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Targeting WEE1 kinase as a p53-independent therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia

Cancer cell international, 2023-09, Vol.23 (1), p.1-202, Article 202

2023

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Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia

Nature genetics, 2009-09, Vol.41 (9), p.1006-1010

2009

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Towards an understanding of the biology and targeted treatment of paediatric relapsed acute lymphoblastic leukaemia

British journal of haematology, 2016-03, Vol.172 (5), p.655-666

Irving, Julie A. E.

2016

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Combination p53 activation and BCL-xL/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia

Leukemia, 2024-06, Vol.38 (6), p.1223-1235

2024

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SH2B3 inactivation through CN-LOH 12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain

Leukemia, 2019-08, Vol.33 (8), p.1881-1894

2019

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Glucocorticoid resistance in two key models of acute lymphoblastic leukemia occurs at the level of the glucocorticoid receptor

The FASEB journal, 2006-12, Vol.20 (14), p.2600-2602

2006

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The ability to cross the blood–cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

Blood, 2016-04, Vol.127 (16), p.1998-2006

2016

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Personalization of dexamethasone therapy in childhood acute lymphoblastic leukaemia

British journal of haematology, 2016-04, Vol.173 (1), p.13-24

2016

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MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells

Haematologica (Roma), 2009-01, Vol.94 (1), p.78-86

2009

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Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk

Blood, 2010-06, Vol.115 (22), p.4472-4477

2010

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DHFR and MSH3 co-amplification in childhood acute lymphoblastic leukaemia, in vitro and in vivo

Carcinogenesis (New York), 2007-06, Vol.28 (6), p.1341-1346

2007

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The influence of glucocorticoid receptor single nucleotide polymorphisms on outcome after haematopoietic stem cell transplantation

International journal of immunogenetics, 2018-10, Vol.45 (5), p.247-256

2018

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MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukemia

Blood, 2011-02, Vol.117 (5), p.1633-1640

2011

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Low Prevalence of the N363S Polymorphism of the Glucocorticoid Receptor in South Asians Living in the United Kingdom

The journal of clinical endocrinology and metabolism, 2004-01, Vol.89 (1), p.232-235

2004

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Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis

Cancer research (Chicago, Ill.), 2005-04, Vol.65 (8), p.3053-3058

2005

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Loss of heterozygosity and somatic mutations of the Glucocorticoid receptor gene are rarely found at relapse in pediatric acute lymphoblastic leukemia but may occur in a subpopulation early in the disease course

Cancer research (Chicago, Ill.), 2005-11, Vol.65 (21), p.9712-9718

2005

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Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM

Haematologica (Roma), 2019-09, Vol.104 (9), p.1804

2019

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A common intron 2 polymorphism of the glucocorticoid receptor gene is associated with insulin resistance in men

Clinical endocrinology (Oxford), 2008-06, Vol.68 (6), p.879-884

2008

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Detection of constitutional mismatch repair deficiency in children and adolescents with acute lymphoblastic leukemia

Leukemia & lymphoma, 2023-01, Vol.64 (1), p.217-220

2023

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Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia

Cancer research (Chicago, Ill.), 2008-08, Vol.68 (16), p.6803-6809

2008

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A polymorphism in the 3′ UTR of IRF4 linked to susceptibility and pathogenesis in chronic lymphocytic leukaemia and Hodgkin lymphoma has limited impact in multiple myeloma

British journal of haematology, 2010-08, Vol.150 (3), p.371-373

2010

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CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response

Haematologica (Roma), 2017-04, Vol.102 (4), p.736

2017

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Targeting WEE1 kinase as a p53-independent therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia

Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia

Towards an understanding of the biology and targeted treatment of paediatric relapsed acute lymphoblastic leukaemia

Combination p53 activation and BCL-xL/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia

Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia

SH2B3 inactivation through CN-LOH 12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain

Glucocorticoid resistance in two key models of acute lymphoblastic leukemia occurs at the level of the glucocorticoid receptor

Risk factors and outcomes in children with high-risk B-cell precursor and T-cell relapsed acute lymphoblastic leukaemia: combined analysis of ALLR3 and ALL-REZ BFM 2002 clinical trials

The ability to cross the blood–cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

Personalization of dexamethasone therapy in childhood acute lymphoblastic leukaemia

A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups

MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells

Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk

DHFR and MSH3 co-amplification in childhood acute lymphoblastic leukaemia, in vitro and in vivo

The influence of glucocorticoid receptor single nucleotide polymorphisms on outcome after haematopoietic stem cell transplantation

MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukemia

Low Prevalence of the N363S Polymorphism of the Glucocorticoid Receptor in South Asians Living in the United Kingdom

Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis

Loss of heterozygosity and somatic mutations of the Glucocorticoid receptor gene are rarely found at relapse in pediatric acute lymphoblastic leukemia but may occur in a subpopulation early in the disease course

Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM

A common intron 2 polymorphism of the glucocorticoid receptor gene is associated with insulin resistance in men

Detection of constitutional mismatch repair deficiency in children and adolescents with acute lymphoblastic leukemia

Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia

A polymorphism in the 3′ UTR of IRF4 linked to susceptibility and pathogenesis in chronic lymphocytic leukaemia and Hodgkin lymphoma has limited impact in multiple myeloma

CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response

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