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Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety

Pharmaceutical research, 2021-04, Vol.38 (4), p.593-605

2021

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Pharmacokinetics and dose requirements of factor VIII over the age range 3-74 years

European journal of clinical pharmacology, 2009-06, Vol.65 (10), p.989-998

2009

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Model‐based evaluation of low‐dose factor VIII prophylaxis in haemophilia A

Haemophilia : the official journal of the World Federation of Hemophilia, 2019-05, Vol.25 (3), p.408-415

2019

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Population pharmacokinetics of cefotaxime in intensive care patients

European journal of clinical pharmacology, 2022-02, Vol.78 (2), p.251-258

2022

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Handling interoccasion variability in model‐based dose individualization using therapeutic drug monitoring data

British journal of clinical pharmacology, 2019-06, Vol.85 (6), p.1326-1336

2019

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Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time

International journal of antimicrobial agents, 2024-01, Vol.63 (1), p.107032-107032, Article 107032

2024

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Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

Haematologica (Roma), 2020-05, Vol.105 (5), p.1443-1453

2020

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Population pharmacokinetics of edoxaban and its main metabolite in a dedicated renal impairment study

Journal of clinical pharmacology, 2015-11, Vol.55 (11), p.1268-1279

2015

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Population pharmacokinetic and dose-response models of nepadutant, a selective antagonist of the NK2 receptors, in infants with colic

British journal of clinical pharmacology, 2024-09

2024

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Association between Sports Participation, Factor VIII Levels and Bleeding in Hemophilia A

Thrombosis and haemostasis, 2023-03, Vol.123 (3), p.317-325

2023

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Exploring Factors Causing Low Brain Penetration of the Opioid Peptide DAMGO through Experimental Methods and Modeling

Molecular pharmaceutics, 2016-04, Vol.13 (4), p.1258-1266

2016

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Characterization of anti-drug antibody dynamics using a bivariate mixed hidden-markov model by nonlinear-mixed effects approach

Journal of pharmacokinetics and pharmacodynamics, 2024-02, Vol.51 (1), p.65-75

2024

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Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL

Frontiers in pharmacology, 2024-10, Vol.15, p.1472662

2024

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Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab

Clinical cancer research, 2022-04, Vol.28 (7), p.1363-1371

2022

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Detecting placebo and drug effects on Parkinson's disease symptoms by longitudinal item‐score models

CPT: pharmacometrics and systems pharmacology, 2021-04, Vol.10 (4), p.309-317

2021

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A diagnostic tool for population models using non-compartmental analysis: The ncappc package for R

Computer methods and programs in biomedicine, 2016-04, Vol.127, p.83-93

2016

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Population Pharmacokinetics of Ethambutol in South African Tuberculosis Patients

Antimicrobial Agents and Chemotherapy, 2011-09, Vol.55 (9), p.4230-4237

2011

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A model‐based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno‐oncology

CPT: pharmacometrics and systems pharmacology, 2023-11, Vol.12 (11), p.1804-1818

2023

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A multistate modeling and simulation framework to learn dose–response of oncology drugs: Application to bintrafusp alfa in non‐small cell lung cancer

CPT: pharmacometrics and systems pharmacology, 2023-11, Vol.12 (11), p.1738-1750

2023

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Population Pharmacokinetics of Edoxaban in Patients with Non-Valvular Atrial Fibrillation in the ENGAGE AF-TIMI 48 Study, a Phase III Clinical Trial

Clinical pharmacokinetics, 2016-09, Vol.55 (9), p.1079-1090

2016

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Role of Modelling and Simulation: A European Regulatory Perspective

Clinical pharmacokinetics, 2012-01, Vol.51 (2), p.69-76

2012

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Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII

CPT: pharmacometrics and systems pharmacology, 2019-12, Vol.8 (12), p.894-903

2019

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Relationship between factor VIII levels and bleeding for rFVIII‐SingleChain in severe hemophilia A: A repeated time‐to‐event analysis

CPT: pharmacometrics and systems pharmacology, 2023-05, Vol.12 (5), p.706-718

2023

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Population pharmacokinetics of edoxaban in patients with symptomatic deep‐vein thrombosis and/or pulmonary embolism—the Hokusai‐VTE phase 3 study

British journal of clinical pharmacology, 2015-12, Vol.80 (6), p.1374-1387

2015

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A Prospective Population Pharmacokinetic Study on Morphine Metabolism in Cancer Patients

Clinical pharmacokinetics, 2017-07, Vol.56 (7), p.733-746

2017

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Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety

Pharmacokinetics and dose requirements of factor VIII over the age range 3-74 years

Model‐based evaluation of low‐dose factor VIII prophylaxis in haemophilia A

Population pharmacokinetics of cefotaxime in intensive care patients

Handling interoccasion variability in model‐based dose individualization using therapeutic drug monitoring data

Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time

Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

Population pharmacokinetics of edoxaban and its main metabolite in a dedicated renal impairment study

Population pharmacokinetic and dose-response models of nepadutant, a selective antagonist of the NK2 receptors, in infants with colic

Association between Sports Participation, Factor VIII Levels and Bleeding in Hemophilia A

Exploring Factors Causing Low Brain Penetration of the Opioid Peptide DAMGO through Experimental Methods and Modeling

Characterization of anti-drug antibody dynamics using a bivariate mixed hidden-markov model by nonlinear-mixed effects approach

Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL

Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab

Detecting placebo and drug effects on Parkinson's disease symptoms by longitudinal item‐score models

A diagnostic tool for population models using non-compartmental analysis: The ncappc package for R

Population Pharmacokinetics of Ethambutol in South African Tuberculosis Patients

A model‐based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno‐oncology

A multistate modeling and simulation framework to learn dose–response of oncology drugs: Application to bintrafusp alfa in non‐small cell lung cancer

Population Pharmacokinetics of Edoxaban in Patients with Non-Valvular Atrial Fibrillation in the ENGAGE AF-TIMI 48 Study, a Phase III Clinical Trial

Role of Modelling and Simulation: A European Regulatory Perspective

Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII

Relationship between factor VIII levels and bleeding for rFVIII‐SingleChain in severe hemophilia A: A repeated time‐to‐event analysis

Population pharmacokinetics of edoxaban in patients with symptomatic deep‐vein thrombosis and/or pulmonary embolism—the Hokusai‐VTE phase 3 study

A Prospective Population Pharmacokinetic Study on Morphine Metabolism in Cancer Patients

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