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Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

Journal of medicinal chemistry, 1991-01, Vol.34 (1), p.98-107

1991

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Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

Journal of medicinal chemistry, 1989-03, Vol.32 (3), p.715-720

1989

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Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists

Journal of medicinal chemistry, 1999-02, Vol.42 (4), p.545-559

1999

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Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists

Journal of medicinal chemistry, 1996-12, Vol.39 (25), p.4867-4870

1996

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Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonists

Bioorganic & medicinal chemistry letters, 1998-11, Vol.8 (22), p.3165-3170

1998

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Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonist with efficacy in a restenosis model

Bioorganic & medicinal chemistry letters, 1998-11, Vol.8 (22), p.3171-3176

1998

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In vitro and in vivo pharmacological characterization of SB 201993, an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity

Prostaglandins, leukotrienes and essential fatty acids, 1999-07, Vol.61 (1), p.55-64

1999

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Preclinical pharmacokinetics and interspecies scaling of a novel vitronectin receptor antagonist

Drug metabolism and disposition, 1999-11, Vol.27 (11), p.1232

1999

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Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model

Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (13), p.1807-1812

1999

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Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK

Journal of medicinal chemistry, 2003-04, Vol.46 (9), p.1627-1635

2003

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Antimicrobial activity of SK&F 88070, an expanded-spectrum cephalosporin with high and prolonged levels in blood

Antimicrobial Agents and Chemotherapy, 1984-06, Vol.25 (6), p.694-700

1984

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Defining and Combating the Mechanisms of Triclosan Resistance in Clinical Isolates of Staphylococcus aureus

Antimicrobial Agents and Chemotherapy, 2002-11, Vol.46 (11), p.3343-3347

2002

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Determination of leucine aminopeptidase using phenylalanyl-3-thia-phenylalanine as substrate

Analytical biochemistry, 1986-05, Vol.154 (2), p.552-558

1986

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(E)-3-[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic acid: a novel high-affinity leukotriene B4 receptor antagonist

Journal of medicinal chemistry, 1993-09, Vol.36 (18), p.2703-2705

1993

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Trisubstituted pyridine leukotriene B4 receptor antagonists: synthesis and structure-activity relationships

Journal of medicinal chemistry, 1993-10, Vol.36 (22), p.3321-3332

1993

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Semisynthetic cephalosporins. Synthesis and structure-activity relationships of 7-mandelamido-3-cephem-4-carboxylic acids

Journal of medicinal chemistry, 1974-01, Vol.17 (1), p.34-41

1974

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ORALLY ACTIVE 7-PHENYLGLYCYL CEPHALOSPORINS: STRUCTURE-ACTIVITY STUDIES RELATED TO CEFATRIZINE (SK&F 60771)

The Journal of Antibiotics, 1976, Vol.29(1), pp.65-80

1976

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Semisynthetic cephalosporins. Synthesis and structure-activity relations of 7-mandelamido-3-cephem-4-carboxylic acids

Journal of medicinal chemistry, 1974-01, Vol.17 (1), p.34-41

1974

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Direct design of a potent non-peptide fibrinogen receptor antagonist based on the structure and conformation of a highly constrained cyclic RGD peptide

Journal of the American Chemical Society, 1993-09, Vol.115 (19), p.8861-8862

1993

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(E)-3-[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic Acid and Related Compounds: High Affinity Leukotriene B4 Receptor Antagonists

Journal of medicinal chemistry, 1994-09, Vol.37 (20), p.3327-3336

1994

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Preparation of some trimethylpentacyclo-[5.4.0.02,6.03,10.05,9]undecane-8,11-dione derivatives

Journal of medicinal chemistry, 1971-12, Vol.14 (12), p.1242-1243

1971

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The use of rabbit intestinal permeability as an in vitro assay in the search for orally active GPIIb/IIIa antagonists: In vitro models for selection of development candidates

Advanced drug delivery reviews, 1997, Vol.23 (1-3), p.133-142

1997

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Preparation of 1-substituted bicyclo[3.2.1]octanes by a rearrangement reaction

Tetrahedron letters, 1966, Vol.7 (44), p.5427-5431

1966

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The use of rabbit intestinal permeability as an in vitro assay in the search for orally active GPIIb/IIIa antagonists

Advanced drug delivery reviews, 1997-01, Vol.23 (1), p.133-142

1997

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(E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]benzoic acid and related compounds : high affinity leukotriene B4 receptor antagonists

Journal of medicinal chemistry, 1994, Vol.37 (20), p.3327-3336

1994

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Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists

Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists

Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonists

Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonist with efficacy in a restenosis model

In vitro and in vivo pharmacological characterization of SB 201993, an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity

Preclinical pharmacokinetics and interspecies scaling of a novel vitronectin receptor antagonist

Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model

Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK

Antimicrobial activity of SK&F 88070, an expanded-spectrum cephalosporin with high and prolonged levels in blood

Defining and Combating the Mechanisms of Triclosan Resistance in Clinical Isolates of Staphylococcus aureus

Determination of leucine aminopeptidase using phenylalanyl-3-thia-phenylalanine as substrate

(E)-3-[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic acid: a novel high-affinity leukotriene B4 receptor antagonist

Trisubstituted pyridine leukotriene B4 receptor antagonists: synthesis and structure-activity relationships

Semisynthetic cephalosporins. Synthesis and structure-activity relationships of 7-mandelamido-3-cephem-4-carboxylic acids

ORALLY ACTIVE 7-PHENYLGLYCYL CEPHALOSPORINS: STRUCTURE-ACTIVITY STUDIES RELATED TO CEFATRIZINE (SK&F 60771)

Semisynthetic cephalosporins. Synthesis and structure-activity relations of 7-mandelamido-3-cephem-4-carboxylic acids

Direct design of a potent non-peptide fibrinogen receptor antagonist based on the structure and conformation of a highly constrained cyclic RGD peptide

(E)-3-[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic Acid and Related Compounds: High Affinity Leukotriene B4 Receptor Antagonists

Preparation of some trimethylpentacyclo-[5.4.0.02,6.03,10.05,9]undecane-8,11-dione derivatives

The use of rabbit intestinal permeability as an in vitro assay in the search for orally active GPIIb/IIIa antagonists: In vitro models for selection of development candidates

Preparation of 1-substituted bicyclo[3.2.1]octanes by a rearrangement reaction

The use of rabbit intestinal permeability as an in vitro assay in the search for orally active GPIIb/IIIa antagonists

(E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]benzoic acid and related compounds : high affinity leukotriene B4 receptor antagonists

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