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Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors

Cancer research (Chicago, Ill.), 2008-10, Vol.68 (20), p.8322-8332

2008

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Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor

Future medicinal chemistry, 2009-09, Vol.1 (6), p.1153-1171

2009

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A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor–dependent tumor growth in vivo

Molecular cancer therapeutics, 2007-08, Vol.6 (8), p.2158-2167

2007

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Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

The EMBO journal, 2008-07, Vol.27 (14), p.1985-1994

2008

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Focal adhesion kinase promotes phospholipase C-γ1 activity

Proceedings of the National Academy of Sciences - PNAS, 1999-08, Vol.96 (16), p.9021-9026

1999

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Essential role of the tyrosine kinase substrate phospholipase C-γ1 in mammalian growth and development

Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (7), p.2999-3003

1997

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Phospholipase C-γ as a Signal-Transducing Element

Experimental cell research, 1999-11, Vol.253 (1), p.15-24

1999

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Physiological Requirement for Both SH2 Domains for Phospholipase C-γ1 Function and Interaction with Platelet-Derived Growth Factor Receptors

Molecular and Cellular Biology, 1999-07, Vol.19 (7), p.4961-4970

1999

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The Role of Individual SH2 Domains in Mediating Association of Phospholipase C-γ1 with the Activated EGF Receptor

The Journal of biological chemistry, 1999-09, Vol.274 (37), p.26091-26097

1999

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Novel 2-phenylquinolin-7-yl-derived imidazo[1,5- a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors

Bioorganic & medicinal chemistry, 2008-02, Vol.16 (3), p.1359-1375

2008

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Role of basal calcium in the EGF activation of MAP kinases

Oncogene, 2000-03, Vol.19 (14), p.1853-1856

2000

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Phospholipase C-γ1 is required for cell survival in oxidative stress by protein kinase C

Biochemical journal, 2002-04, Vol.363 (2), p.395

2002

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1,3-Disubstituted-imidazo[1,5- a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.1091-1097

2007

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Inhibition of the IGF-I receptor for treatment of cancer. Kinase inhibitors and monoclonal antibodies as alternative approaches

Recent results in cancer research, 2007, Vol.172, p.59

2007

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Phospholipase C-γ1 Is Required for the Induction of Immediate Early Genes by Platelet-derived Growth Factor

The Journal of biological chemistry, 2001-03, Vol.276 (12), p.8627-8630

2001

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Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts

Molecular biology of the cell, 1998-04, Vol.9 (4), p.749-757

1998

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Analysis of Platelet-derived Growth Factor-induced Phospholipase D Activation in Mouse Embryo Fibroblasts Lacking Phospholipase C-γ1

The Journal of biological chemistry, 1998-08, Vol.273 (32), p.20517-20524

1998

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Identification of VEGFR3 gene mutation in a Chinese family with autosomal dominant primary congenital lymphoedema

Zhonghua yi xue yi chuan xue za zhi, 2010-08, Vol.27 (4), p.371

2010

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Phospholipase C-γ1 is required for cell survival in oxidative stress by protein kinase C

Biochemical journal, 2002-04, Vol.363 (2), p.395-401

2002

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Essential Role of the Tyrosine Kinase Substrate Phospholipase C-γ 1 in Mammalian Growth and Development

Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (7), p.2999-3003

1997

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Phospholipase C-gamma1 is required for survival in heat stress: involvement of protein kinase C-dependent Bcl-2 phosphorylation

Journal of biochemistry (Tokyo), 2002-02, Vol.131 (2), p.207-212

2002

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Phospholipase C-Î³1 Is Required for the Induction of Immediate Early Genes by Platelet-derived Growth Factor

The Journal of biological chemistry, 2001-03, Vol.276 (12), p.8627

2001

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Phospholipase C-γI Is Required for Survival in Heat Stress: Involvement of Protein Kinase C-Depertment Bel-2 Phosphorylation

Journal of biochemistry (Tokyo), 2002-02, Vol.131 (2), p.207-212

2002

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The Role of Individual SH2 Domains in Mediating Association of Phospholipase C-Î³1 with the Activated EGF Receptor

The Journal of biological chemistry, 1999-09, Vol.274 (37), p.26091

1999

Volltextzugriff (PDF)

Analysis of Platelet-derived Growth Factor-induced Phospholipase D Activation in Mouse Embryo Fibroblasts Lacking Phospholipase C-Î³1

The Journal of biological chemistry, 1998-08, Vol.273 (32), p.20517

1998

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Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor

A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor–dependent tumor growth in vivo

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

Focal adhesion kinase promotes phospholipase C-γ1 activity

Essential role of the tyrosine kinase substrate phospholipase C-γ1 in mammalian growth and development

Phospholipase C-γ as a Signal-Transducing Element

Physiological Requirement for Both SH2 Domains for Phospholipase C-γ1 Function and Interaction with Platelet-Derived Growth Factor Receptors

The Role of Individual SH2 Domains in Mediating Association of Phospholipase C-γ1 with the Activated EGF Receptor

Novel 2-phenylquinolin-7-yl-derived imidazo[1,5- a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors

Role of basal calcium in the EGF activation of MAP kinases

Phospholipase C-γ1 is required for cell survival in oxidative stress by protein kinase C

1,3-Disubstituted-imidazo[1,5- a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors

Inhibition of the IGF-I receptor for treatment of cancer. Kinase inhibitors and monoclonal antibodies as alternative approaches

Phospholipase C-γ1 Is Required for the Induction of Immediate Early Genes by Platelet-derived Growth Factor

Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts

Analysis of Platelet-derived Growth Factor-induced Phospholipase D Activation in Mouse Embryo Fibroblasts Lacking Phospholipase C-γ1

Identification of VEGFR3 gene mutation in a Chinese family with autosomal dominant primary congenital lymphoedema

Phospholipase C-γ1 is required for cell survival in oxidative stress by protein kinase C

Essential Role of the Tyrosine Kinase Substrate Phospholipase C-γ 1 in Mammalian Growth and Development

Phospholipase C-gamma1 is required for survival in heat stress: involvement of protein kinase C-dependent Bcl-2 phosphorylation

Phospholipase C-Î³1 Is Required for the Induction of Immediate Early Genes by Platelet-derived Growth Factor

Phospholipase C-γI Is Required for Survival in Heat Stress: Involvement of Protein Kinase C-Depertment Bel-2 Phosphorylation

The Role of Individual SH2 Domains in Mediating Association of Phospholipase C-Î³1 with the Activated EGF Receptor

Analysis of Platelet-derived Growth Factor-induced Phospholipase D Activation in Mouse Embryo Fibroblasts Lacking Phospholipase C-Î³1

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