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The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

Genes & development, 2018-02, Vol.32 (3-4), p.309-320

2018

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Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Nature communications, 2017-07, Vol.8 (1), p.103-14, Article 103

2017

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Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Nature communications, 2019-06, Vol.10 (1), p.2527-2527, Article 2527

2019

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Identification of 2‑Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay

Biochemistry (Easton), 2023-07, Vol.62 (14), p.2147-2160

2023

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The contribution of small-scale, privately owned tropical aquaculture to food security and dietary diversity in Bolivia

Food security, 2021-02, Vol.13 (1), p.199-218

2021

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Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists

The Journal of biological chemistry, 2022-11, Vol.298 (11), p.102539, Article 102539

2022

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Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer

Molecular cancer therapeutics, 2022-06, Vol.21 (6), p.890-902

2022

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Abstract PS12-23: Development of H3B-6545, a first-in-class oral selective ER covalent antagonist (SERCA), for the treatment of ERaWT and ERaMUT breast cancer

Cancer research (Chicago, Ill.), 2021-02, Vol.81 (4_Supplement), p.PS12-23-PS12-23

2021

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Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3

ACS medicinal chemistry letters, 2021-01, Vol.12 (1), p.93-98

2021

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Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.DDT01-04-DDT01-04

2017

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Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα WT and ERα MUT Breast Cancer

Cancer discovery, 2018-09, Vol.8 (9), p.1176-1193

2018

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The Grammarian, the Skeptic, and the Nondualist: The Proof of Relation (Sambandhasiddhi) of Utpaladeva and the Place It Deserves in Contemporary Theories of Language and Cognition

MacCracken, Sean Kelley Irwin

2022

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Abstract LB-304: ATSP-9172, a novel Stapled Peptide inhibitor of HIF-dependent transcriptional activity with in vivo antitumor efficacy in a preclinical model of prostate cancer

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.LB-304-LB-304

2013

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Biochemical evidence for a conserved interaction between bacterial transferrin binding protein A and transferrin binding protein B

Microbial pathogenesis, 1998-02, Vol.24 (2), p.75-87

1998

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Preparation and analysis of isogenic mutants in the transferrin receptor protein genes, tbpA and tbpB, from Neisseria meningitidis

Molecular microbiology, 1993-06, Vol.8 (6), p.1125-1133

1993

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An Analysis Of Brand Equity Determinants: Gross Profit, Advertising, Research, And Development

Journal of business & economics research (Littleton, Colo.), 2011-02, Vol.5 (11)

2011

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Small-scale Aquaculture in the Bolivian Amazon: A contextually-based solution for positive social and economic outcomes

Sustainable Food Futures, 2017, p.89-102

1, 2017

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The role of the transferrin binding proteins of Neisseria meningitidis in iron acquisition from human transferrin

Irwin, Sean Wyndham

1994

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LEGACY LECTURE

The Canadian Architect, 2013-10, Vol.58 (10), p.38

Irwin, Sean

2013

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The home stretch

Maclean's (Toronto), 2008-01, Vol.121 (2), p.4

2008

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Interannual bumble bee abundance is driven by indirect climate effects on floral resource phenology

Ecology letters, 2017-12, Vol.20 (12), p.1507-1515

2017

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Bee phenology is predicted by climatic variation and functional traits

Ecology letters, 2020-11, Vol.23 (11), p.1589-1598

2020

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Loss of WDR23 proteostasis impacts mitochondrial homeostasis in the mouse brain

Cellular signalling, 2024-04, Vol.116, p.111061-111061, Article 111061

2024

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A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming

Nature genetics, 2009-05, Vol.41 (5), p.602-608

2009

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BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction

Journal of leukocyte biology, 2012-09, Vol.92 (3), p.593-603

2012

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The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Identification of 2‑Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay

The contribution of small-scale, privately owned tropical aquaculture to food security and dietary diversity in Bolivia

Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists

Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer

Abstract PS12-23: Development of H3B-6545, a first-in-class oral selective ER covalent antagonist (SERCA), for the treatment of ERaWT and ERaMUT breast cancer

Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3

Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer

Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα WT and ERα MUT Breast Cancer

The Grammarian, the Skeptic, and the Nondualist: The Proof of Relation (Sambandhasiddhi) of Utpaladeva and the Place It Deserves in Contemporary Theories of Language and Cognition

Abstract LB-304: ATSP-9172, a novel Stapled Peptide inhibitor of HIF-dependent transcriptional activity with in vivo antitumor efficacy in a preclinical model of prostate cancer

Biochemical evidence for a conserved interaction between bacterial transferrin binding protein A and transferrin binding protein B

Preparation and analysis of isogenic mutants in the transferrin receptor protein genes, tbpA and tbpB, from Neisseria meningitidis

An Analysis Of Brand Equity Determinants: Gross Profit, Advertising, Research, And Development

Small-scale Aquaculture in the Bolivian Amazon: A contextually-based solution for positive social and economic outcomes

The role of the transferrin binding proteins of Neisseria meningitidis in iron acquisition from human transferrin

LEGACY LECTURE

The home stretch

Interannual bumble bee abundance is driven by indirect climate effects on floral resource phenology

Bee phenology is predicted by climatic variation and functional traits

Loss of WDR23 proteostasis impacts mitochondrial homeostasis in the mouse brain

A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming

BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction

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