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Discovery of N‑(4‑[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer

Journal of medicinal chemistry, 2019-03, Vol.62 (6), p.2974-2987

2019

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Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

Journal of medicinal chemistry, 2012-10, Vol.55 (20), p.8685-8699

2012

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Discovery of a Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitor for the Potential Treatment of Schizophrenia

Journal of medicinal chemistry, 2014-05, Vol.57 (10), p.4196-4212

2014

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Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors as Candidates for Positron Emission Tomography Imaging

Journal of medicinal chemistry, 2011-08, Vol.54 (16), p.5820-5835

2011

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Discovery of New Tetracyclic Tetrahydrofuran Derivatives as Potential Broad-Spectrum Psychotropic Agents

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1709-1712

2005

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Automated open-access liquid chromatography high resolution mass spectrometry to support drug discovery projects

Journal of pharmaceutical and biomedical analysis, 2020-01, Vol.178, p.112908-112908, Article 112908

2020

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Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a, 8-tetrahydrodibenzo[c, f]isoxazolo[2,3-a]azepine derivatives: A novel series of 5-HT2A/2C receptor antagonists. Part 1

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (2), p.243-248

2002

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Correction to Discovery of N‑(4‑[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer

Journal of medicinal chemistry, 2020-02, Vol.63 (4), p.1775-1775

2020

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Synthesis of 2-N,N-Dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo-[b,f]furo[2,3-d]oxepin Derivatives as Potential Anxiolytic Agents

Chemical and Pharmaceutical Bulletin, 2004, Vol.52(2), pp.262-265

2004

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Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (4), p.653-658

2002

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Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a, 8-tetrahydrodibenzo[c, f]isoxazolo[2,3-a]azepine derivatives: A novel series of 5-HT2A/2C receptor antagonists. Part 2

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (2), p.249-253

2002

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Novel Approach for Chemotype Hopping Based on Annotated Databases of Chemically Feasible Fragments and a Prospective Case Study: New Melanin Concentrating Hormone Antagonists

Journal of medicinal chemistry, 2009-04, Vol.52 (7), p.2076-2089

2009

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Tricyclic isoxazolines : Identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and α2-adrenoceptor antagonism

Bioorganic & medicinal chemistry, 2007-06, Vol.15 (11), p.3649-3660

2007

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Discovery of a New Series of Centrally Active Tricyclic Isoxazoles Combining Serotonin (5-HT) Reuptake Inhibition with α2-Adrenoceptor Blocking Activity

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.2054-2071

2005

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Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano [4,3-c]isoxazole derivatives displaying combined α2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities

Bioorganic & medicinal chemistry, 2006-07, Vol.14 (13), p.4361-4372

2006

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Synthesis of novel 3-substituted-2,3-dihydro-1,4-dioxino[2,3- b]pyridines as potential new scaffolds for drug discovery: selective introduction of substituents on the pyridine ring

Tetrahedron letters, 2003-12, Vol.44 (50), p.8983-8986

2003

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Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole derivatives displaying combined alpha2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities

Bioorganic & medicinal chemistry, 2006-07, Vol.14 (13), p.4361-4372

2006

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Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole derivatives displaying combined alpha sub(2)-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities

Bioorganic & medicinal chemistry, 2006-07, Vol.14 (13), p.4361-4372

2006

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Synthesis of 7-amino-3a,4-dihydro-3 H-[1]benzopyrano[4,3- c]isoxazole derivatives displaying combined α 2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities

Bioorganic & medicinal chemistry, 2006, Vol.14 (13), p.4361-4372

2006

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Synthesis and structure-activity relationship of 2-(aminoalkyl)-3,3a, 8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furan derivatives: a novel series of 5-HT2A/2C receptor antagonists

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (11), p.2765-2771

2004

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NMR investigations of protein–carbohydrate interactions: insights into the topology of the bound conformation of a lactose isomer and β-galactosyl xyloses to mistletoe lectin and galectin-1

Biochimica et biophysica acta, 2001-12, Vol.1568 (3), p.225-236

2001

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2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT2C antagonist with potential anxiolytic properties

Bioorganic & medicinal chemistry letters, 2002-12, Vol.12 (24), p.3573-3577

2002

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Discovery of N‑(4‑[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer

Discovery of 8‑Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3‑a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM)

Discovery of 3‑Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3‑a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

Discovery of a Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitor for the Potential Treatment of Schizophrenia

Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors as Candidates for Positron Emission Tomography Imaging

Discovery of New Tetracyclic Tetrahydrofuran Derivatives as Potential Broad-Spectrum Psychotropic Agents

Automated open-access liquid chromatography high resolution mass spectrometry to support drug discovery projects

Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a, 8-tetrahydrodibenzo[c, f]isoxazolo[2,3-a]azepine derivatives: A novel series of 5-HT2A/2C receptor antagonists. Part 1

Correction to Discovery of N‑(4‑[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer

Synthesis of 2-N,N-Dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo-[b,f]furo[2,3-d]oxepin Derivatives as Potential Anxiolytic Agents

Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors

Dihydrothiazolopyridone Derivatives as a Novel Family of Positive Allosteric Modulators of the Metabotropic Glutamate 5 (mGlu5) Receptor

Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a, 8-tetrahydrodibenzo[c, f]isoxazolo[2,3-a]azepine derivatives: A novel series of 5-HT2A/2C receptor antagonists. Part 2

Novel Approach for Chemotype Hopping Based on Annotated Databases of Chemically Feasible Fragments and a Prospective Case Study: New Melanin Concentrating Hormone Antagonists

Tricyclic isoxazolines : Identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and α2-adrenoceptor antagonism

Discovery of a New Series of Centrally Active Tricyclic Isoxazoles Combining Serotonin (5-HT) Reuptake Inhibition with α2-Adrenoceptor Blocking Activity

Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano [4,3-c]isoxazole derivatives displaying combined α2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities

Synthesis of novel 3-substituted-2,3-dihydro-1,4-dioxino[2,3- b]pyridines as potential new scaffolds for drug discovery: selective introduction of substituents on the pyridine ring

Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole derivatives displaying combined alpha2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities

Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole derivatives displaying combined alpha sub(2)-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities

Synthesis of 7-amino-3a,4-dihydro-3 H-[1]benzopyrano[4,3- c]isoxazole derivatives displaying combined α 2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities

Synthesis and structure-activity relationship of 2-(aminoalkyl)-3,3a, 8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furan derivatives: a novel series of 5-HT2A/2C receptor antagonists

NMR investigations of protein–carbohydrate interactions: insights into the topology of the bound conformation of a lactose isomer and β-galactosyl xyloses to mistletoe lectin and galectin-1

2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT2C antagonist with potential anxiolytic properties

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