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Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite

Drug metabolism and disposition, 2010-01, Vol.38 (1), p.92-99

2010

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Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment

European journal of clinical pharmacology, 2022-01, Vol.78 (1), p.65-73

2022

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Correction to: Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment

European journal of clinical pharmacology, 2022, Vol.78 (1), p.75-75

2022

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Effects of itraconazole and rifampicin on the single‐dose pharmacokinetics of the nonsteroidal mineralocorticoid receptor blocker esaxerenone in healthy Japanese subjects

British journal of clinical pharmacology, 2020-10, Vol.86 (10), p.2070-2079

2020

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Critical Impact of Drug-Drug Interactions via Intestinal CYP3A in the Risk Assessment of Weak Perpetrators Using Physiologically Based Pharmacokinetic Models

Drug metabolism and disposition, 2020-04, Vol.48 (4), p.288-296

2020

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A phase I study of pexidartinib, a colony-stimulating factor 1 receptor inhibitor, in Asian patients with advanced solid tumors

Investigational new drugs, 2020-02, Vol.38 (1), p.99-110

2020

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Modanifil activates the histaminergic system through the orexinergic neurons

Neuroscience letters, 2010-10, Vol.483 (3), p.193-196

2010

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Model‐based assessments of CYP3A‐mediated drug‐drug interaction risk of milademetan

Clinical and translational science, 2021-11, Vol.14 (6), p.2220-2230

2021

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Absolute Bioavailability of Esaxerenone and Food Effects on its Pharmacokinetics After a Single Oral Dose in Healthy Japanese Subjects: An Open-Label Crossover Study

Advances in therapy, 2019-07, Vol.36 (7), p.1618-1627

2019

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Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects

BMC pharmacology & toxicology, 2020-07, Vol.21 (1), p.1-10, Article 55

2020

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Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition

Drug metabolism and pharmacokinetics, 2020-02, Vol.35 (1), p.45-55

2020

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Language-specific and universal influences in children’s syntactic packaging of Manner and Path: A comparison of English, Japanese, and Turkish

Cognition, 2007, Vol.102 (1), p.16-48

2007

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Development of Cross-Linguistic Variation in Speech and Gesture: Motion Events in English and Turkish

Developmental psychology, 2008-07, Vol.44 (4), p.1040-1054

2008

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In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

Xenobiotica, 2019-08, Vol.49 (8), p.961-969

2019

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Efficacy and safety of mirikizumab as induction and maintenance therapy for Japanese patients with moderately to severely active ulcerative colitis: a subgroup analysis of the global phase 3 LUCENT-1 and LUCENT-2 studies

Intestinal research, 2024-04, Vol.22 (2), p.172-185

2024

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Possible involvement of serotonin 5-HT2 receptor in the regulation of feeding behavior through the histaminergic system

Neuropharmacology, 2011-07, Vol.61 (1), p.228-233

2011

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Human Carboxymethylenebutenolidase as a Bioactivating Hydrolase of Olmesartan Medoxomil in Liver and Intestine

The Journal of biological chemistry, 2010-04, Vol.285 (16), p.11892-11902

2010

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Paraoxonase 1 as a major bioactivating hydrolase for olmesartan medoxomil in human blood circulation: molecular identification and contribution to plasma metabolism

Drug metabolism and disposition, 2012-02, Vol.40 (2), p.374-380

2012

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Integrative role of the histaminergic system in feeding and taste perception

Frontiers in systems neuroscience, 2012-01, Vol.6, p.44

2012

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High dopamine turnover in the brains of Sandy mice

Neuroscience letters, 2007-06, Vol.421 (1), p.47-51

2007

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Interindividual variability of carboxymethylenebutenolidase homolog, a novel olmesartan medoxomil hydrolase, in the human liver and intestine

Drug metabolism and disposition, 2013-05, Vol.41 (5), p.1156-1162

2013

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The effect of hardness of food on amygdalar histamine release in rats

Brain research, 2010-02, Vol.1313, p.97-102

2010

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Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro

Drug metabolism and disposition, 1999-07, Vol.27 (7), p.763

1999

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Discovery of R-142086 as a Factor Xa (FXa) Inhibitor: Syntheses and Structure–Activity Relationships of Cinnamyl Derivatives

Chemical and Pharmaceutical Bulletin, 2009/01/01, Vol.57(1), pp.22-33

2009

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Drug-Drug Interaction Risk Assessment of Esaxerenone as a Perpetrator by In Vitro Studies and Static and Physiologically Based Pharmacokinetic Models

Drug metabolism and disposition, 2020-09, Vol.48 (9), p.769-777

2020

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Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite

Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment

Correction to: Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment

Effects of itraconazole and rifampicin on the single‐dose pharmacokinetics of the nonsteroidal mineralocorticoid receptor blocker esaxerenone in healthy Japanese subjects

Critical Impact of Drug-Drug Interactions via Intestinal CYP3A in the Risk Assessment of Weak Perpetrators Using Physiologically Based Pharmacokinetic Models

A phase I study of pexidartinib, a colony-stimulating factor 1 receptor inhibitor, in Asian patients with advanced solid tumors

Modanifil activates the histaminergic system through the orexinergic neurons

Model‐based assessments of CYP3A‐mediated drug‐drug interaction risk of milademetan

Absolute Bioavailability of Esaxerenone and Food Effects on its Pharmacokinetics After a Single Oral Dose in Healthy Japanese Subjects: An Open-Label Crossover Study

Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects

Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition

Language-specific and universal influences in children’s syntactic packaging of Manner and Path: A comparison of English, Japanese, and Turkish

Development of Cross-Linguistic Variation in Speech and Gesture: Motion Events in English and Turkish

In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

Efficacy and safety of mirikizumab as induction and maintenance therapy for Japanese patients with moderately to severely active ulcerative colitis: a subgroup analysis of the global phase 3 LUCENT-1 and LUCENT-2 studies

Possible involvement of serotonin 5-HT2 receptor in the regulation of feeding behavior through the histaminergic system

Human Carboxymethylenebutenolidase as a Bioactivating Hydrolase of Olmesartan Medoxomil in Liver and Intestine

Paraoxonase 1 as a major bioactivating hydrolase for olmesartan medoxomil in human blood circulation: molecular identification and contribution to plasma metabolism

Integrative role of the histaminergic system in feeding and taste perception

High dopamine turnover in the brains of Sandy mice

Interindividual variability of carboxymethylenebutenolidase homolog, a novel olmesartan medoxomil hydrolase, in the human liver and intestine

The effect of hardness of food on amygdalar histamine release in rats

Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro

Discovery of R-142086 as a Factor Xa (FXa) Inhibitor: Syntheses and Structure–Activity Relationships of Cinnamyl Derivatives

Drug-Drug Interaction Risk Assessment of Esaxerenone as a Perpetrator by In Vitro Studies and Static and Physiologically Based Pharmacokinetic Models

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