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From XenoMouse technology to panitumumab, the first fully human antibody product from transgenic mice

Nature biotechnology, 2007-10, Vol.25 (10), p.1134-1143

2007

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Monoclonal antibodies to six-transmembrane epithelial antigen of the prostate-1 inhibit intercellular communication In vitro and growth of human tumor xenografts In vivo

Cancer research (Chicago, Ill.), 2007-06, Vol.67 (12), p.5798-5805

2007

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Anti-PSCA mAbs Inhibit Tumor Growth and Metastasis Formation and Prolong the Survival of Mice Bearing Human Prostate Cancer Xenografts

Proceedings of the National Academy of Sciences - PNAS, 2001-02, Vol.98 (5), p.2658-2663

2001

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STEAP: A Prostate-Specific Cell-Surface Antigen Highly Expressed in Human Prostate Tumors

Proceedings of the National Academy of Sciences - PNAS, 1999-12, Vol.96 (25), p.14523-14528

1999

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Production of fully human antibodies by transgenic mice

Current opinion in biotechnology, 1995, Vol.6 (5), p.561-566

Jakobovits, Aya

1995

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Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy

Cancer research (Chicago, Ill.), 1999-03, Vol.59 (6), p.1236-1243

1999

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Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia

Cancer research (Chicago, Ill.), 2001-02, Vol.61 (4), p.1686-1692

2001

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Production and selection of antigen-specific fully human monoclonal antibodies from mice engineered with human Ig loci

Advanced drug delivery reviews, 1998-04, Vol.31 (1), p.33-42

Jakobovits, Aya

1998

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Abstract 2436: AGS-16M8F is a novel antibody drug conjugate (ADC) for treating renal and liver cancers

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.2436-2436

2010

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Abstract 4393: ASG-5ME is a novel antibody drug conjugate (ADC) for treating prostate cancers

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.4393-4393

2010

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Abstract 2590: Preclinical evaluation of ASG-5ME, a novel antibody-drug conjugate for pancreatic cancer

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.2590-2590

2010

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Tools of the Trade YAC Vectors: Humanizing the mouse genome

Current biology, 1994-08, Vol.4 (8), p.761-763

Jakobovits, Aya

1994

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The long-awaited magic bullets: therapeutic human monoclonal antibodies from transgenic mice

Expert opinion on investigational drugs, 1998-04, Vol.7 (4), p.607-614

Jakobovits, Aya

1998

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Inactivation of the MouseHPRTLocus by a 203-bp Retroposon Insertion and a 55-kb Gene-Targeted Deletion: Establishment of New HPRT-Deficient Mouse Embryonic Stem Cell Lines

Genomics (San Diego, Calif.), 1997-06, Vol.42 (3), p.413-421

1997

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Regulation of B cell development by variable gene complexity in mice reconstituted with human immunoglobulin yeast artificial chromosomes

The Journal of experimental medicine, 1998-08, Vol.188 (3), p.483-495

1998

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The human immunoglobulin loci introduced into mice: V (D) and J gene segment usage similar to that of adult humans

European journal of immunology, 2000-02, Vol.30 (2), p.534-540

2000

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AGS-PSCA: A FULLY HUMAN ANTIBODY TO PSCA FOR THE TREATMENT OF PANCREATIC CANCER

Pancreas, 2005-11, Vol.31 (4), p.448

2005

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Germ-line transmission and expression of a human-derived yeast artificial chromosome

Nature (London), 1993-03, Vol.362 (6417), p.255-258

1993

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Trans‐activation of HIV‐1 LTR‐directed gene expression by tat requires protein kinase C

The EMBO journal, 1990-04, Vol.9 (4), p.1165-1170

1990

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Target antigens for prostate cancer immunotherapy

Cancer and metastasis reviews, 1999, Vol.18 (4), p.437-449

1999

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Analysis of Homozygous Mutant Chimeric Mice: Deletion of the Immunoglobulin Heavy-Chain Joining Region Blocks B-Cell Development and Antibody Production

Proceedings of the National Academy of Sciences - PNAS, 1993-03, Vol.90 (6), p.2551-2555

1993

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Two Proto-Oncogenes Implicated in Mammary Carcinogenesis, int-1 and int-2, are Independently Regulated during Mouse Development

Proceedings of the National Academy of Sciences - PNAS, 1986-10, Vol.83 (20), p.7806-7810

1986

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Inactivation of the mouse HPRT locus by a 203-bp retroposon insertion and a 55-kb gene-targeted deletion : Establishment of new HPRT-deficient mouse embryonic stem cell lines

Genomics (San Diego, Calif.), 1997-06, Vol.42 (3), p.413-421

1997

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Expression of N- myc in teratocarcinoma stem cells and mouse embryos

Nature (London), 1985-01, Vol.318 (6042), p.188-191

1985

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Production of Antigen-Specific Human Antibodies from Mice Engineered with Human Heavy and Light Chain YACs

Annals of the New York Academy of Sciences, 1995-09, Vol.764 (1), p.525-535

1995

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From XenoMouse technology to panitumumab, the first fully human antibody product from transgenic mice

Monoclonal antibodies to six-transmembrane epithelial antigen of the prostate-1 inhibit intercellular communication In vitro and growth of human tumor xenografts In vivo

Anti-PSCA mAbs Inhibit Tumor Growth and Metastasis Formation and Prolong the Survival of Mice Bearing Human Prostate Cancer Xenografts

STEAP: A Prostate-Specific Cell-Surface Antigen Highly Expressed in Human Prostate Tumors

Production of fully human antibodies by transgenic mice

Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy

Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia

Production and selection of antigen-specific fully human monoclonal antibodies from mice engineered with human Ig loci

Abstract 2436: AGS-16M8F is a novel antibody drug conjugate (ADC) for treating renal and liver cancers

Abstract 4393: ASG-5ME is a novel antibody drug conjugate (ADC) for treating prostate cancers

Abstract 2590: Preclinical evaluation of ASG-5ME, a novel antibody-drug conjugate for pancreatic cancer

Tools of the Trade YAC Vectors: Humanizing the mouse genome

The long-awaited magic bullets: therapeutic human monoclonal antibodies from transgenic mice

Inactivation of the MouseHPRTLocus by a 203-bp Retroposon Insertion and a 55-kb Gene-Targeted Deletion: Establishment of New HPRT-Deficient Mouse Embryonic Stem Cell Lines

Regulation of B cell development by variable gene complexity in mice reconstituted with human immunoglobulin yeast artificial chromosomes

The human immunoglobulin loci introduced into mice: V (D) and J gene segment usage similar to that of adult humans

AGS-PSCA: A FULLY HUMAN ANTIBODY TO PSCA FOR THE TREATMENT OF PANCREATIC CANCER

Germ-line transmission and expression of a human-derived yeast artificial chromosome

Trans‐activation of HIV‐1 LTR‐directed gene expression by tat requires protein kinase C

Target antigens for prostate cancer immunotherapy

Analysis of Homozygous Mutant Chimeric Mice: Deletion of the Immunoglobulin Heavy-Chain Joining Region Blocks B-Cell Development and Antibody Production

Two Proto-Oncogenes Implicated in Mammary Carcinogenesis, int-1 and int-2, are Independently Regulated during Mouse Development

Inactivation of the mouse HPRT locus by a 203-bp retroposon insertion and a 55-kb gene-targeted deletion : Establishment of new HPRT-deficient mouse embryonic stem cell lines

Expression of N- myc in teratocarcinoma stem cells and mouse embryos

Production of Antigen-Specific Human Antibodies from Mice Engineered with Human Heavy and Light Chain YACs

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