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The therapeutic potential of second and third generation CB1R antagonists

Pharmacology & therapeutics (Oxford), 2020-04, Vol.208, p.107477-107477, Article 107477

2020

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Crystal Structure of the Human Cannabinoid Receptor CB2

Cell, 2019-01, Vol.176 (3), p.459-467.e13

2019

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Pharmacological Evaluation of Cannabinoid Receptor Modulators Using GRABeCB2.0 Sensor

International journal of molecular sciences, 2024-05, Vol.25 (9), p.5012

2024

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Rational Design, Synthesis, and Evaluation of Fluorescent CB2 Receptor Ligands for Live-Cell Imaging: A Comprehensive Review

Pharmaceuticals (Basel, Switzerland), 2023-08, Vol.16 (9), p.1235

2023

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Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis

Cell metabolism, 2019-06, Vol.29 (6), p.1320-1333.e8

2019

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Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (45), p.11597-11602

2018

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Preclinical to Clinical Profile of Curcuma longa as Antidiabetic Therapeutics

Current topics in medicinal chemistry, 2023-01, Vol.23 (24), p.2267-2276

2023

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Evaluation of the Therapeutic Potential of Sulfonyl Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors

Molecules (Basel, Switzerland), 2024-06, Vol.29 (13), p.3036

2024

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Cholesterol as a modulator of cannabinoid receptor CB2 signaling

Scientific reports, 2021-02, Vol.11 (1), p.3706-3706, Article 3706

2021

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Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

Molecules (Basel, Switzerland), 2021-08, Vol.26 (16), p.5089

2021

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Peripheral Hybrid CB1R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis

Frontiers in endocrinology (Lausanne), 2021-09, Vol.12

2021

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Dual inhibition of CB1 receptors and iNOS, as a potential novel approach to the pharmacological management of acute and long COVID‐19

British journal of pharmacology, 2022-05, Vol.179 (10), p.2121-2127

2022

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Targeting Sterol O‑Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16062-16098

2022

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In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis

Biomedicine & pharmacotherapy, 2023-12, Vol.168, p.115178-115178, Article 115178

2023

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Dual inhibition of CB 1 receptors and iNOS, as a potential novel approach to the pharmacological management of acute and long COVID-19

British journal of pharmacology, 2022-05, Vol.179 (10), p.2121-2127

2022

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Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis

JCI insight, 2017-04, Vol.2 (8)

2017

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Probing the Conformational Space of the Cannabinoid Receptor 2 and a Systematic Investigation of DNP-Enhanced MAS NMR Spectroscopy of Proteins in Detergent Micelles

ACS omega, 2023-09, Vol.8 (36), p.32963-32976

2023

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Therapeutic approaches targeting the neurotensin receptors

Expert opinion on therapeutic patents, 2021-05, Vol.31 (5), p.361-386

2021

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A patent review on aldehyde dehydrogenase inhibitors: an overview of small molecule inhibitors from the last decade

Expert opinion on therapeutic patents, 2023-10, Vol.33 (10), p.651-668

2023

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Soluble epoxide hydrolase inhibitors: an overview and patent review from the last decade

Expert opinion on therapeutic patents, 2022-06, Vol.32 (6), p.629-647

2022

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CB1R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky–Pudlak syndrome

Clinical and translational medicine, 2021-07, Vol.11 (7), p.n/a

2021

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Promising Schiff bases in antiviral drug design and discovery

Medicinal chemistry research, 2023, Vol.32 (6), p.1063-1076

2023

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Dual inhibition of cannabinoid CB1 receptor and inducible NOS attenuates obesity‐induced chronic kidney disease

British journal of pharmacology, 2020-01, Vol.177 (1), p.110-127

2020

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Cannabinoformins: Designing Biguanide-Embedded, Orally Available, Peripherally Selective Cannabinoid‑1 Receptor Antagonists for Metabolic Syndrome Disorders

Journal of medicinal chemistry, 2023-09, Vol.66 (17), p.11985-12004

2023

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Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB1R Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis

Journal of medicinal chemistry, 2017-02, Vol.60 (3), p.1126-1141

2017

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The therapeutic potential of second and third generation CB1R antagonists

Crystal Structure of the Human Cannabinoid Receptor CB2

Pharmacological Evaluation of Cannabinoid Receptor Modulators Using GRABeCB2.0 Sensor

Rational Design, Synthesis, and Evaluation of Fluorescent CB2 Receptor Ligands for Live-Cell Imaging: A Comprehensive Review

Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis

Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist

Preclinical to Clinical Profile of Curcuma longa as Antidiabetic Therapeutics

Evaluation of the Therapeutic Potential of Sulfonyl Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors

Cholesterol as a modulator of cannabinoid receptor CB2 signaling

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

Peripheral Hybrid CB1R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis

Dual inhibition of CB1 receptors and iNOS, as a potential novel approach to the pharmacological management of acute and long COVID‐19

Targeting Sterol O‑Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential

In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis

Dual inhibition of CB 1 receptors and iNOS, as a potential novel approach to the pharmacological management of acute and long COVID-19

Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis

Probing the Conformational Space of the Cannabinoid Receptor 2 and a Systematic Investigation of DNP-Enhanced MAS NMR Spectroscopy of Proteins in Detergent Micelles

Therapeutic approaches targeting the neurotensin receptors

A patent review on aldehyde dehydrogenase inhibitors: an overview of small molecule inhibitors from the last decade

Soluble epoxide hydrolase inhibitors: an overview and patent review from the last decade

CB1R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky–Pudlak syndrome

Promising Schiff bases in antiviral drug design and discovery

Dual inhibition of cannabinoid CB1 receptor and inducible NOS attenuates obesity‐induced chronic kidney disease

Cannabinoformins: Designing Biguanide-Embedded, Orally Available, Peripherally Selective Cannabinoid‑1 Receptor Antagonists for Metabolic Syndrome Disorders

Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB1R Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis

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