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Thrombin functions as an inflammatory mediator through activation of its receptor

The Journal of experimental medicine, 1996-03, Vol.183 (3), p.821-827

1996

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Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin

Biochemistry (Easton), 1990-07, Vol.29 (30), p.7095-7101

1990

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Anticoagulant Activity of Synthetic Hirudin Peptides

The Journal of biological chemistry, 1989-05, Vol.264 (15), p.8692-8698

1989

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Structure of the hirugen and hirulog 1 complexes of α-thrombin

Journal of molecular biology, 1991-10, Vol.221 (4), p.1379-1393

1991

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Thrombin, thrombin inhibitors, and the arterial thrombotic process

Thrombosis and haemostasis, 1993-07, Vol.70 (1), p.208-211

Maraganore, J M

1993

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Thrombin-specific inhibition by and slow cleavage of hirulog-1

Biochemical journal, 1992-05, Vol.283 (3), p.737-743

1992

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Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor

Biochemistry (Easton), 1992-07, Vol.31 (27), p.6175-6178

1992

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Antithrombotic Effects of Synthetic Peptides Targeting Various Functional Domains of Thrombin

Proceedings of the National Academy of Sciences - PNAS, 1992-07, Vol.89 (13), p.6040-6044

1992

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The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen

The Journal of biological chemistry, 1990-08, Vol.265 (23), p.13484-13489

1990

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The lysine-49 phospholipase A2 from the venom of Agkistrodon piscivorus piscivorus. Relation of structure and function to other phospholipases A2

The Journal of biological chemistry, 1986-04, Vol.261 (11), p.4797-4804

1986

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A new class of phospholipases A2 with lysine in place of aspartate 49. Functional consequences for calcium and substrate binding

The Journal of biological chemistry, 1984-11, Vol.259 (22), p.13839-13843

1984

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Purification and characterization of trichosanthin. Homology to the ricin A chain and implications as to mechanism of abortifacient activity

The Journal of biological chemistry, 1987-08, Vol.262 (24), p.11628-11633

1987

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Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors

Biochemistry (Easton), 1992-12, Vol.31 (47), p.11689-11697

1992

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Inhibition of Coagulation and Thrombin-Induced Platelet Activities by a Synthetic Dodecapeptide Modeled on the Carboxy-Terminus of Hirudin

Blood, 1990-01, Vol.75 (2), p.399-406

1990

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Agkistrodon piscivorus piscivorus Platelet Aggregation Inhibitor: A Potent Inhibitor of Platelet Activation

Proceedings of the National Academy of Sciences - PNAS, 1989-10, Vol.86 (20), p.8050-8054

1989

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Anticoagulant effects of hirulog, a novel thrombin inhibitor, in patients with coronary artery disease

The American journal of cardiology, 1993-04, Vol.71 (10), p.778-782

1993

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Structural and functional properties of a phospholipase A2 purified from an inflammatory exudate

Biochemistry (Easton), 1986-12, Vol.25 (26), p.8381-8385

1986

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Binding of the snake venom-derived proteins applaggin and echistatin to the arginine-glycine-aspartic acid recognition site(s) on platelet glycoprotein IIb.IIIa complex inhibits receptor function

The Journal of biological chemistry, 1990-07, Vol.265 (20), p.11766-11772

1990

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Thrombin structure and function: why thrombin is the primary target for antithrombotics

Blood coagulation & fibrinolysis, 1991-02, Vol.2 (1), p.69-76

1991

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Systemic thrombin inhibition by Hirulog does not alter medial smooth muscle cell proliferation and inflammatory activation after vascular injury in the rabbit

Cardiovascular drugs and therapy, 1999-09, Vol.13 (5), p.429-434

1999

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A 113-Amino Acid Fragment of CD4 Produced in Escherichia Coli Blocks Human Immunodeficiency Virus-induced Cell Fusion

The Journal of biological chemistry, 1989-04, Vol.264 (10), p.5812-5817

1989

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Hirulog peptides with scissile bond replacements resistant to thrombin cleavage

Biochemical and biophysical research communications, 1991-06, Vol.177 (3), p.1049-1055

1991

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Selective Inhibition by a Synthetic Hirudin Peptide of Fibrin-Dependent Thrombosis in Baboons

Proceedings of the National Academy of Sciences - PNAS, 1991-02, Vol.88 (4), p.1177-1181

1991

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Hirulog-1 and -B2 thrombin specificity

Biochemical journal, 1992-10, Vol.287 (2), p.663-664

1992

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Hirudin-based peptides block the inflammatory effects of thrombin on endothelial cells

The Journal of biological chemistry, 1990-06, Vol.265 (17), p.9614-9616

1990

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Thrombin functions as an inflammatory mediator through activation of its receptor

Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin

Anticoagulant Activity of Synthetic Hirudin Peptides

Structure of the hirugen and hirulog 1 complexes of α-thrombin

Thrombin, thrombin inhibitors, and the arterial thrombotic process

Thrombin-specific inhibition by and slow cleavage of hirulog-1

Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor

Antithrombotic Effects of Synthetic Peptides Targeting Various Functional Domains of Thrombin

The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen

The lysine-49 phospholipase A2 from the venom of Agkistrodon piscivorus piscivorus. Relation of structure and function to other phospholipases A2

A new class of phospholipases A2 with lysine in place of aspartate 49. Functional consequences for calcium and substrate binding

Purification and characterization of trichosanthin. Homology to the ricin A chain and implications as to mechanism of abortifacient activity

Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors

Inhibition of Coagulation and Thrombin-Induced Platelet Activities by a Synthetic Dodecapeptide Modeled on the Carboxy-Terminus of Hirudin

Agkistrodon piscivorus piscivorus Platelet Aggregation Inhibitor: A Potent Inhibitor of Platelet Activation

Anticoagulant effects of hirulog, a novel thrombin inhibitor, in patients with coronary artery disease

Structural and functional properties of a phospholipase A2 purified from an inflammatory exudate

Binding of the snake venom-derived proteins applaggin and echistatin to the arginine-glycine-aspartic acid recognition site(s) on platelet glycoprotein IIb.IIIa complex inhibits receptor function

Thrombin structure and function: why thrombin is the primary target for antithrombotics

Systemic thrombin inhibition by Hirulog does not alter medial smooth muscle cell proliferation and inflammatory activation after vascular injury in the rabbit

A 113-Amino Acid Fragment of CD4 Produced in Escherichia Coli Blocks Human Immunodeficiency Virus-induced Cell Fusion

Hirulog peptides with scissile bond replacements resistant to thrombin cleavage

Selective Inhibition by a Synthetic Hirudin Peptide of Fibrin-Dependent Thrombosis in Baboons

Hirulog-1 and -B2 thrombin specificity

Hirudin-based peptides block the inflammatory effects of thrombin on endothelial cells

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