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Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo

Molecular pharmacology, 2014-03, Vol.85 (3), p.429-440

2014

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Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (9), p.3689-3694

2011

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A novel Toll-like receptor 7/8–specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus

European journal of pharmacology, 2023-10, Vol.957, p.175962-175962, Article 175962

2023

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Synthetic Toll-Like Receptor 4 Agonist Enhances Vaccine Efficacy in an Experimental Model of Toxic Shock Syndrome

Clinical and Vaccine Immunology, 2007-11, Vol.14 (11), p.1499-1504

2007

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The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

The Journal of biological chemistry, 2001-03, Vol.276 (13), p.10229-10233

2001

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Novel synthetic LPS receptor agonists boost systemic and mucosal antibody responses in mice

Vaccine, 2003-02, Vol.21 (9), p.961-970

2003

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E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant

Expert review of vaccines, 2007-10, Vol.6 (5), p.773-784

2007

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A novel class of endotoxin receptor agonists with simplified structure, toll-like receptor 4-dependent immunostimulatory action, and adjuvant activity

The Journal of pharmacology and experimental therapeutics, 2002-02, Vol.300 (2), p.655-661

2002

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Assessment of the translational value of mouse lupus models using clinically relevant biomarkers

Translational research : the journal of laboratory and clinical medicine, 2014-06, Vol.163 (6), p.515-532

2014

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Effective antibody therapy induces host-protective antitumor immunity that is augmented by TLR4 agonist treatment

Cancer Immunology, Immunotherapy, 2012-01, Vol.61 (1), p.49-61

2012

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Abstract LB-324: A toll-like receptor 4 agonist enhances the efficacy of trastuzumab therapy and promotes adaptive immunity and long-term protection against a human ErbB-2 (HER2)-transfected syngeneic tumor in a human HER2 transgenic mouse model

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.LB-324-LB-324

2010

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Genetic control of resistance to 3-methylcholanthrene-induced T-cell lymphoma in mice

Cancer research (Chicago, Ill.), 1989-03, Vol.49 (5), p.1214-1219

1989

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Modulators of Toll-Like Receptor (TLR) Signaling

Annual Reports in Medicinal Chemistry, 2010, Vol.45, p.191-207

2010

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IgG subtype is correlated with efficiency of passive protection and effector function of anti-herpes simplex virus glycoprotein D monoclonal antibodies

The Journal of infectious diseases, 1995-10, Vol.172 (4), p.1108-1111

1995

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Combined systemic and mucosal immunization with microsphere-encapsulated inactivated simian immunodeficiency virus elicits serum, vaginal, and tracheal antibody responses in female rhesus macaques

AIDS research and human retroviruses, 1999-08, Vol.15 (12), p.1121-1136

1999

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Induction of mucosal antibody responses by microsphere-encapsulated formalin-inactivated simian immunodeficiency virus in a male urethral challenge model

Vaccine, 1999-07, Vol.17 (22), p.2817-2825

1999

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Characterization of recombinant polioviruses expressing regions of rotavirus VP4, hepatitis B surface antigen, and herpes simplex virus type 2 glycoprotein D

Journal of Virology, 1995-08, Vol.69 (8), p.5132-5137

1995

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Analysis by limiting dilution of interleukin 2‐producing T cells in murine ontogeny

European journal of immunology, 1983, Vol.13 (11), p.936-942

1983

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Genetically determined resistance to 3-methylcholanthrene-induced lymphoma is expressed at the level of bone marrow-derived cells

The Journal of experimental medicine, 1987-08, Vol.166 (2), p.565-570

1987

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Effects of in Vivo Depletion of Immunocyte Populations on Herpes Simplex Virus Glycoprotein D Vaccine-Induced Resistance to HSV2 Challenge

Viral immunology, 1992, Vol.5 (2), p.151-161

1992

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Ontogeny of T-cell function: Alloreactivity appears earlier than reactivity against hapten-modified self and interleukin-2 production

Clinical immunology and immunopathology, 1982-05, Vol.23 (2), p.202-214

1982

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NC CELLS DO NOT EXPRESS NK-ASSOCIATED CELL SURFACE ANTIGENS AND ARE NOT CULTURE ACTIVATED NK CELLS

NK Cells and Other Natural Effector Cells, 1982, p.187-192

1982

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First‐in‐Human Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E6742, a Dual Antagonist of Toll‐like Receptors 7 and 8, in Healthy Volunteers

Clinical pharmacology in drug development, 2023-04, Vol.12 (4), p.363-375

2023

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Characterization of sepsis pathogenesis using molecular biomarkers and drug treatments in the mouse CLP model (56.6)

The Journal of immunology (1950), 2011-04, Vol.186 (1_Supplement), p.56-56.6

2011

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Safety, pharmacokinetics, and pharmacodynamics in first-in-human study of a novel compound E6742, a Toll-like receptor 7 and 8 antagonist

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2018, Vol.WCP2018, p.PO1-11-13

2018

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Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo

Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria

A novel Toll-like receptor 7/8–specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus

Synthetic Toll-Like Receptor 4 Agonist Enhances Vaccine Efficacy in an Experimental Model of Toxic Shock Syndrome

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

Novel synthetic LPS receptor agonists boost systemic and mucosal antibody responses in mice

E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant

A novel class of endotoxin receptor agonists with simplified structure, toll-like receptor 4-dependent immunostimulatory action, and adjuvant activity

Assessment of the translational value of mouse lupus models using clinically relevant biomarkers

Effective antibody therapy induces host-protective antitumor immunity that is augmented by TLR4 agonist treatment

Abstract LB-324: A toll-like receptor 4 agonist enhances the efficacy of trastuzumab therapy and promotes adaptive immunity and long-term protection against a human ErbB-2 (HER2)-transfected syngeneic tumor in a human HER2 transgenic mouse model

Genetic control of resistance to 3-methylcholanthrene-induced T-cell lymphoma in mice

Modulators of Toll-Like Receptor (TLR) Signaling

IgG subtype is correlated with efficiency of passive protection and effector function of anti-herpes simplex virus glycoprotein D monoclonal antibodies

Combined systemic and mucosal immunization with microsphere-encapsulated inactivated simian immunodeficiency virus elicits serum, vaginal, and tracheal antibody responses in female rhesus macaques

Induction of mucosal antibody responses by microsphere-encapsulated formalin-inactivated simian immunodeficiency virus in a male urethral challenge model

Characterization of recombinant polioviruses expressing regions of rotavirus VP4, hepatitis B surface antigen, and herpes simplex virus type 2 glycoprotein D

Analysis by limiting dilution of interleukin 2‐producing T cells in murine ontogeny

Genetically determined resistance to 3-methylcholanthrene-induced lymphoma is expressed at the level of bone marrow-derived cells

Effects of in Vivo Depletion of Immunocyte Populations on Herpes Simplex Virus Glycoprotein D Vaccine-Induced Resistance to HSV2 Challenge

Ontogeny of T-cell function: Alloreactivity appears earlier than reactivity against hapten-modified self and interleukin-2 production

NC CELLS DO NOT EXPRESS NK-ASSOCIATED CELL SURFACE ANTIGENS AND ARE NOT CULTURE ACTIVATED NK CELLS

First‐in‐Human Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E6742, a Dual Antagonist of Toll‐like Receptors 7 and 8, in Healthy Volunteers

Characterization of sepsis pathogenesis using molecular biomarkers and drug treatments in the mouse CLP model (56.6)

Safety, pharmacokinetics, and pharmacodynamics in first-in-human study of a novel compound E6742, a Toll-like receptor 7 and 8 antagonist

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