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Humanized mice in translational biomedical research

Nature Reviews: Immunology, 2007-02, Vol.7 (2), p.118-130

2007

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Modeling normal and malignant human hematopoiesis in vivo through newborn NSG xenotransplantation

International journal of hematology, 2013-12, Vol.98 (6), p.634-640

Ishikawa, Fumihiko

2013

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Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice

International journal of hematology, 2022-02, Vol.115 (2), p.198-207

2022

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Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia

Cancer cell, 2011-08, Vol.20 (2), p.246-259

2011

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Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML

Nature biotechnology, 2010-03, Vol.28 (3), p.275-280

2010

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Human cancer growth and therapy in immunodeficient mouse models

Cold Spring Harbor protocols, 2014-07, Vol.2014 (7), p.694

2014

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Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells

Science translational medicine, 2010-02, Vol.2 (17), p.17ra9

2010

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Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region

Nature biotechnology, 2007-11, Vol.25 (11), p.1315-1321

2007

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Deregulated Mucosal Immune Surveillance through Gut-Associated Regulatory T Cells and PD-1 + T Cells in Human Colorectal Cancer

The Journal of immunology (1950), 2018-05, Vol.200 (9), p.3291-3303

2018

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Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation

Blood, 2012-03, Vol.119 (12), p.2768-2777

2012

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Atypical SIFD with novel TRNT1 mutations: a case study on the pathogenesis of B-cell deficiency

International journal of hematology, 2019-04, Vol.109 (4), p.382-389

2019

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Identification of CD34’ and CD34− leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia

Blood, 2015-02, Vol.125 (6), p.967-980

2015

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Human Flt3 Is Expressed at the Hematopoietic Stem Cell and the Granulocyte/Macrophage Progenitor Stages to Maintain Cell Survival

The Journal of immunology (1950), 2008-06, Vol.180 (11), p.7358-7367

2008

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Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways

Science translational medicine, 2017-10, Vol.9 (413)

2017

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Clinical Impact of a Humanized CCR4 Antibody (Mogamulizumab) in 14 Patients with Aggressive Adult T-cell Leukemia-lymphoma Treated at a Single Institution During a Three-year Period (2012-2014)

Internal Medicine, 2016/06/01, Vol.55(11), pp.1439-1445

2016

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Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice

Life science alliance, 2019-04, Vol.2 (2), p.e201800195

2019

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The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways

Blood, 2007-11, Vol.110 (10), p.3591-3600

2007

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Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis

PloS one, 2011-11, Vol.6 (11), p.e27042-e27042

2011

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Detection of HTLV‐1 by means of HBZ gene in situ hybridization in formalin‐fixed and paraffin‐embedded tissues

Cancer science, 2011-07, Vol.102 (7), p.1432-1436

2011

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Hematopoietic origin of hepatic stellate cells in the adult liver

Blood, 2008-02, Vol.111 (4), p.2427-2435

2008

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Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model

EBioMedicine, 2019-03, Vol.41, p.584-596

2019

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Clinical Features and Treatment Outcomes of 81 Patients with Aggressive Type Adult T-cell Leukemia-lymphoma at a Single Institution over a 7-year Period (2006-2012)

Internal Medicine, 2015, Vol.54(12), pp.1489-1498

2015

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Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker⁺ cardiomyocytes in vivo

PloS one, 2013-05, Vol.8 (5), p.e62506-e62506

2013

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Guest editorial: Connecting multiple aspects of hematologic malignancies toward creation of new therapeutics

International journal of hematology, 2017-05, Vol.105 (5), p.547-548

Ishikawa, Fumihiko

2017

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The Impact of a Humanized CCR4 Antibody (Mogamulizumab) on Patients with Aggressive-Type Adult T-Cell Leukemia-Lymphoma Treated with Allogeneic Hematopoietic Stem Cell Transplantation

Journal of Clinical and Experimental Hematopathology, 2017, Vol.56(3), pp.135-144

2017

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Humanized mice in translational biomedical research

Modeling normal and malignant human hematopoiesis in vivo through newborn NSG xenotransplantation

Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice

Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia

Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML

Human cancer growth and therapy in immunodeficient mouse models

Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells

Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region

Deregulated Mucosal Immune Surveillance through Gut-Associated Regulatory T Cells and PD-1 + T Cells in Human Colorectal Cancer

Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation

Atypical SIFD with novel TRNT1 mutations: a case study on the pathogenesis of B-cell deficiency

Identification of CD34’ and CD34− leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia

Human Flt3 Is Expressed at the Hematopoietic Stem Cell and the Granulocyte/Macrophage Progenitor Stages to Maintain Cell Survival

Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways

Clinical Impact of a Humanized CCR4 Antibody (Mogamulizumab) in 14 Patients with Aggressive Adult T-cell Leukemia-lymphoma Treated at a Single Institution During a Three-year Period (2012-2014)

Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice

The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways

Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis

Detection of HTLV‐1 by means of HBZ gene in situ hybridization in formalin‐fixed and paraffin‐embedded tissues

Hematopoietic origin of hepatic stellate cells in the adult liver

Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model

Clinical Features and Treatment Outcomes of 81 Patients with Aggressive Type Adult T-cell Leukemia-lymphoma at a Single Institution over a 7-year Period (2006-2012)

Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker⁺ cardiomyocytes in vivo

Guest editorial: Connecting multiple aspects of hematologic malignancies toward creation of new therapeutics

The Impact of a Humanized CCR4 Antibody (Mogamulizumab) on Patients with Aggressive-Type Adult T-Cell Leukemia-Lymphoma Treated with Allogeneic Hematopoietic Stem Cell Transplantation

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