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Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

Molecular neurodegeneration, 2017-05, Vol.12 (1), p.39-16, Article 39

2017

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Discovery of MK-8719, a Potent O‑GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

Journal of medicinal chemistry, 2019-11, Vol.62 (22), p.10062-10097

2019

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Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy

PloS one, 2018-04, Vol.13 (4), p.e0195486-e0195486

2018

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Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6

Journal of bone and mineral research, 2004-12, Vol.19 (12), p.2033-2040

2004

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Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

Molecular neurodegeneration, 2015-03, Vol.10 (1), p.14-14, Article 14

2015

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Allosteric Modulation of Group III Metabotropic Glutamate Receptor 4: A Potential Approach to Parkinson's Disease Treatment

Proceedings of the National Academy of Sciences - PNAS, 2003-11, Vol.100 (23), p.13668-13673

2003

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Attenuation of scratch‐induced reactive astrogliosis by novel EphA4 kinase inhibitors

Journal of neurochemistry, 2011-09, Vol.118 (6), p.1016-1031

2011

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MK-8719, a Novel and Selective O -GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy

The Journal of pharmacology and experimental therapeutics, 2020-08, Vol.374 (2), p.252-263

2020

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Genome-Wide Microarray Analysis of the Differential Neuroprotective Effects of Antioxidants in Neuroblastoma Cells Overexpressing the Familial Parkinson’s Disease α-Synuclein A53T Mutation

Neurochemical research, 2010, Vol.35 (1), p.130-142

2010

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Disruption of the Keap1-containing ubiquitination complex as an antioxidant therapy

Current topics in medicinal chemistry, 2007-05, Vol.7 (10), p.972-978

2007

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The NOD Idd9 Genetic Interval Influences the Pathogenicity of Insulitis and Contains Molecular Variants of Cd30, Tnfr2, and Cd137

Immunity (Cambridge, Mass.), 2000-07, Vol.13 (1), p.107-115

2000

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The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin

The Journal of pharmacology and experimental therapeutics, 2002-01, Vol.300 (1), p.305-313

2002

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Discovery of a Potent, Non-peptide Bradykinin B1 Receptor Antagonist

Journal of the American Chemical Society, 2003-06, Vol.125 (25), p.7516-7517

2003

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Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene

Genome research, 2003-05, Vol.13 (5), p.845-855

2003

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Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model

The Journal of pharmacology and experimental therapeutics, 2004-08, Vol.310 (2), p.488-497

2004

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Leptin receptor missense mutation in the fatty Zucker rat

Nature genetics, 1996-05, Vol.13 (1), p.18-19

1996

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Conserved Aspartate Residues and Phosphorylation in Signal Transduction by the Chemotaxis Protein CheY

Proceedings of the National Academy of Sciences - PNAS, 1990-01, Vol.87 (1), p.41-45

1990

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Increased nuclear factor‐erythroid 2 p45‐related factor 2 activity protects SH‐SY5Y cells against oxidative damage

Journal of neurochemistry, 2005-10, Vol.95 (2), p.406-417

2005

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Development of Orally Bioavailable and CNS Penetrant Biphenylaminocyclopropane Carboxamide Bradykinin B1 Receptor Antagonists

Journal of medicinal chemistry, 2007-01, Vol.50 (2), p.272-282

2007

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Targeting the metabotropic glutamate receptor mGluR4 for the treatment of diseases of the central nervous system

Current topics in medicinal chemistry, 2005-08, Vol.5 (9), p.885-895

2005

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Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor

Biochemical and biophysical research communications, 1992-04, Vol.184 (1), p.260-268

1992

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Targeted Disruption of a B2 Bradykinin Receptor Gene in Mice Eliminates Bradykinin Action in Smooth Muscle and Neurons

The Journal of biological chemistry, 1995-06, Vol.270 (23), p.13706-13710

1995

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Identification of the Critical Residues of Bradykinin Receptor B1 for Interaction with the Kinins Guided by Site-Directed Mutagenesis and Molecular Modeling

Biochemistry (Easton), 2006-12, Vol.45 (48), p.14355-14361

2006

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PISA, A novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ

Journal of pharmacological and toxicological methods, 2010-05, Vol.61 (3), p.319-328

2010

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Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

Discovery of MK-8719, a Potent O‑GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy

Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6

Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

Allosteric Modulation of Group III Metabotropic Glutamate Receptor 4: A Potential Approach to Parkinson's Disease Treatment

Attenuation of scratch‐induced reactive astrogliosis by novel EphA4 kinase inhibitors

MK-8719, a Novel and Selective O -GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy

Discovery of 6‑(Fluoro-18 F)‑3-(1H‑pyrrolo[2,3‑c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

Genome-Wide Microarray Analysis of the Differential Neuroprotective Effects of Antioxidants in Neuroblastoma Cells Overexpressing the Familial Parkinson’s Disease α-Synuclein A53T Mutation

Disruption of the Keap1-containing ubiquitination complex as an antioxidant therapy

The NOD Idd9 Genetic Interval Influences the Pathogenicity of Insulitis and Contains Molecular Variants of Cd30, Tnfr2, and Cd137

The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin

Discovery of a Potent, Non-peptide Bradykinin B1 Receptor Antagonist

Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene

Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model

Leptin receptor missense mutation in the fatty Zucker rat

Conserved Aspartate Residues and Phosphorylation in Signal Transduction by the Chemotaxis Protein CheY

Increased nuclear factor‐erythroid 2 p45‐related factor 2 activity protects SH‐SY5Y cells against oxidative damage

Development of Orally Bioavailable and CNS Penetrant Biphenylaminocyclopropane Carboxamide Bradykinin B1 Receptor Antagonists

Targeting the metabotropic glutamate receptor mGluR4 for the treatment of diseases of the central nervous system

Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor

Targeted Disruption of a B2 Bradykinin Receptor Gene in Mice Eliminates Bradykinin Action in Smooth Muscle and Neurons

Identification of the Critical Residues of Bradykinin Receptor B1 for Interaction with the Kinins Guided by Site-Directed Mutagenesis and Molecular Modeling

PISA, A novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ

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