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Click Chemistry: Reaction Rates and Their Suitability for Biomedical Applications

Bioconjugate chemistry, 2024-06, Vol.35 (6), p.715-731

2024

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The application of targeted protein degradation technologies to G protein‐coupled receptors

British journal of pharmacology, 2024-07, Vol.181 (14), p.2351-2358

2024

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Discovery of 2‑Methyl-5-(1H‑pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders

Journal of medicinal chemistry, 2024-08, Vol.67 (15), p.13286-13304

2024

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Chemical biology-based approaches to study adenosine A2A − dopamine D2 receptor heteromers

Purinergic signalling, 2022-12, Vol.18 (4), p.395-398

2022

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The dopamine D2 receptor dimer and its interaction with homobivalent antagonists: homology modeling, docking and molecular dynamics

Journal of molecular modeling, 2016-09, Vol.22 (9), p.203-14, Article 203

2016

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The Design, Synthesis, and Evaluation of Novel 9‑Arylxanthenedione-Based Allosteric Modulators for the δ-Opioid Receptor

Journal of medicinal chemistry, 2022-09, Vol.65 (18), p.12367-12385

2022

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The right tools for the job: the central role for next generation chemical probes and chemistry-based target deconvolution methods in phenotypic drug discovery

RSC medicinal chemistry, 2021-03, Vol.12 (5), p.646-665

2021

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The effect of two selective A1‐receptor agonists and the bitopic ligand VCP746 on heart rate and regional vascular conductance in conscious rats

British journal of pharmacology, 2020-01, Vol.177 (2), p.346-359

2020

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Guidelines for the Synthesis of Small-Molecule Irreversible Probes Targeting G Protein-Coupled Receptors

ChemMedChem, 2016-07, Vol.11 (14), p.1488-1498

2016

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Synthesis and Pharmacological Evaluation of Dual Acting Ligands Targeting the Adenosine A2A and Dopamine D2 Receptors for the Potential Treatment of Parkinson’s Disease

Journal of medicinal chemistry, 2015-01, Vol.58 (2), p.718-738

2015

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Novel Irreversible Agonists Acting at the A1 Adenosine Receptor

Journal of medicinal chemistry, 2016-12, Vol.59 (24), p.11182-11194

2016

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4‑Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor

Journal of medicinal chemistry, 2016-01, Vol.59 (1), p.388-409

2016

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Probe dependence of allosteric enhancers on the binding affinity of adenosine A1‐receptor agonists at rat and human A1‐receptors measured using NanoBRET

British journal of pharmacology, 2019-04, Vol.176 (7), p.864-878

2019

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Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR

European journal of medicinal chemistry, 2023-10, Vol.258, p.115588-115588, Article 115588

2023

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Probing the binding site of novel selective positive allosteric modulators at the M 1 muscarinic acetylcholine receptor

Biochemical pharmacology, 2018-08, Vol.154, p.243

2018

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A Structure-Activity Relationship Study of Bitopic N6-Substituted Adenosine Derivatives as Biased Adenosine A1 Receptor Agonists

Journal of medicinal chemistry, 2018-03, Vol.61 (5), p.2087-2103

2018

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New small molecule fluorescent probes for G protein-coupled receptors: valuable tools for drug discovery

Future medicinal chemistry, 2021-01, Vol.13 (1), p.63-90

2021

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Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity

Cell, 2017-02, Vol.168 (5), p.867-877.e13

2017

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Guidelines for the Synthesis of Small-Molecule Irreversible Probes Targeting GProtein-Coupled Receptors

ChemMedChem, 2016-07, Vol.11 (14), p.1488-1498

2016

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Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M 1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles

Journal of medicinal chemistry, 2018-04, Vol.61 (7), p.2875-2894

2018

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Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles

Journal of medicinal chemistry, 2018-04, Vol.61 (7), p.2875-2894

2018

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Development of Novel 4‐Arylpyridin‐2‐one and 6‐Arylpyrimidin‐4‐one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor

ChemMedChem, 2021-01, Vol.16 (1), p.216-233

2021

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Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors

Molecular pharmacology, 2018-07, Vol.94 (1), p.770

2018

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Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor

ACS chemical neuroscience, 2016-05, Vol.7 (5), p.647-661

2016

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NMR case study of ropinirole: concentration-dependent effects of nonexchangeable proton resonances

Magnetic resonance in chemistry, 2014-11, Vol.52 (11), p.715-718

2014

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Click Chemistry: Reaction Rates and Their Suitability for Biomedical Applications

The application of targeted protein degradation technologies to G protein‐coupled receptors

Discovery of 2‑Methyl-5-(1H‑pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders

Chemical biology-based approaches to study adenosine A2A − dopamine D2 receptor heteromers

The dopamine D2 receptor dimer and its interaction with homobivalent antagonists: homology modeling, docking and molecular dynamics

The Design, Synthesis, and Evaluation of Novel 9‑Arylxanthenedione-Based Allosteric Modulators for the δ-Opioid Receptor

The right tools for the job: the central role for next generation chemical probes and chemistry-based target deconvolution methods in phenotypic drug discovery

The effect of two selective A1‐receptor agonists and the bitopic ligand VCP746 on heart rate and regional vascular conductance in conscious rats

Guidelines for the Synthesis of Small-Molecule Irreversible Probes Targeting G Protein-Coupled Receptors

Synthesis and Pharmacological Evaluation of Dual Acting Ligands Targeting the Adenosine A2A and Dopamine D2 Receptors for the Potential Treatment of Parkinson’s Disease

Novel Irreversible Agonists Acting at the A1 Adenosine Receptor

4‑Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor

Probe dependence of allosteric enhancers on the binding affinity of adenosine A1‐receptor agonists at rat and human A1‐receptors measured using NanoBRET

Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR

Probing the binding site of novel selective positive allosteric modulators at the M 1 muscarinic acetylcholine receptor

A Structure-Activity Relationship Study of Bitopic N6-Substituted Adenosine Derivatives as Biased Adenosine A1 Receptor Agonists

New small molecule fluorescent probes for G protein-coupled receptors: valuable tools for drug discovery

Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity

Guidelines for the Synthesis of Small-Molecule Irreversible Probes Targeting GProtein-Coupled Receptors

Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M 1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles

Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles

Development of Novel 4‐Arylpyridin‐2‐one and 6‐Arylpyrimidin‐4‐one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor

Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors

Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor

NMR case study of ropinirole: concentration-dependent effects of nonexchangeable proton resonances

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