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Synergistic interaction between the two mechanisms of action of tapentadol in analgesia

The Journal of pharmacology and experimental therapeutics, 2011-04, Vol.337 (1), p.312-320

2011

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Neutral effects of the novel analgesic tapentadol on cardiac repolarization due to mixed ion channel inhibitory activities

Drug development research, 2010-05, Vol.71 (3), p.197-208

2010

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Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs

European journal of pharmacology, 2005-04, Vol.512 (1), p.53-60

2005

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711 ANTI-ALLODYNIC ACTIVITY OF TAPENTADOL IN A RAT MODEL OF NEUROPATHIC PAIN DEPENDS ON OPIOID AND NORADRENERGIC, BUT NOT SEROTONERGIC, MECHANISMS

European journal of pain, 2009-09, Vol.13 (S1), p.S205-S205

2009

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Tapentadol: with two mechanisms of action in one molecule effective against nociceptive and neuropathic pain. Preclinical overview

Schmerz (Berlin, Germany), 2011-02, Vol.25 (1), p.19

2011

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Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain

European journal of pain, 2010-09, Vol.14 (8), p.814-821

2010

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Tapentadol hydrochloride: a next-generation, centrally acting analgesic with two mechanisms of action in a single molecule

Drugs of Today, 2009-07, Vol.45 (7), p.483

2009

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Tapentadol: mit zwei Mechanismen in einem Molekül wirksam gegen nozizeptive und neuropathische Schmerzen: Präklinischer Überblick

Schmerz (Berlin, Germany), 2011-02, Vol.25 (1), p.19-25

2011

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Comparative Effects of Chlormadinone Acetate and Its 3α- and 3β-Hydroxy Metabolites on Progesterone, Androgen and Glucocorticoid Receptors

Pharmacology, 2009-01, Vol.84 (2), p.74-81

2009

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Further investigations into the genotoxicity of 2,6-xylidine and one of its key metabolites

Regulatory toxicology and pharmacology, 2012-02, Vol.62 (1), p.151-159

2012

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Comparative Effects of Chlormadinone Acetate and Its 3[alpha]- and 3[beta]-Hydroxy Metabolites on Progesterone, Androgen and Glucocorticoid Receptors

Pharmacology, 2009-08, Vol.84 (2), p.74

2009

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Mechanical and Electrophysiological Effects of Cromakalim on the Human Urinary Bladder

European urology, 1994-01, Vol.26 (2), p.176-181

1994

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Unterschiedliche Beteiligung opioiderger und noradrenerger Mechanismen an der antinozizeptiven und antiallodynischen Wirksamkeit von Tapentadol in Rattenmodellen nozizeptiver und neuropathischer Schmerzen

Zeitschrift für Palliativmedizin, 2010, Vol.11 (5)

2010

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Depolarization-induced influx of sodium in response to phenylephrine in rat atrial heart muscle

The Journal of physiology, 1991-01, Vol.432 (1), p.621-637

1991

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Characterization of adenosine receptors in guinea‐pig isolated left atria

British journal of pharmacology, 1989-08, Vol.97 (4), p.1182-1190

1989

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Comparative effects of chlormadinone acetate and its 3alpha- and 3beta-hydroxy metabolites on progesterone, androgen and glucocorticoid receptors

Pharmacology, 2009, Vol.84 (2), p.74-81

2009

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(686): Tapentadol HCl: In vitro and in vivo studies on the dual mechanism of action underlying its broad analgesic profile

The journal of pain, 2006-04, Vol.7 (4), p.S25-S25

2006

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686

The journal of pain, 2006-04, Vol.7 (4), p.S25

2006

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The antigen self-presentation function of the cytotoxic T-cell clone 10BK.1 depends on reciprocal peptide presentation

Immunology, 1994-03, Vol.81 (3), p.333-337

1994

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196 TAPENTADOL, A NOVEL CENTRALLY ACTING ANALGESIC: PRECLINICAL EVIDENCE FOR A DUAL MODE OF ACTION UNDERLYING ITS BROAD EFFICACY PROFILE

