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Prodrugs: design and clinical applications

Nature reviews. Drug discovery, 2008-03, Vol.7 (3), p.255-270

2008

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Glucose Promoiety Enables Glucose Transporter Mediated Brain Uptake of Ketoprofen and Indomethacin Prodrugs in Rats

Journal of medicinal chemistry, 2009-05, Vol.52 (10), p.3348-3353

2009

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An In Silico Approach to Discovering Novel Inhibitors of Human Sirtuin Type 2

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6292-6298

2004

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Despite substantial degradation, 2‐arachidonoylglycerol is a potent full efficacy agonist mediating CB1 receptor‐dependent G‐protein activation in rat cerebellar membranes

British journal of pharmacology, 2001-10, Vol.134 (3), p.664-672

2001

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Virtual Screening of Novel CB2 Ligands Using a Comparative Model of the Human Cannabinoid CB2 Receptor

Journal of medicinal chemistry, 2005-11, Vol.48 (23), p.7166-7171

2005

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In vitro toxicity and permeation of cyclodextrins in Calu-3 cells

Journal of controlled release, 2008-02, Vol.126 (1), p.10-16

2008

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Cyclodextrins in drug delivery

Expert opinion on drug delivery, 2005-03, Vol.2 (2), p.335-351

2005

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The Effect of Cyclodextrins on Chemical and Physical Stability of Glucagon and Characterization of Glucagon/γ-CD Inclusion Complexes

Journal of pharmaceutical sciences, 2008-07, Vol.97 (7), p.2720-2729

2008

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The First Bioreversible Prodrug of Metformin with Improved Lipophilicity and Enhanced Intestinal Absorption

Journal of medicinal chemistry, 2009-07, Vol.52 (14), p.4142-4148

2009

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Antibacterial activity of methylated chitosan and chitooligomer derivatives: Synthesis and structure activity relationships

European polymer journal, 2007-06, Vol.43 (6), p.2660-2671

2007

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A Cyclopent-2-enecarbonyl Group Mimics Proline at the P2 Position of Prolyl Oligopeptidase Inhibitors

Journal of medicinal chemistry, 2004-11, Vol.47 (23), p.5605-5607

2004

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Cyclodextrins in ophthalmic drug delivery

Advanced drug delivery reviews, 1999-03, Vol.36 (1), p.59-79

1999

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Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat

The Journal of pharmacology and experimental therapeutics, 2003-02, Vol.304 (2), p.498-506

2003

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Antimicrobial activity of piperazine derivatives of chitosan

Carbohydrate polymers, 2008-11, Vol.74 (3), p.566-571

2008

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Precipitation Complexation Method Produces Cannabidiol/β-Cyclodextrin Inclusion Complex Suitable for Sublingual Administration of Cannabidiol

Journal of pharmaceutical sciences, 2007-02, Vol.96 (2), p.312-319

2007

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Antimicrobial activity of chitosan N-betainates

Carbohydrate polymers, 2006-07, Vol.65 (1), p.114-118

2006

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Ocular absorption following topical delivery

Advanced drug delivery reviews, 1995-08, Vol.16 (1), p.3-19

1995

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Effects of hempseed and flaxseed oils on the profile of serum lipids, serum total and lipoprotein lipid concentrations and haemostatic factors

European journal of nutrition, 2006-12, Vol.45 (8), p.470-477

2006

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Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid

Biochemical pharmacology, 2003-09, Vol.66 (5), p.757-767

2003

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Crystal structure changes of γ-cyclodextrin after the SEDS process in supercritical carbon dioxide affect the dissolution rate of complexed budesonide

Pharmaceutical research, 2007-06, Vol.24 (6), p.1058-1066

2007

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Bisphosphonate Prodrugs: Synthesis and in Vitro Evaluation of Novel Acyloxyalkyl Esters of Clodronic Acid

Journal of medicinal chemistry, 1999-12, Vol.42 (24), p.5053-5058

1999

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An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A 1 and cannabinoid CB 1 receptors

British journal of pharmacology, 2009-02, Vol.140 (8), p.1451-1459

2009

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Large Neutral Amino Acid Transporter Enables Brain Drug Delivery via Prodrugs

Journal of medicinal chemistry, 2008-02, Vol.51 (4), p.932-936

2008

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A novel synthetic route for the preparation of alkyl and benzyl chloromethyl phosphates

Tetrahedron letters, 2002-05, Vol.43 (21), p.3793-3794

2002

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In vivo studies on the antileishmanial activity of buparvaquone and its prodrugs

Journal of antimicrobial chemotherapy, 2007-10, Vol.60 (4), p.802-810

2007

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Prodrugs: design and clinical applications

Glucose Promoiety Enables Glucose Transporter Mediated Brain Uptake of Ketoprofen and Indomethacin Prodrugs in Rats

An In Silico Approach to Discovering Novel Inhibitors of Human Sirtuin Type 2

Despite substantial degradation, 2‐arachidonoylglycerol is a potent full efficacy agonist mediating CB1 receptor‐dependent G‐protein activation in rat cerebellar membranes

Virtual Screening of Novel CB2 Ligands Using a Comparative Model of the Human Cannabinoid CB2 Receptor

In vitro toxicity and permeation of cyclodextrins in Calu-3 cells

Cyclodextrins in drug delivery

The Effect of Cyclodextrins on Chemical and Physical Stability of Glucagon and Characterization of Glucagon/γ-CD Inclusion Complexes

The First Bioreversible Prodrug of Metformin with Improved Lipophilicity and Enhanced Intestinal Absorption

Antibacterial activity of methylated chitosan and chitooligomer derivatives: Synthesis and structure activity relationships

A Cyclopent-2-enecarbonyl Group Mimics Proline at the P2 Position of Prolyl Oligopeptidase Inhibitors

Cyclodextrins in ophthalmic drug delivery

Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat

Antimicrobial activity of piperazine derivatives of chitosan

Precipitation Complexation Method Produces Cannabidiol/β-Cyclodextrin Inclusion Complex Suitable for Sublingual Administration of Cannabidiol

Antimicrobial activity of chitosan N-betainates

Ocular absorption following topical delivery

Effects of hempseed and flaxseed oils on the profile of serum lipids, serum total and lipoprotein lipid concentrations and haemostatic factors

Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid

Crystal structure changes of γ-cyclodextrin after the SEDS process in supercritical carbon dioxide affect the dissolution rate of complexed budesonide

Bisphosphonate Prodrugs: Synthesis and in Vitro Evaluation of Novel Acyloxyalkyl Esters of Clodronic Acid

An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A 1 and cannabinoid CB 1 receptors

Large Neutral Amino Acid Transporter Enables Brain Drug Delivery via Prodrugs

A novel synthetic route for the preparation of alkyl and benzyl chloromethyl phosphates

In vivo studies on the antileishmanial activity of buparvaquone and its prodrugs

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