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Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi)

Journal of clinical pharmacology, 2010-04, Vol.50 (4), p.401-414

2010

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The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors

Current medicinal chemistry, 2004-11, Vol.11 (22), p.2911-2977

2004

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Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects

Journal of translational medicine, 2014-12, Vol.12 (1), p.340-340, Article 340

2014

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Structure–Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors

Journal of medicinal chemistry, 2015-06, Vol.58 (11), p.4749-4770

2015

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Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats

American journal of physiology. Regulatory, integrative and comparative physiology, 2009-04, Vol.296 (4), p.R994-R1000

2009

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Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage

Circulation (New York, N.Y.), 2005-06, Vol.111 (23), p.3087-3094

2005

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FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice

Journal of hypertension, 2010-09, Vol.28 (9), p.1900-1907

2010

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Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na+ in Wistar rats

American journal of physiology. Regulatory, integrative and comparative physiology, 2008-07, Vol.295 (1), p.R166-R172

2008

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Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors

Analytical biochemistry, 2009-11, Vol.394 (1), p.56-61

2009

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Dual ECE/NEP Inhibition on Cardiac and Neurohumoral Function During the Transition From Hypertrophy to Heart Failure in Rats

Hypertension (Dallas, Tex. 1979), 2005-06, Vol.45 (6), p.1145-1152

2005

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Attenuation of experimental subarachnoid hemorrhage-induced increases in circulating intercellular adhesion molecule-1 and cerebral vasospasm by the endothelin-converting enzyme inhibitor CGS 26303

Journal of neurosurgery, 2007-03, Vol.106 (3), p.442-448

2007

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Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone

European heart journal, 2008-09, Vol.29 (17), p.2171-2179

2008

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Towards Triple Vasopeptidase Inhibitors for the Treatment of Cardiovascular Diseases

Journal of cardiovascular pharmacology, 2007-09, Vol.50 (3), p.247-256

2007

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Discovery of N‑[5-(6-Chloro-3-cyano-1-methyl‑1H‑indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects

Journal of medicinal chemistry, 2015-12, Vol.58 (23), p.9382-9394

2015

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FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice

Journal of hypertension, 2010-09, p.1

2010

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The design, structure, and therapeutic application of matrix metalloproteinase inhibitors

Current medicinal chemistry, 2001-03, Vol.8 (4), p.425-474

2001

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Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors

ACS medicinal chemistry letters, 2020-02, Vol.11 (2), p.188-194

2020

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Isoindolines: A new series of potent and selective endothelin-A receptor antagonists

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (13), p.1737-1740

2001

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Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

ACS medicinal chemistry letters, 2013-12, Vol.4 (12), p.1203-1207

2013

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Upregulation of endothelial nitric oxide synthase and endothelin-1 in pulmonary hypertension secondary to heart failure in aorta-banded rats

Pediatric pulmonology, 2004-03, Vol.37 (3), p.249-256

2004

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Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction

Cardiovascular research, 2009-02, Vol.81 (3), p.574-581

2009

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CGS 34226, a thiol-based dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11

Clinical science (1979), 2002-08, Vol.103 Suppl 48 (s2002), p.98S-101S

2002

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Design and Synthesis of Potent, Selective Inhibitors of Endothelin-Converting Enzyme

Journal of medicinal chemistry, 1998-04, Vol.41 (9), p.1513-1523

1998

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Effects of increased pulmonary flow on the expression of endothelial nitric oxide synthase and endothelin-1 in the rat

Clinical science (1979), 2002-08, Vol.103 Suppl 48 (s2002), p.289S-293S

2002

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The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-β-hydroxylase

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (15), p.4324-4327

2010

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Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi)

The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors

Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects

Structure–Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors

Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats

Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage

FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice

Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na+ in Wistar rats

Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors

Dual ECE/NEP Inhibition on Cardiac and Neurohumoral Function During the Transition From Hypertrophy to Heart Failure in Rats

Attenuation of experimental subarachnoid hemorrhage-induced increases in circulating intercellular adhesion molecule-1 and cerebral vasospasm by the endothelin-converting enzyme inhibitor CGS 26303

Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone

Towards Triple Vasopeptidase Inhibitors for the Treatment of Cardiovascular Diseases

Discovery of N‑[5-(6-Chloro-3-cyano-1-methyl‑1H‑indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects

FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice

The design, structure, and therapeutic application of matrix metalloproteinase inhibitors

Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors

Isoindolines: A new series of potent and selective endothelin-A receptor antagonists

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

Upregulation of endothelial nitric oxide synthase and endothelin-1 in pulmonary hypertension secondary to heart failure in aorta-banded rats

Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction

CGS 34226, a thiol-based dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11

Design and Synthesis of Potent, Selective Inhibitors of Endothelin-Converting Enzyme

Effects of increased pulmonary flow on the expression of endothelial nitric oxide synthase and endothelin-1 in the rat

The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-β-hydroxylase

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