European journal of pain, 2006-09, Vol.10 (S1), p.S54-S54

2006

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Different mechanisms of the inhibition of the transient outward current in rat ventricular myocytes

Naunyn-Schmiedeberg's archives of pharmacology, 1994-01, Vol.349 (1), p.87-94

1994

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Positive inotropic response to 5-HT in human atrial but not in ventricular heart muscle

Naunyn-Schmiedeberg's archives of pharmacology, 1992-11, Vol.346 (5), p.482-485

1992

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L-type calcium channel activity in human atrial myocytes as influenced by 5-HT

Naunyn-Schmiedeberg's archives of pharmacology, 1993-10, Vol.348 (4), p.396-402

1993

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Differential electrophysiologic and inotropic effects of phenylephrine in atrial and ventricular heart muscle preparations from rats

Naunyn-Schmiedeberg's archives of pharmacology, 1991-11, Vol.344 (5), p.574-581

1991

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On the mechanism of action of phenylephrine in rat atrial heart muscle

Naunyn-Schmiedeberg's archives of pharmacology, 1994-04, Vol.349 (4), p.408-415

1994

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Synergistic interaction between the two mechanisms of action of tapentadol in analgesia

Neutral effects of the novel analgesic tapentadol on cardiac repolarization due to mixed ion channel inhibitory activities

Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs

711 ANTI-ALLODYNIC ACTIVITY OF TAPENTADOL IN A RAT MODEL OF NEUROPATHIC PAIN DEPENDS ON OPIOID AND NORADRENERGIC, BUT NOT SEROTONERGIC, MECHANISMS

Tapentadol: with two mechanisms of action in one molecule effective against nociceptive and neuropathic pain. Preclinical overview

Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain

Tapentadol hydrochloride: a next-generation, centrally acting analgesic with two mechanisms of action in a single molecule

Tapentadol: mit zwei Mechanismen in einem Molekül wirksam gegen nozizeptive und neuropathische Schmerzen: Präklinischer Überblick

Comparative Effects of Chlormadinone Acetate and Its 3α- and 3β-Hydroxy Metabolites on Progesterone, Androgen and Glucocorticoid Receptors

Further investigations into the genotoxicity of 2,6-xylidine and one of its key metabolites

Comparative Effects of Chlormadinone Acetate and Its 3[alpha]- and 3[beta]-Hydroxy Metabolites on Progesterone, Androgen and Glucocorticoid Receptors

Mechanical and Electrophysiological Effects of Cromakalim on the Human Urinary Bladder

Unterschiedliche Beteiligung opioiderger und noradrenerger Mechanismen an der antinozizeptiven und antiallodynischen Wirksamkeit von Tapentadol in Rattenmodellen nozizeptiver und neuropathischer Schmerzen

Depolarization-induced influx of sodium in response to phenylephrine in rat atrial heart muscle

Characterization of adenosine receptors in guinea‐pig isolated left atria

Comparative effects of chlormadinone acetate and its 3alpha- and 3beta-hydroxy metabolites on progesterone, androgen and glucocorticoid receptors

(686): Tapentadol HCl: In vitro and in vivo studies on the dual mechanism of action underlying its broad analgesic profile

686

The antigen self-presentation function of the cytotoxic T-cell clone 10BK.1 depends on reciprocal peptide presentation

196 TAPENTADOL, A NOVEL CENTRALLY ACTING ANALGESIC: PRECLINICAL EVIDENCE FOR A DUAL MODE OF ACTION UNDERLYING ITS BROAD EFFICACY PROFILE

Different mechanisms of the inhibition of the transient outward current in rat ventricular myocytes

Positive inotropic response to 5-HT in human atrial but not in ventricular heart muscle

L-type calcium channel activity in human atrial myocytes as influenced by 5-HT

Differential electrophysiologic and inotropic effects of phenylephrine in atrial and ventricular heart muscle preparations from rats

On the mechanism of action of phenylephrine in rat atrial heart muscle

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