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Early Postnatal Treatment with Valproate Induces Gad1 Promoter Remodeling in the Brain and Reduces Apnea Episodes in Mecp2 -Null Mice

International journal of molecular sciences, 2019-10, Vol.20 (20), p.5177

2019

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Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP/PS1 Transgenic Mouse Model

Frontiers in molecular neuroscience, 2021-11, Vol.14, p.782375-782375

2021

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Hypoxia-induced upregulation of angiogenic factors in immortalized human periodontal ligament fibroblasts

Journal of Oral Science, 2018, Vol.60(4), pp.519-525

2018

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Effect of hypoxia on the expression of CCAAT/enhancer-binding protein β and receptor activator of nuclear factor kappa-B ligand in periodontal ligament cells

Journal of Oral Science, 2018, Vol.60(4), pp.544-551

2018

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Morphine, Oxycodone, and Fentanyl Exhibit Different Analgesic Profiles in Mouse Pain Models

Journal of Pharmacological Sciences, 2009, Vol.111(1), pp.60-72

2009

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Neurotrophins facilitate neuronal differentiation of cultured neural stem cells via induction of mRNA expression of basic helix-loop-helix transcription factors Mash1 and Math1

Journal of neuroscience research, 2003-03, Vol.71 (5), p.648-658

2003

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Distinct Relations Among Plasma Concentrations Required for Different Pharmacological Effects in Oxycodone, Morphine, and Fentanyl

Journal of pain & palliative care pharmacotherapy, 2011-11, Vol.25 (4), p.318-334

2011

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Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction

European journal of medicinal chemistry, 2021-04, Vol.216, p.113270, Article 113270

2021

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Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β‑Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial

Journal of medicinal chemistry, 2021-02, Vol.64 (4), p.1873-1888

2021

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Structure-Based Design of Selective β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.5080-5095

2019

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Oxycodone-Induced Analgesic Effects in a Bone Cancer Pain Model in Mice

Oncology, 2008-01, Vol.74 (1), p.55-60

2008

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Growth arrest of PC12 cells by nerve growth factor is dependent on the phosphatidylinositol 3-kinase/Akt pathway via p75 neurotrophin receptor

Journal of neuroscience research, 2003-04, Vol.72 (2), p.211-217

2003

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Discovery of Extremely Selective Fused Pyridine-Derived β‑Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions

Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14165-14174

2021

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Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β‑Secretase (BACE1) Inhibitors over BACE2

Journal of medicinal chemistry, 2021-03, Vol.64 (6), p.3075-3085

2021

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Discovery of Potent and Centrally Active 6‑Substituted 5‑Fluoro-1,3-dihydro-oxazine β‑Secretase (BACE1) Inhibitors via Active Conformation Stabilization

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5525-5546

2018

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Rational Design of Novel 1,3-Oxazine Based β‑Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P‑gp Efflux Leading to Robust Aβ Reduction in the Brain

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5122-5137

2018

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Wonhyo's 元暁 View on the Concepts of Universal Principle 理 and Particular Phenomena 事

Journal of Indian and Buddhist Studies (Indogaku Bukkyogaku Kenkyu), 2011/12/20, Vol.60(1), pp.66-69

ITO, Hisanori

2011

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4-methylcatechol increases brain-derived neurotrophic factor content and mRNA expression in cultured brain cells and in rat brain in vivo

The Journal of pharmacology and experimental therapeutics, 1999-12, Vol.291 (3), p.1276

1999

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Discovery of an Extremely Potent Thiazine-Based β‑Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose

Journal of medicinal chemistry, 2019-10, Vol.62 (20), p.9331-9337

2019

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The Background of Fabao's Citation from the Laozi

Journal of Indian and Buddhist Studies (Indogaku Bukkyogaku Kenkyu), 2010/12/20, Vol.59(1), pp.247-250

ITO, Hisanori

2010

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Functional expression of BMP7 receptors in oral epithelial cells. Interleukin-17F production in response to BMP7

Journal of receptors and signal transduction, 2017-09, Vol.37 (5), p.515-521

2017

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PRECLINICAL MULTI-SPECIES PHARMACOKINETIC/PHARMACODYNAMIC ANALYSIS OF THE ORAL BACE INHIBITOR JNJ-54861911

Alzheimer's & dementia, 2017-07, Vol.13 (7), p.P266-P267

2017

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Rhodium-catalyzed conjugate addition of aryl- and alkenyl-stannanes to α,β-unsaturated carbonyl compounds

Tetrahedron, 2002, Vol.58 (1), p.91-97

2002

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Electrochemical behavior of aluminum-coated Nd–Fe–B alloy

Journal of alloys and compounds, 2006-02, Vol.408, p.1426-1428

2006

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Early Postnatal Treatment with Valproate Induces Gad1 Promoter Remodeling in the Brain and Reduces Apnea Episodes in Mecp2 -Null Mice

Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP/PS1 Transgenic Mouse Model

Hypoxia-induced upregulation of angiogenic factors in immortalized human periodontal ligament fibroblasts

Effect of hypoxia on the expression of CCAAT/enhancer-binding protein β and receptor activator of nuclear factor kappa-B ligand in periodontal ligament cells

Morphine, Oxycodone, and Fentanyl Exhibit Different Analgesic Profiles in Mouse Pain Models

Neurotrophins facilitate neuronal differentiation of cultured neural stem cells via induction of mRNA expression of basic helix-loop-helix transcription factors Mash1 and Math1

Distinct Relations Among Plasma Concentrations Required for Different Pharmacological Effects in Oxycodone, Morphine, and Fentanyl

Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction

Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β‑Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial

Structure-Based Design of Selective β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2

Oxycodone-Induced Analgesic Effects in a Bone Cancer Pain Model in Mice

Growth arrest of PC12 cells by nerve growth factor is dependent on the phosphatidylinositol 3-kinase/Akt pathway via p75 neurotrophin receptor

Discovery of Extremely Selective Fused Pyridine-Derived β‑Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions

Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β‑Secretase (BACE1) Inhibitors over BACE2

Discovery of Potent and Centrally Active 6‑Substituted 5‑Fluoro-1,3-dihydro-oxazine β‑Secretase (BACE1) Inhibitors via Active Conformation Stabilization

Rational Design of Novel 1,3-Oxazine Based β‑Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P‑gp Efflux Leading to Robust Aβ Reduction in the Brain

Wonhyo's 元暁 View on the Concepts of Universal Principle 理 and Particular Phenomena 事

4-methylcatechol increases brain-derived neurotrophic factor content and mRNA expression in cultured brain cells and in rat brain in vivo

Discovery of an Extremely Potent Thiazine-Based β‑Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose

The Background of Fabao's Citation from the Laozi

Trifluoromethyl Dihydrothiazine‐Based β‐Secretase (BACE1) Inhibitors with Robust Central β‐Amyloid Reduction and Minimal Covalent Binding Burden

Functional expression of BMP7 receptors in oral epithelial cells. Interleukin-17F production in response to BMP7

PRECLINICAL MULTI-SPECIES PHARMACOKINETIC/PHARMACODYNAMIC ANALYSIS OF THE ORAL BACE INHIBITOR JNJ-54861911

Rhodium-catalyzed conjugate addition of aryl- and alkenyl-stannanes to α,β-unsaturated carbonyl compounds

Electrochemical behavior of aluminum-coated Nd–Fe–B alloy

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