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Inhibitors of the mitochondrial calcium uniporter for the treatment of disease

Current opinion in chemical biology, 2020-04, Vol.55, p.9-18

2020

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Implementing f‑Block Metal Ions in Medicine: Tuning the Size Selectivity of Expanded Macrocycles

Inorganic chemistry, 2019-08, Vol.58 (16), p.10483-10500

2019

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Redox Stability Controls the Cellular Uptake and Activity of Ruthenium‐Based Inhibitors of the Mitochondrial Calcium Uniporter (MCU)

Angewandte Chemie (International ed.), 2020-04, Vol.59 (16), p.6482-6491

International ed. in English, 2020

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Tuning the Kinetic Inertness of Bi3+ Complexes: The Impact of Donor Atoms on Diaza-18-Crown‑6 Ligands as Chelators for 213Bi Targeted Alpha Therapy

Inorganic chemistry, 2021-06, Vol.60 (12), p.9199-9211

2021

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Macrocyclic 1,2-Hydroxypyridinone-Based Chelators as Potential Ligands for Thorium-227 and Zirconium-89 Radiopharmaceuticals

Inorganic chemistry, 2023-12, Vol.62 (50), p.20721-20732

2023

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Actinium chelation and crystallization in a macromolecular scaffold

Nature communications, 2024-07, Vol.15 (1), p.5741-8, Article 5741

2024

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A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

ACS central science, 2019-01, Vol.5 (1), p.153-166

2019

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Characterization and Biological Activity of a Hydrogen Sulfide-Releasing Red Light-Activated Ruthenium(II) Complex

Journal of the American Chemical Society, 2018-10, Vol.140 (39), p.12383-12387

2018

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A Dinuclear Persulfide‐Bridged Ruthenium Compound is a Hypoxia‐Selective Hydrogen Sulfide (H2S) Donor

Angewandte Chemie (International ed.), 2021-01, Vol.60 (3), p.1588-1592

International ed. in English, 2021

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Tuning the Separation of Light Lanthanides Using a Reverse-Size Selective Aqueous Complexant

Inorganic chemistry, 2020-11, Vol.59 (22), p.16522-16530

2020

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A [1H,15N] Heteronuclear Single Quantum Coherence NMR Study of the Solution Reactivity of the Ruthenium‐Based Mitochondrial Calcium Uniporter Inhibitor Ru265

European journal of inorganic chemistry, 2022-02, Vol.2022 (6), p.n/a

2022

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Carboxylate-Capped Analogues of Ru265 Are MCU Inhibitor Prodrugs

Inorganic chemistry, 2022-10, Vol.61 (43), p.17299-17312

2022

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Towards the stable chelation of radium for biomedical applications with an 18-membered macrocyclic ligand

Chemical science (Cambridge), 2021-01, Vol.12 (1), p.3733-3742

2021

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Exploring the In Vivo and In Vitro Anticancer Activity of Rhenium Isonitrile Complexes

Inorganic chemistry, 2020-07, Vol.59 (14), p.10285-10303

2020

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A Rhenium Isonitrile Complex Induces Unfolded Protein Response‐Mediated Apoptosis in Cancer Cells

Chemistry : a European journal, 2019-07, Vol.25 (39), p.9206-9210

2019

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Accessing lanthanide-based, in situ illuminated optical turn-on probes by modulation of the antenna triplet state energy

Chemical science (Cambridge), 2021-07, Vol.12 (27), p.9442-9451

2021

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Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter

Chemical communications (Cambridge, England), 2021-06, Vol.57 (5), p.6161-6164

2021

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Photochemistry and in vitro anticancer activity of Pt(IV)Re(I) conjugates

Chemical communications (Cambridge, England), 2021-10, Vol.57 (85), p.11189-11192

2021

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Biocompatible metal-organic frameworks for the storage and therapeutic delivery of hydrogen sulfide

Chemical science (Cambridge), 2021-06, Vol.12 (22), p.7848-7857

2021

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Transdermal Hydrogen Sulfide Delivery Enabled by Open-Metal-Site Metal–Organic Frameworks

