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A novel IkB kinase inhibitor attenuates ligature‐induced periodontal disease in mice

Journal of periodontal research, 2019-04, Vol.54 (2), p.164-173

2019

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Plasminogen activator inhibitor-1 is an independent prognostic factor of ovarian cancer and IMD-4482, a novel plasminogen activator inhibitor-1 inhibitor, inhibits ovarian cancer peritoneal dissemination

Oncotarget, 2017-10, Vol.8 (52), p.89887-89902

2017

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Efficient Method for High-Throughput Virtual Screening Based on Flexible Docking: Discovery of Novel Acetylcholinesterase Inhibitors

Journal of medicinal chemistry, 2004-09, Vol.47 (20), p.4818-4828

2004

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IMD-4690, a novel specific inhibitor for plasminogen activator inhibitor-1, reduces allergic airway remodeling in a mouse model of chronic asthma via regulating angiogenesis and remodeling-related mediators

PloS one, 2015-03, Vol.10 (3), p.e0121615-e0121615

2015

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Effectiveness of IκB kinase inhibitors in murine colitis-associated tumorigenesis

Journal of gastroenterology, 2009-09, Vol.44 (9), p.935-943

2009

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Effective handling of induced-fit motion in flexible docking

Proteins, structure, function, and bioinformatics, 2006-06, Vol.63 (4), p.878-891

2006

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Aldosterone-induced kidney injury is mediated by NFκB activation

Clinical and experimental nephrology, 2011-02, Vol.15 (1), p.41-49

2011

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An IκB kinase 2 inhibitor IMD‐0354 suppresses the survival of adult T‐cell leukemia cells

Cancer science, 2012-01, Vol.103 (1), p.100-106

2012

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Effects of specific chemical suppressors of plasminogen activator inhibitor-1 in cardiovascular diseases

Expert opinion on investigational drugs, 2011-02, Vol.20 (2), p.255-264

2011

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Prediction of Ligand Binding Affinity Using a Multiple-Conformations-Multiple-Protonation Scheme: Application to Estrogen Receptor α

Chemical and Pharmaceutical Bulletin, 2012/02/01, Vol.60(2), pp.183-194

2012

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The effects of pharmacologic plasminogen activator inhibitor-1 inhibition in acute and chronic rejection in murine cardiac allografts

Transplantation, 2011-01, Vol.91 (1), p.21-26

2011

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A Novel IKK Inhibitor Prevents Progression of Restenosis After Arterial Injury in Mice

International Heart Journal, 2012, Vol.53(2), pp.133-138

2012

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Activation of IκB Kinase β and NF-κB Is Essential for Helicobacter pylori-Induced Chronic Gastritis in Mongolian Gerbils

Infection and Immunity, 2008-02, Vol.76 (2), p.781-787

2008

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Effects of Pharmacological Suppression of Plasminogen Activator Inhibitor-1 in Myocardial Remodeling After Ischemia Reperfusion Injury

International Heart Journal, 2011, Vol.52(6), pp.388-392

2011

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The effects of pharmacological PAI-1 inhibition on thrombus formation and neointima formation after arterial injury

Expert opinion on therapeutic targets, 2008-07, Vol.12 (7), p.783-794

2008

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Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4‑(1-Pyrrolidinyl)piperidine Structure

Journal of medicinal chemistry, 2023-08, Vol.66 (16), p.11428-11446

2023

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Pathophysiological roles of nuclear factor kappaB (NF-kB) in pulmonary arterial hypertension: effects of synthetic selective NF-kB inhibitor IMD-0354

Cardiovascular research, 2013-07, Vol.99 (1), p.35-43

2013

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A specific inhibitor of plasminogen activator inhibitor-1 suppresses rat autoimmune myocarditis

Expert opinion on therapeutic targets, 2008-11, Vol.12 (11), p.1313-1320

2008

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Discovery and structure-activity relationship study of 2-piperazinyl-benzothiazole derivatives as potent and selective PPARδ agonists

Bioorganic & medicinal chemistry, 2023-03, Vol.82, p.117215-117215, Article 117215

2023

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Starting Point to Molecular Design: Efficient Automated 3D Model Builder Key3D

