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Antiviral Efficacy and Host Immune Response Induction during Sequential Treatment with SB 9200 Followed by Entecavir in Woodchucks

PloS one, 2017-01, Vol.12 (1), p.e0169631

2017

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Antiviral Efficacy and Host Innate Immunity Associated with SB 9200 Treatment in the Woodchuck Model of Chronic Hepatitis B

PloS one, 2016-08, Vol.11 (8), p.e0161313

2016

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NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice

Frontiers in immunology, 2020-12, Vol.11, p.592333-592333

2020

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SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants

Journal of medical virology, 2017-09, Vol.89 (9), p.1620-1628

2017

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A phase 2, open‐label, randomized, multiple‐dose study evaluating Inarigivir in treatment‐naïve patients with chronic hepatitis B

Liver international, 2023-01, Vol.43 (1), p.77-89

2023

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Phosphorothioate Di- and Trinucleotides as a Novel Class of Anti-Hepatitis B Virus Agents

Antimicrobial Agents and Chemotherapy, 2004-06, Vol.48 (6), p.2199-2205

2004

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Nucleobase Protection of Deoxyribo‐ and Ribonucleosides

Current Protocols in Nucleic Acid Chemistry, 2017-06, Vol.69 (1), p.2.1.1-2.1.40

2017

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Anti-Hepatitis B Virus Activity of ORI-9020, a Novel Phosphorothioate Dinucleotide, in a Transgenic Mouse Model

Antimicrobial Agents and Chemotherapy, 2004-06, Vol.48 (6), p.2318-2320

2004

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Metabolism, pharmacokinetics, tissue distribution, and stability studies of the prodrug analog of an anti-hepatitis B virus dinucleoside phosphorothioate

Drug metabolism and disposition, 2012-05, Vol.40 (5), p.970-981

2012

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In silico optimization of pharmacokinetic properties and receptor binding affinity simultaneously: a 'parallel progression approach to drug design' applied to β-blockers

Journal of biomolecular structure & dynamics, 2016-01, Vol.34 (2), p.384-398

2016

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Ensemble QSAR: A QSAR method based on conformational ensembles and metric descriptors

Journal of computational chemistry, 2011-07, Vol.32 (10), p.2204-2218

2011

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The automated synthesis of sulfur-containing oligodeoxyribonucleotides using 3H-1,2-benzodithiol-3-one 1,1-dioxide as a sulfur-transfer reagent

Journal of organic chemistry, 1990-07, Vol.55 (15), p.4693-4699

1990

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Solid-phase stereoselective synthesis of oligonucleoside phosphorothioates: The nucleoside bicyclic oxazaphospholidines as novel synthons

Tetrahedron letters, 1998-04, Vol.39 (17), p.2491-2494

1998

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Diversity-oriented, one-pot, multi-component synthesis of substituted uracil derivatives

Molecular diversity, 2011-02, Vol.15 (1), p.263-267

2011

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Identification of new checkpoint kinase-1 (Chk1) inhibitors by docking, 3D-QSAR, and pharmacophore-modeling methods

Canadian journal of chemistry, 2012-08, Vol.90 (8), p.675-692

2012

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The Functionalization of Oligonucleotides Via Phosphoramidite Derivatives

Tetrahedron, 1993-03, Vol.49 (10), p.1925-1963

1993

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SB 11285 - a highly potent STING agonist for application in immuno-oncology

Immunome research, 2018, Vol.14

Iyer, Radhakrishnan P

2018

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Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1783-1786

2010

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Modified oligonucleotides as therapeutic and diagnostic agents

Current opinion in biotechnology, 1995, Vol.6 (1), p.12-19

1995

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Nucleotide analogs as novel anti-hepatitis B virus agents

Current opinion in pharmacology, 2005-10, Vol.5 (5), p.520-528

2005

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3H-1,2-Benzodithiole-3-one 1,1-dioxide as an improved sulfurizing reagent in the solid-phase synthesis of oligodeoxyribonucleoside phosphorothioates

Journal of the American Chemical Society, 1990, Vol.112 (3), p.1253-1254

1990

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Anti-HBV nucleotide prodrug analogs: Synthesis, bioreversibility, and cytotoxicity studies

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (6), p.1491-1494

2006

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A novel linker for the solid-phase synthesis of a library of 3′-thiophosphorylated dinucleotides

Tetrahedron letters, 2001-05, Vol.42 (22), p.3669-3672

2001

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The synthesis of specific ribonucleotides and unrelated phosphorylated biomolecules by the phosphoramidite method

Tetrahedron, 1993, Vol.49 (46), p.10441-10488

1993

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RAPID FUNCTIONALIZATION AND LOADING OF SOLID SUPPORTS

Organic preparations and procedures international, 2005-06, Vol.37 (3), p.205-212

2005

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Antiviral Efficacy and Host Immune Response Induction during Sequential Treatment with SB 9200 Followed by Entecavir in Woodchucks

Antiviral Efficacy and Host Innate Immunity Associated with SB 9200 Treatment in the Woodchuck Model of Chronic Hepatitis B

NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice

SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants

A phase 2, open‐label, randomized, multiple‐dose study evaluating Inarigivir in treatment‐naïve patients with chronic hepatitis B

Phosphorothioate Di- and Trinucleotides as a Novel Class of Anti-Hepatitis B Virus Agents

Nucleobase Protection of Deoxyribo‐ and Ribonucleosides

Anti-Hepatitis B Virus Activity of ORI-9020, a Novel Phosphorothioate Dinucleotide, in a Transgenic Mouse Model

Metabolism, pharmacokinetics, tissue distribution, and stability studies of the prodrug analog of an anti-hepatitis B virus dinucleoside phosphorothioate

In silico optimization of pharmacokinetic properties and receptor binding affinity simultaneously: a 'parallel progression approach to drug design' applied to β-blockers

Ensemble QSAR: A QSAR method based on conformational ensembles and metric descriptors

The automated synthesis of sulfur-containing oligodeoxyribonucleotides using 3H-1,2-benzodithiol-3-one 1,1-dioxide as a sulfur-transfer reagent

Solid-phase stereoselective synthesis of oligonucleoside phosphorothioates: The nucleoside bicyclic oxazaphospholidines as novel synthons

Diversity-oriented, one-pot, multi-component synthesis of substituted uracil derivatives

Identification of new checkpoint kinase-1 (Chk1) inhibitors by docking, 3D-QSAR, and pharmacophore-modeling methods

The Functionalization of Oligonucleotides Via Phosphoramidite Derivatives

SB 11285 - a highly potent STING agonist for application in immuno-oncology

Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs

Modified oligonucleotides as therapeutic and diagnostic agents

Nucleotide analogs as novel anti-hepatitis B virus agents

3H-1,2-Benzodithiole-3-one 1,1-dioxide as an improved sulfurizing reagent in the solid-phase synthesis of oligodeoxyribonucleoside phosphorothioates

Anti-HBV nucleotide prodrug analogs: Synthesis, bioreversibility, and cytotoxicity studies

A novel linker for the solid-phase synthesis of a library of 3′-thiophosphorylated dinucleotides

The synthesis of specific ribonucleotides and unrelated phosphorylated biomolecules by the phosphoramidite method

RAPID FUNCTIONALIZATION AND LOADING OF SOLID SUPPORTS

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