulsive and neuroprotective AMPA antagonist

Indeno[1,2-b]pyrazin-2,3-diones: A New Class of Antagonists at the Glycine Site of the NMDA Receptor with Potent in Vivo Activity

Synthesis of C-2 substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines: binding studies on opioid receptors

4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity

Spiro-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one derivatives are mixed AMPA and NMDA glycine-site antagonists active in vivo

Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2- a]indeno[1,2- e]pyrazin-8- and -9-carboxylic (acetic) acid AMPA antagonists

Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action

Synthesis of anticonvulsive AMPA antagonists: 4-Oxo-10-substituted-imidazo[1,2- a]indeno[1,2- e]pyrazin-2-carboxylic acid derivatives

8-Methylureido-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno-[1,2-e]pyrazines : Highly potent in vivo AMPA antagonists

Strategies for designing GPCR-focused libraries and screening sets

8-methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e] pyrazine-4-ones : Highly in vivo potent and selective AMPA receptor antagonists

Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz

Synthesis and pharmacological properties of 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, a new competitive AMPA/KA receptor antagonist

Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]inden

An Efficient Preparative Route to Fused Imidazo[1,2-a]pyrazin-4-one Derivatives

Neuroprotective effects of RPR 104632, a novel antagonist at the glycine site of the NMDA receptor, in vitro

A Rapid Filtration Assay for the Glycine Binding Site on the NMDA Receptor in Rat Cortical Membranes using [3H]Dichlorokynurenic Acid

1,2,4-thiadiazino [3,4-b] benzothiazole: a new cyclic sulphenimine

Synthesis and sar of 2h-1,2,4-benzothiadiazine-1,1-dioxide-3- carboxylic acid derivatives as novel potent glycine antagonists of the nmda receptor-channel complex

2-Cyano Δ 3 Piperideines XIV: Facile synthesis of 1-substituted benzomorphans

2-Cyano Δ3 Piperideines XIV: Facile synthesis of 1-substituted benzomorphans

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