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PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex Vivo Thrombus Formation

Arteriosclerosis, thrombosis, and vascular biology, 2018-02, Vol.38 (2), p.448

2018

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Safety, Tolerability, and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder for Pulmonary Hypertension: A Phase 1, Randomized, Double-Blind, Single- and Multiple-Dose Study

Advances in therapy, 2022-11, Vol.39 (11), p.5144-5157

2022

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Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

Nature medicine, 2004-08, Vol.10 (8), p.849-857

2004

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Jun is required in Isl1-expressing progenitor cells for cardiovascular development

PloS one, 2013-02, Vol.8 (2), p.e57032-e57032

2013

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Cardiomyocyte-Specific Loss of Neurofibromin Promotes Cardiac Hypertrophy and Dysfunction

Circulation research, 2009-07, Vol.105 (3), p.304-311

2009

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NF1 regulates a ras-dependent vascular smooth muscle proliferative injury response

Circulation (New York, N.Y.), 2007-11, Vol.116 (19), p.2148-2156

2007

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Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI

Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (52), p.22305-22310

2009

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Nf1 has an essential role in endothelial cells

Nature genetics, 2003-01, Vol.33 (1), p.75-79

2003

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The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice

The Journal of clinical investigation, 2006-09, Vol.116 (9), p.2378-2384

2006

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Homeobox Protein Hop Functions in the Adult Cardiac Conduction System

Circulation research, 2005-04, Vol.96 (8), p.898-903

2005

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Role of Homeodomain-Only Protein in the Cardiac Conduction System

Trends in cardiovascular medicine, 2006-08, Vol.16 (6), p.193-198

2006

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Coronary anatomy in congenitally corrected transposition of the great arteries

International journal of cardiology, 2002-12, Vol.86 (2), p.207-216

2002

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Right Aortic Arch and Coarctation: A Rare Association

Congenital heart disease, 2006-09, Vol.1 (5), p.217-223

2006

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MicroRNAs in cardiac neural crest are critical for cardiac outflow tract patterning

Developmental biology, 2009-07, Vol.331 (2), p.447-448

Ismat, Fraz A.

2009

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Abstract TMP91: Phase I Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the Oral Protease-activated Receptor-4 Antagonist BMS-986120

Stroke (1970), 2016-02, Vol.47 (suppl_1)

2016

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

Nature medicine, 2004-08, Vol.10 (8), p.849-857

2004

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Long-term Electrocardiographic Safety Monitoring in Clinical Drug Development: A Report from the Cardiac Safety Research Consortium

The American heart journal, 2017-05, Vol.187, p.156-169

2017

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Abstract WP263: Mutagenesis Studies Revealed Minimal Impact of Human A120T Variant of Protease-activated Receptor 4 on Receptor function or Pharmacological Response to a Potent and Selective Antagonist

Stroke (1970), 2016-02, Vol.47 (suppl_1)

2016

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Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction through activation of the fetal gene program

Developmental biology, 2008-07, Vol.319 (2), p.525-525

2008

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The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1^sup -/-^ mice

The Journal of clinical investigation, 2006-09, Vol.116 (9), p.2378

2006

Volltextzugriff (PDF)

The neurofibromin GAP-related domain rescues endothelial but not neural crest development in [Nf1.sup.-/-] mice

The Journal of clinical investigation, 2006-09, Vol.116 (9), p.2378

2006

Volltextzugriff (PDF)

Abstract 18771: Protease-Activated Receptor Type 4 (PAR-4) Antagonism With BMS-986120 Selectively Inhibits Human Thrombus Formation Under Conditions of High Shear Stress

Circulation (New York, N.Y.), 2016-11, Vol.134 (Suppl_1 Suppl 1), p.A18771-A18771

2016

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

Nature medicine, 2004-08, Vol.10 (8), p.849-857

2004

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PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex Vivo Thrombus Formation

Safety, Tolerability, and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder for Pulmonary Hypertension: A Phase 1, Randomized, Double-Blind, Single- and Multiple-Dose Study

Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

Jun is required in Isl1-expressing progenitor cells for cardiovascular development

Cardiomyocyte-Specific Loss of Neurofibromin Promotes Cardiac Hypertrophy and Dysfunction

NF1 regulates a ras-dependent vascular smooth muscle proliferative injury response

Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI

Nf1 has an essential role in endothelial cells

The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice

Homeobox Protein Hop Functions in the Adult Cardiac Conduction System

Role of Homeodomain-Only Protein in the Cardiac Conduction System

Coronary anatomy in congenitally corrected transposition of the great arteries

Right Aortic Arch and Coarctation: A Rare Association

MicroRNAs in cardiac neural crest are critical for cardiac outflow tract patterning

Abstract TMP91: Phase I Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the Oral Protease-activated Receptor-4 Antagonist BMS-986120

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

Long-term Electrocardiographic Safety Monitoring in Clinical Drug Development: A Report from the Cardiac Safety Research Consortium

Abstract WP263: Mutagenesis Studies Revealed Minimal Impact of Human A120T Variant of Protease-activated Receptor 4 on Receptor function or Pharmacological Response to a Potent and Selective Antagonist

Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction through activation of the fetal gene program

The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1^sup -/-^ mice

The neurofibromin GAP-related domain rescues endothelial but not neural crest development in [Nf1.sup.-/-] mice

Abstract 18771: Protease-Activated Receptor Type 4 (PAR-4) Antagonism With BMS-986120 Selectively Inhibits Human Thrombus Formation Under Conditions of High Shear Stress

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

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