Chemical and Pharmaceutical Bulletin, 2006, Vol.54(12), pp.1680-1685

2006

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Discovery and structure-based design of a new series of potent and selective PPARδ agonists utilizing a virtual screening method

Bioorganic & medicinal chemistry letters, 2022-03, Vol.59, p.128567-128567, Article 128567

2022

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Discovery of Novel Aldose Reductase Inhibitors Using a Protein Structure-Based Approach: 3D-Database Search Followed by Design and Synthesis

Journal of medicinal chemistry, 2001-05, Vol.44 (11), p.1718-1728

2001

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Synthesis, Conformation, and Biological Activity of Teleocidin Mimics, Benzolactams. A Clarification of the Conformational Flexibility Problem in Structure−Activity Studies of Teleocidins

Journal of the American Chemical Society, 1996-02, Vol.118 (8), p.1841-1855

1996

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Attenuation of experimental autoimmune uveoretinitis in mice by IKKβ inhibitor IMD-0354

Biochemical and biophysical research communications, 2020-05, Vol.525 (3), p.589-594

2020

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Topical Application with a New NF-κB Inhibitor Improves Atopic Dermatitis in NC/NgaTnd Mice

Journal of investigative dermatology, 2007-04, Vol.127 (4), p.855-863

2007

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A novel IkB kinase inhibitor attenuates ligature‐induced periodontal disease in mice

Plasminogen activator inhibitor-1 is an independent prognostic factor of ovarian cancer and IMD-4482, a novel plasminogen activator inhibitor-1 inhibitor, inhibits ovarian cancer peritoneal dissemination

Efficient Method for High-Throughput Virtual Screening Based on Flexible Docking: Discovery of Novel Acetylcholinesterase Inhibitors

IMD-4690, a novel specific inhibitor for plasminogen activator inhibitor-1, reduces allergic airway remodeling in a mouse model of chronic asthma via regulating angiogenesis and remodeling-related mediators

Effectiveness of IκB kinase inhibitors in murine colitis-associated tumorigenesis

Effective handling of induced-fit motion in flexible docking

Aldosterone-induced kidney injury is mediated by NFκB activation

An IκB kinase 2 inhibitor IMD‐0354 suppresses the survival of adult T‐cell leukemia cells

Effects of specific chemical suppressors of plasminogen activator inhibitor-1 in cardiovascular diseases

Prediction of Ligand Binding Affinity Using a Multiple-Conformations-Multiple-Protonation Scheme: Application to Estrogen Receptor α

The effects of pharmacologic plasminogen activator inhibitor-1 inhibition in acute and chronic rejection in murine cardiac allografts

A Novel IKK Inhibitor Prevents Progression of Restenosis After Arterial Injury in Mice

Activation of IκB Kinase β and NF-κB Is Essential for Helicobacter pylori-Induced Chronic Gastritis in Mongolian Gerbils

Effects of Pharmacological Suppression of Plasminogen Activator Inhibitor-1 in Myocardial Remodeling After Ischemia Reperfusion Injury

The effects of pharmacological PAI-1 inhibition on thrombus formation and neointima formation after arterial injury

Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4‑(1-Pyrrolidinyl)piperidine Structure

Pathophysiological roles of nuclear factor kappaB (NF-kB) in pulmonary arterial hypertension: effects of synthetic selective NF-kB inhibitor IMD-0354

A specific inhibitor of plasminogen activator inhibitor-1 suppresses rat autoimmune myocarditis

Discovery and structure-activity relationship study of 2-piperazinyl-benzothiazole derivatives as potent and selective PPARδ agonists

Starting Point to Molecular Design: Efficient Automated 3D Model Builder Key3D

Discovery and structure-based design of a new series of potent and selective PPARδ agonists utilizing a virtual screening method

Discovery of Novel Aldose Reductase Inhibitors Using a Protein Structure-Based Approach: 3D-Database Search Followed by Design and Synthesis

Synthesis, Conformation, and Biological Activity of Teleocidin Mimics, Benzolactams. A Clarification of the Conformational Flexibility Problem in Structure−Activity Studies of Teleocidins

Attenuation of experimental autoimmune uveoretinitis in mice by IKKβ inhibitor IMD-0354

Topical Application with a New NF-κB Inhibitor Improves Atopic Dermatitis in NC/NgaTnd Mice

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