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Super-enhancers and novel therapeutic targets in colorectal cancer

Cell death & disease, 2022-03, Vol.13 (3), p.228-10, Article 228

2022

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The inflammatory cytokine IL-6 induces FRA1 deacetylation promoting colorectal cancer stem-like properties

Oncogene, 2019-06, Vol.38 (25), p.4932-4947

2019

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A MYBL2 complex for RRM2 transactivation and the synthetic effect of MYBL2 knockdown with WEE1 inhibition against colorectal cancer

Cell death & disease, 2021-07, Vol.12 (7), p.683-11, Article 683

2021

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JMJD5 inhibits lung cancer progression by facilitating EGFR proteasomal degradation

Cell death & disease, 2023-10, Vol.14 (10), p.657-657, Article 657

2023

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IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial‐Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer

Stem cells (Dayton, Ohio), 2016-04, Vol.34 (4), p.820-831

2016

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Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial-mesenchymal transition

Carcinogenesis (New York), 2015-04, Vol.36 (4), p.459-468

2015

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Age‐related changes in metabolites in young donor livers and old recipient sera after liver transplantation from young to old rats

Aging cell, 2021-07, Vol.20 (7), p.e13425-n/a

2021

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Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein

Biochemical pharmacology, 2016-03, Vol.103, p.118-128

2016

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miR-377-3p-Mediated EGR1 Downregulation Promotes B[a]P-Induced Lung Tumorigenesis by Wnt/Beta-Catenin Transduction

Frontiers in oncology, 2021-08, Vol.11, p.699004-699004

2021

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Preclinical validation and phase I trial of 4-hydroxysalicylanilide, targeting ribonucleotide reductase mediated dNTP synthesis in multiple myeloma

Journal of biomedical science, 2022-05, Vol.29 (1), p.32-32, Article 32

2022

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Cancer-derived immunoglobulin G promotes LPS-induced proinflammatory cytokine production via binding to TLR4 in cervical cancer cells

Oncotarget, 2014-10, Vol.5 (20), p.9727-9743

2014

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Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase

Biochemistry (Easton), 2017-02, Vol.56 (6), p.856-868

2017

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ATR–CHK1–E2F3 signaling transactivates human ribonucleotide reductase small subunit M2 for DNA repair induced by the chemical carcinogen MNNG

Biochimica et biophysica acta, 2016-04, Vol.1859 (4), p.612-626

2016

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Identification and functional implication of nuclear localization signals in the N-terminal domain of JMJD5

Biochimie, 2013-11, Vol.95 (11), p.2114-2122

2013

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STAT3 activates MSK1-mediated histone H3 phosphorylation to promote NFAT signaling in gastric carcinogenesis

Oncogenesis (New York, NY), 2020-02, Vol.9 (2), p.15, Article 15

2020

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A Ferrous-triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase

Molecular cancer therapeutics, 2006-03, Vol.5 (3), p.586-592

2006

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Identification of Monobenzone as a Novel Potential Anti-Acute Myeloid Leukaemia Agent That Inhibits RNR and Suppresses Tumour Growth in Mouse Xenograft Model

Cancers, 2022-09, Vol.14 (19), p.4710

2022

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Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers

Frontiers in oncology, 2019-10, Vol.9, p.956-956

2019

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CREB1 directly activates the transcription of ribonucleotide reductase small subunit M2 and promotes the aggressiveness of human colorectal cancer

Oncotarget, 2016-11, Vol.7 (47), p.78055-78068

2016

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Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase

Biochemical pharmacology, 2009-11, Vol.78 (9), p.1178-1185

2009

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Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target

Cancer communications (London, England), 2022-02, Vol.42 (2), p.164-169

2022

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Abstract 1997: Pro-inflammatory cytokine IL-6 induces the upregulation and deacetylation of FRA-1, thus promoting colon cancer stemness and aggressiveness

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1997-1997

2018

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Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis

Carcinogenesis (New York), 2018-12, Vol.39 (11), p.1368-1379

2018

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Early whole-genome transcriptional response induced by benzo[a]pyrene diol epoxide in a normal human cell line

Genomics (San Diego, Calif.), 2009-04, Vol.93 (4), p.332-342

2009

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In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase

Cancer research (Chicago, Ill.), 2004, Vol.64 (1), p.1-6

2004

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Super-enhancers and novel therapeutic targets in colorectal cancer

The inflammatory cytokine IL-6 induces FRA1 deacetylation promoting colorectal cancer stem-like properties

A MYBL2 complex for RRM2 transactivation and the synthetic effect of MYBL2 knockdown with WEE1 inhibition against colorectal cancer

JMJD5 inhibits lung cancer progression by facilitating EGFR proteasomal degradation

IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial‐Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer

Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial-mesenchymal transition

Age‐related changes in metabolites in young donor livers and old recipient sera after liver transplantation from young to old rats

Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein

miR-377-3p-Mediated EGR1 Downregulation Promotes B[a]P-Induced Lung Tumorigenesis by Wnt/Beta-Catenin Transduction

Preclinical validation and phase I trial of 4-hydroxysalicylanilide, targeting ribonucleotide reductase mediated dNTP synthesis in multiple myeloma

Cancer-derived immunoglobulin G promotes LPS-induced proinflammatory cytokine production via binding to TLR4 in cervical cancer cells

Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase

ATR–CHK1–E2F3 signaling transactivates human ribonucleotide reductase small subunit M2 for DNA repair induced by the chemical carcinogen MNNG

Identification and functional implication of nuclear localization signals in the N-terminal domain of JMJD5

STAT3 activates MSK1-mediated histone H3 phosphorylation to promote NFAT signaling in gastric carcinogenesis

A Ferrous-triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase

Identification of Monobenzone as a Novel Potential Anti-Acute Myeloid Leukaemia Agent That Inhibits RNR and Suppresses Tumour Growth in Mouse Xenograft Model

Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers

CREB1 directly activates the transcription of ribonucleotide reductase small subunit M2 and promotes the aggressiveness of human colorectal cancer

Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase

Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target

Abstract 1997: Pro-inflammatory cytokine IL-6 induces the upregulation and deacetylation of FRA-1, thus promoting colon cancer stemness and aggressiveness

Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis

Early whole-genome transcriptional response induced by benzo[a]pyrene diol epoxide in a normal human cell line

In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase

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