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Cardiomyocyte-Specific Loss of Neurofibromin Promotes Cardiac Hypertrophy and Dysfunction

Circulation research, 2009-07, Vol.105 (3), p.304-311

2009

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PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex Vivo Thrombus Formation

Arteriosclerosis, thrombosis, and vascular biology, 2018-02, Vol.38 (2), p.448-456

2018

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Jun is required in Isl1-expressing progenitor cells for cardiovascular development

PloS one, 2013-02, Vol.8 (2), p.e57032-e57032

2013

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Safety, Tolerability, and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder for Pulmonary Hypertension: A Phase 1, Randomized, Double-Blind, Single- and Multiple-Dose Study

Advances in therapy, 2022-11, Vol.39 (11), p.5144-5157

2022

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Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI

Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (52), p.22305-22310

2009

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NF1 regulates a ras-dependent vascular smooth muscle proliferative injury response

Circulation (New York, N.Y.), 2007-11, Vol.116 (19), p.2148-2156

2007

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Nf1 has an essential role in endothelial cells

Nature genetics, 2003-01, Vol.33 (1), p.75-79

2003

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The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice

The Journal of clinical investigation, 2006-09, Vol.116 (9), p.2378-2384

2006

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Homeobox Protein Hop Functions in the Adult Cardiac Conduction System

Circulation research, 2005-04, Vol.96 (8), p.898-903

2005

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Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

Nature medicine, 2004-08, Vol.10 (8), p.849-857

2004

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Role of Homeodomain-Only Protein in the Cardiac Conduction System

Trends in cardiovascular medicine, 2006-08, Vol.16 (6), p.193-198

2006

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Coronary anatomy in congenitally corrected transposition of the great arteries

International journal of cardiology, 2002-12, Vol.86 (2), p.207-216

2002

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Right Aortic Arch and Coarctation: A Rare Association

Congenital heart disease, 2006-09, Vol.1 (5), p.217-223

2006

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MicroRNAs in cardiac neural crest are critical for cardiac outflow tract patterning

Developmental biology, 2009-07, Vol.331 (2), p.447-448

Ismat, Fraz A.

2009

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Abstract TMP91: Phase I Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the Oral Protease-activated Receptor-4 Antagonist BMS-986120

Stroke (1970), 2016-02, Vol.47 (suppl_1)

2016

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

Nature medicine, 2004-08, Vol.10 (8), p.849-857

2004

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Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction through activation of the fetal gene program

Developmental biology, 2008-07, Vol.319 (2), p.525-525

2008

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The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1^sup -/-^ mice

The Journal of clinical investigation, 2006-09, Vol.116 (9), p.2378

2006

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The neurofibromin GAP-related domain rescues endothelial but not neural crest development in [Nf1.sup.-/-] mice

The Journal of clinical investigation, 2006-09, Vol.116 (9), p.2378

2006

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Abstract 18771: Protease-Activated Receptor Type 4 (PAR-4) Antagonism With BMS-986120 Selectively Inhibits Human Thrombus Formation Under Conditions of High Shear Stress

Circulation (New York, N.Y.), 2016-11, Vol.134 (Suppl_1 Suppl 1), p.A18771-A18771

2016

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

Nature medicine, 2004-08, Vol.10 (8), p.849-857

2004

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Long-term Electrocardiographic Safety Monitoring in Clinical Drug Development: A Report from the Cardiac Safety Research Consortium

The American heart journal, 2017-05, Vol.187, p.156-169

2017

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Abstract WP263: Mutagenesis Studies Revealed Minimal Impact of Human A120T Variant of Protease-activated Receptor 4 on Receptor function or Pharmacological Response to a Potent and Selective Antagonist

Stroke (1970), 2016-02, Vol.47 (suppl_1)

2016

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Cardiomyocyte-Specific Loss of Neurofibromin Promotes Cardiac Hypertrophy and Dysfunction

PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex Vivo Thrombus Formation

Jun is required in Isl1-expressing progenitor cells for cardiovascular development

Safety, Tolerability, and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder for Pulmonary Hypertension: A Phase 1, Randomized, Double-Blind, Single- and Multiple-Dose Study

Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI

NF1 regulates a ras-dependent vascular smooth muscle proliferative injury response

Nf1 has an essential role in endothelial cells

The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice

Homeobox Protein Hop Functions in the Adult Cardiac Conduction System

Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

Role of Homeodomain-Only Protein in the Cardiac Conduction System

Coronary anatomy in congenitally corrected transposition of the great arteries

Right Aortic Arch and Coarctation: A Rare Association

MicroRNAs in cardiac neural crest are critical for cardiac outflow tract patterning

Abstract TMP91: Phase I Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the Oral Protease-activated Receptor-4 Antagonist BMS-986120

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction through activation of the fetal gene program

The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1^sup -/-^ mice

The neurofibromin GAP-related domain rescues endothelial but not neural crest development in [Nf1.sup.-/-] mice

Abstract 18771: Protease-Activated Receptor Type 4 (PAR-4) Antagonism With BMS-986120 Selectively Inhibits Human Thrombus Formation Under Conditions of High Shear Stress

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

Long-term Electrocardiographic Safety Monitoring in Clinical Drug Development: A Report from the Cardiac Safety Research Consortium

Abstract WP263: Mutagenesis Studies Revealed Minimal Impact of Human A120T Variant of Protease-activated Receptor 4 on Receptor function or Pharmacological Response to a Potent and Selective Antagonist

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