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Metabolite safety in drug development

2016

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The cardiolipin–cytochrome c interaction and the mitochondrial regulation of apoptosis

Archives of Biochemistry and Biophysics, 2004-03, Vol.423 (1), p.37-46

2004

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Mapping Drug Distribution in Brain Tissue Using Liquid Extraction Surface Analysis Mass Spectrometry Imaging

Analytical chemistry (Washington), 2015-10, Vol.87 (19), p.10146-10152

2015

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Qualitative and Quantitative MALDI Imaging of the Positron Emission Tomography Ligands Raclopride (a D2 Dopamine Antagonist) and SCH 23390 (a D1 Dopamine Antagonist) in Rat Brain Tissue Sections Using a Solvent-Free Dry Matrix Application Method

Analytical chemistry (Washington), 2011-12, Vol.83 (24), p.9694-9701

2011

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Exemplifying the Screening Power of Mass Spectrometry Imaging over Label-Based Technologies for Simultaneous Monitoring of Drug and Metabolite Distributions in Tissue Sections

Journal of biomolecular screening, 2016-02, Vol.21 (2), p.187-193

2016

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Cardiolipin Is Not Required for Bax-mediated Cytochrome c Release from Yeast Mitochondria

The Journal of biological chemistry, 2004-01, Vol.279 (2), p.1100-1107

2004

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Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation

Journal of proteomics, 2012-08, Vol.75 (16), p.4912-4920

2012

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Pragmatic Approaches to Determine the Exposures of Drug Metabolites in Preclinical and Clinical Subjects in the MIST Evaluation of the Clinical Development Phase

Chemical research in toxicology, 2014-04, Vol.27 (4), p.601-610

2014

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The significance of ambient-temperature on pharmaceutical and endogenous compound abundance and distribution in tissues sections when analyzed by matrix-assisted laser desorption/ionization mass spectrometry imaging

Rapid communications in mass spectrometry, 2012-03, Vol.26 (5), p.494-498

2012

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Identification of a Reactive Metabolite of Terbinafine: Insights into Terbinafine-Induced Hepatotoxicity

Chemical research in toxicology, 2001-02, Vol.14 (2), p.175-181

2001

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Bioactivation of Estrone and Its Catechol Metabolites to Quinoid−Glutathione Conjugates in Rat Liver Microsomes

Chemical research in toxicology, 1996, Vol.9 (2), p.492-499

1996

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The Influence of the p-Alkyl Substituent on the Isomerization of o-Quinones to p-Quinone Methides: Potential Bioactivation Mechanism for Catechols

Chemical research in toxicology, 1995-06, Vol.8 (4), p.537-544

1995

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INTRODUCTION TO CASE STUDIES

Metabolite Safety in Drug Development, 2016, p.239-242

2016

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The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells

Chemico-biological interactions, 1997-09, Vol.106 (2), p.133-148

1997

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Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation: Imaging Mass Spectrometry: A User's Guide to a New Technique for Biological and Biomedical Research

Journal of proteomics, 2012, Vol.75 (16), p.4912-4920

2012

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“MIST” AND OTHER METABOLITE GUIDELINES IN THE CONTEXT OF INDUSTRIAL DRUG METABOLISM

Metabolite Safety in Drug Development, 2016, p.17-43

2016

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A MASS BALANCE AND METABOLITE PROFILING STUDY OF SONIDEGIB IN HEALTHY MALE SUBJECTS USING MICROTRACE APPROACH

Metabolite Safety in Drug Development, 2016, p.243-260

2016

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INTEGRATED REACTIVE METABOLITE STRATEGIES

Metabolite Safety in Drug Development, 2016, p.111-139

2016

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MIST AND THE FUTURE

Metabolite Safety in Drug Development, 2016, p.305-322

2016

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THE VALUE OF METABOLITE IDENTIFICATION AND QUANTIFICATION IN CLINICAL STUDIES. SOME CASE STUDIES ENABLING EARLY ASSESSMENT OF SAFETY IN HUMANS

Metabolite Safety in Drug Development, 2016, p.275-291

2016

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IN SILICO MODELING OF METABOLITE KINETICS

Metabolite Safety in Drug Development, 2016, p.213-237

2016

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INTRODUCTION

Metabolite Safety in Drug Development, 2016, p.1-16

2016

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IN VITRO METHODS FOR EVALUATION OF DRUG METABOLISM

Metabolite Safety in Drug Development, 2016, p.87-110

2016

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UNDERSTANDING DRUG METABOLISM IN HUMANS

Metabolite Safety in Drug Development, 2016, p.141-176

2016

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DEALING WITH REALITY

Metabolite Safety in Drug Development, 2016, p.261-273

2016

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Metabolite safety in drug development

The cardiolipin–cytochrome c interaction and the mitochondrial regulation of apoptosis

Mapping Drug Distribution in Brain Tissue Using Liquid Extraction Surface Analysis Mass Spectrometry Imaging

Qualitative and Quantitative MALDI Imaging of the Positron Emission Tomography Ligands Raclopride (a D2 Dopamine Antagonist) and SCH 23390 (a D1 Dopamine Antagonist) in Rat Brain Tissue Sections Using a Solvent-Free Dry Matrix Application Method

Exemplifying the Screening Power of Mass Spectrometry Imaging over Label-Based Technologies for Simultaneous Monitoring of Drug and Metabolite Distributions in Tissue Sections

Cardiolipin Is Not Required for Bax-mediated Cytochrome c Release from Yeast Mitochondria

Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation

Pragmatic Approaches to Determine the Exposures of Drug Metabolites in Preclinical and Clinical Subjects in the MIST Evaluation of the Clinical Development Phase

The significance of ambient-temperature on pharmaceutical and endogenous compound abundance and distribution in tissues sections when analyzed by matrix-assisted laser desorption/ionization mass spectrometry imaging

Identification of a Reactive Metabolite of Terbinafine: Insights into Terbinafine-Induced Hepatotoxicity

Bioactivation of Estrone and Its Catechol Metabolites to Quinoid−Glutathione Conjugates in Rat Liver Microsomes

The Influence of the p-Alkyl Substituent on the Isomerization of o-Quinones to p-Quinone Methides: Potential Bioactivation Mechanism for Catechols

INTRODUCTION TO CASE STUDIES

The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells

Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation: Imaging Mass Spectrometry: A User's Guide to a New Technique for Biological and Biomedical Research

“MIST” AND OTHER METABOLITE GUIDELINES IN THE CONTEXT OF INDUSTRIAL DRUG METABOLISM

A MASS BALANCE AND METABOLITE PROFILING STUDY OF SONIDEGIB IN HEALTHY MALE SUBJECTS USING MICROTRACE APPROACH

INTEGRATED REACTIVE METABOLITE STRATEGIES

MIST AND THE FUTURE

THE VALUE OF METABOLITE IDENTIFICATION AND QUANTIFICATION IN CLINICAL STUDIES. SOME CASE STUDIES ENABLING EARLY ASSESSMENT OF SAFETY IN HUMANS

IN SILICO MODELING OF METABOLITE KINETICS

INTRODUCTION

IN VITRO METHODS FOR EVALUATION OF DRUG METABOLISM

UNDERSTANDING DRUG METABOLISM IN HUMANS

DEALING WITH REALITY

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