Journal of the American Chemical Society, 2024-07, Vol.146 (28), p.18927-18937

2024

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Ligand-Assisted Direct Lithography of Upconverting and Avalanching Nanoparticles for Nonlinear Photonics

Journal of the American Chemical Society, 2024-03, Vol.146 (11), p.7487-7497

2024

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Stable Chelation of the Uranyl Ion by Acyclic Hexadentate Ligands: Potential Applications for 230U Targeted α‑Therapy

Inorganic chemistry, 2022-02, Vol.61 (7), p.3337-3350

2022

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Stable Chelation of the Uranyl Ion by Acyclic Hexadentate Ligands: Potential Applications for 230 U Targeted α-Therapy

Inorganic chemistry, 2022-02, Vol.61 (7), p.3337-3350

2022

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Dinuclear nitrido-bridged osmium complexes inhibit the mitochondrial calcium uniporter and protect cortical neurons against lethal oxygen-glucose deprivation

RSC chemical biology, 2023-01, Vol.4 (1), p.84-93

2023

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A Dinuclear Persulfide‐Bridged Ruthenium Compound is a Hypoxia‐Selective Hydrogen Sulfide (H2S) Donor

Angewandte Chemie, 2021-01, Vol.133 (3), p.1612-1616

2021

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Inhibitors of the mitochondrial calcium uniporter for the treatment of disease

Implementing f‑Block Metal Ions in Medicine: Tuning the Size Selectivity of Expanded Macrocycles

Redox Stability Controls the Cellular Uptake and Activity of Ruthenium‐Based Inhibitors of the Mitochondrial Calcium Uniporter (MCU)

Tuning the Kinetic Inertness of Bi3+ Complexes: The Impact of Donor Atoms on Diaza-18-Crown‑6 Ligands as Chelators for 213Bi Targeted Alpha Therapy

Macrocyclic 1,2-Hydroxypyridinone-Based Chelators as Potential Ligands for Thorium-227 and Zirconium-89 Radiopharmaceuticals

Actinium chelation and crystallization in a macromolecular scaffold

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

Characterization and Biological Activity of a Hydrogen Sulfide-Releasing Red Light-Activated Ruthenium(II) Complex

A Dinuclear Persulfide‐Bridged Ruthenium Compound is a Hypoxia‐Selective Hydrogen Sulfide (H2S) Donor

Tuning the Separation of Light Lanthanides Using a Reverse-Size Selective Aqueous Complexant

A [1H,15N] Heteronuclear Single Quantum Coherence NMR Study of the Solution Reactivity of the Ruthenium‐Based Mitochondrial Calcium Uniporter Inhibitor Ru265

Carboxylate-Capped Analogues of Ru265 Are MCU Inhibitor Prodrugs

Towards the stable chelation of radium for biomedical applications with an 18-membered macrocyclic ligand

Exploring the In Vivo and In Vitro Anticancer Activity of Rhenium Isonitrile Complexes

A Rhenium Isonitrile Complex Induces Unfolded Protein Response‐Mediated Apoptosis in Cancer Cells

Accessing lanthanide-based, in situ illuminated optical turn-on probes by modulation of the antenna triplet state energy

Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter

Photochemistry and in vitro anticancer activity of Pt(IV)Re(I) conjugates

Biocompatible metal-organic frameworks for the storage and therapeutic delivery of hydrogen sulfide

Transdermal Hydrogen Sulfide Delivery Enabled by Open-Metal-Site Metal–Organic Frameworks

Ligand-Assisted Direct Lithography of Upconverting and Avalanching Nanoparticles for Nonlinear Photonics

Stable Chelation of the Uranyl Ion by Acyclic Hexadentate Ligands: Potential Applications for 230U Targeted α‑Therapy

Stable Chelation of the Uranyl Ion by Acyclic Hexadentate Ligands: Potential Applications for 230 U Targeted α-Therapy

Dinuclear nitrido-bridged osmium complexes inhibit the mitochondrial calcium uniporter and protect cortical neurons against lethal oxygen-glucose deprivation

A Dinuclear Persulfide‐Bridged Ruthenium Compound is a Hypoxia‐Selective Hydrogen Sulfide (H2S) Donor

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