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JNJ-26481585, a Novel “Second-Generation” Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity

Clinical cancer research, 2009-11, Vol.15 (22), p.6841-6851

2009

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Safety evaluation of long-term temperature controlled whole-body thermal treatment in female Aachen minipig

International journal of hyperthermia, 2021-01, Vol.38 (1), p.165-175

2021

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Biological Role and Therapeutic Targeting of TGF-β3 in Glioblastoma

Molecular cancer therapeutics, 2017-06, Vol.16 (6), p.1177-1186

2017

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Disruption of Murine Mus81 Increases Genomic Instability and DNA Damage Sensitivity but Does Not Promote Tumorigenesis

Molecular and Cellular Biology, 2005-09, Vol.25 (17), p.7569-7579

2005

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Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth

Molecular biology of the cell, 2005-12, Vol.16 (12), p.5621-5629

2005

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Transcriptome-wide analysis reveals insight into tumor suppressor functions of 1B3, a novel synthetic miR-193a-3p mimic

Molecular therapy. Nucleic acids, 2021-03, Vol.23, p.1161-1171

2021

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The tumor suppressor 5A2, a synthetic miR-7-5p mimic, targets oncogenic and metabolic pathways, as revealed by transcriptome-wide analysis

Frontiers in drug discovery, 2023-07, Vol.3

2023

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Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles

Cancer biology & therapy, 2004-07, Vol.3 (7), p.641-650

2004

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Therapeutic Targeting of TGFβ Ligands in Glioblastoma Using Novel Antisense Oligonucleotides Reduces the Growth of Experimental Gliomas

Clinical cancer research, 2019-12, Vol.25 (23), p.7189-7201

2019

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Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin

The Journal of pharmacology and experimental therapeutics, 2003-02, Vol.304 (2), p.881-888

2003

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Design and Selection of Antisense Oligonucleotides Targeting Transforming Growth Factor Beta (TGF-β) Isoform mRNAs for the Treatment of Solid Tumors

Methods in molecular biology (Clifton, N.J.), 2015, Vol.1317, p.137

2015

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Hyperthermia enhances the effects of chemotherapeutic agents on pancreatic cancer cell proliferation and survival

European journal of surgical oncology, 2022-02, Vol.48 (2), p.e173-e173

2022

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Phase I/Ib study with INT-1B3, a novel LNP-formulated micro-RNA (miR-193a-3p mimic) therapeutic for patients with advanced solid cancer

Journal of clinical oncology, 2021-05, Vol.39 (15_suppl), p.TPS2666-TPS2666

2021

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EXTH-35. THERAPEUTIC TARGETING OF TGF-β1/2 IN GLIOBLASTOMA USING NOVEL ANTISENSE OLIGONUCLEOTIDES

Neuro-oncology (Charlottesville, Va.), 2016-11, Vol.18 (suppl_6), p.vi67-vi67

2016

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Biological Role and Therapeutic Targeting of TGF-β 3 in Glioblastoma

Molecular cancer therapeutics, 2017-06, Vol.16 (6), p.1177-1186

2017

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Abstract 717: Novel potent antisense oligonucleotides targeting transforming growth factor beta1 (TGF-β1)

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.717-717

2014

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Safety and preliminary efficacy of long-term whole-body thermal treatment in advanced cancer-bearing dogs

European journal of surgical oncology, 2022-02, Vol.48 (2), p.e139-e139

2022

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The Wnt-dependent signaling pathways as target in oncology drug discovery

Investigational new drugs, 2006-07, Vol.24 (4), p.263-280

2006

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TGF-β1 and TGF-β2 abundance in liver diseases of mice and men

Oncotarget, 2016-04, Vol.7 (15), p.19499-19518

2016

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Abstract 4405: Pharmacologic profile of INT-1B3: A novel synthetic microRNA 193a-3p mimic for therapeutic intervention in oncology

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4405-4405

2018

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First-in-human phase I study of ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), in subjects with open-angle glaucoma undergoing glaucoma filtration surgery

JNJ-26481585, a Novel “Second-Generation” Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity

Safety evaluation of long-term temperature controlled whole-body thermal treatment in female Aachen minipig

Biological Role and Therapeutic Targeting of TGF-β3 in Glioblastoma

Disruption of Murine Mus81 Increases Genomic Instability and DNA Damage Sensitivity but Does Not Promote Tumorigenesis

Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth

Transcriptome-wide analysis reveals insight into tumor suppressor functions of 1B3, a novel synthetic miR-193a-3p mimic

The tumor suppressor 5A2, a synthetic miR-7-5p mimic, targets oncogenic and metabolic pathways, as revealed by transcriptome-wide analysis

P422: TARGETING THE WT1MUT‐MIR‐193A TRANSCRIPTIONAL AXIS WITH INT‐1B3, A NOVEL LIPID NANOPARTICLE‐FORMULATED MIR‐193A‐3P MIMIC IN ACUTE MYELOID LEUKEMIA

Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles

Therapeutic Targeting of TGFβ Ligands in Glioblastoma Using Novel Antisense Oligonucleotides Reduces the Growth of Experimental Gliomas

Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin

Design and Selection of Antisense Oligonucleotides Targeting Transforming Growth Factor Beta (TGF-β) Isoform mRNAs for the Treatment of Solid Tumors

TGF-β2 silencing to target biliary-derived liver diseases

Hyperthermia enhances the effects of chemotherapeutic agents on pancreatic cancer cell proliferation and survival

Phase I/Ib study with INT-1B3, a novel LNP-formulated micro-RNA (miR-193a-3p mimic) therapeutic for patients with advanced solid cancer

Targeting the WT1mut-Mir-193a Transcriptional Axis with INT-1B3, a Novel Lipid Nanoparticle-Formulated Mir-193a-3p Mimic in Acute Myeloid Leukemia

Targeting the WT1mut -M ir-193a Transcriptional Axis with INT-1B3, a Novel Lipid Nanoparticle-Formulated Mir -193a-3p Mimic in Acute Myeloid Leukemia

EXTH-35. THERAPEUTIC TARGETING OF TGF-β1/2 IN GLIOBLASTOMA USING NOVEL ANTISENSE OLIGONUCLEOTIDES

Biological Role and Therapeutic Targeting of TGF-β 3 in Glioblastoma

Abstract 717: Novel potent antisense oligonucleotides targeting transforming growth factor beta1 (TGF-β1)

Safety and preliminary efficacy of long-term whole-body thermal treatment in advanced cancer-bearing dogs

The Wnt-dependent signaling pathways as target in oncology drug discovery

TGF-β1 and TGF-β2 abundance in liver diseases of mice and men

Abstract 4405: Pharmacologic profile of INT-1B3: A novel synthetic microRNA 193a-3p mimic for therapeutic intervention in oncology

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