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CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity

Neuropharmacology, 2007-02, Vol.52 (2), p.279-290

2007

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Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeys

The Journal of pharmacology and experimental therapeutics, 2007-10, Vol.323 (1), p.318-326

2007

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Combination of Rimonabant and Donepezil Prolongs Spatial Memory Duration

Neuropsychopharmacology (New York, N.Y.), 2007-08, Vol.32 (8), p.1805-1812

2007

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Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylamino-piperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist

Journal of medicinal chemistry, 2009-01, Vol.52 (2), p.234-237

2009

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Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist

Journal of medicinal chemistry, 2009-01, Vol.52 (2), p.234-237

2009

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Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a Novel, Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist for the Treatment of Obesity

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.2652-2655

2009

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Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents

ACS medicinal chemistry letters, 2012-05, Vol.3 (5), p.397-401

2012

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The cannabinoid CB1 receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task

European journal of pharmacology, 2008-08, Vol.590 (1-3), p.246-249

2008

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Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: Potent, orally-active 1,4-disubstituted imidazoles

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (18), p.5351-5354

2009

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The role of muscarinic receptor antagonism in antipsychotic-induced hippocampal acetylcholine release

European journal of pharmacology, 2005-01, Vol.506 (3), p.209-219

2005

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New bicyclic cannabinoid receptor-1 (CB 1-R) antagonists

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (3), p.731-736

2006

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Region-Specific Regulation of RGS4 (Regulator of G-Protein-Signaling Protein Type 4) in Brain by Stress and Glucocorticoids: In Vivo and In Vitro Studies

The Journal of neuroscience, 1999-05, Vol.19 (10), p.3674-3680

1999

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Increases in intracellular calcium via activation of an endogenous P2‐purinoceptor in cultured CHO‐K1 cells

British journal of pharmacology, 1993-12, Vol.110 (4), p.1305-1310

1993

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Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) receptor antagonist

BMC pharmacology, 2010-08, Vol.10 (1), p.9-9, Article 9

2010

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Glucocorticoid Regulation of Corticotropin-Releasing Factor1 Receptor Expression in Pituitary-Derived AtT-20 Cells

Molecular pharmacology, 1997-05, Vol.51 (5), p.794-799

1997

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Discovery of Two Clinical Histamine H 3 Receptor Antagonists: trans - N -Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans -3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]- N -(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

Journal of medicinal chemistry, 2011-11, Vol.54 (21), p.7602-7620

2011

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The cannabinoid CB(1) receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task

European journal of pharmacology, 2008-08, Vol.590 (1-3), p.246

2008

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The cannabinoid CB 1 receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task

European journal of pharmacology, 2008, Vol.590 (1), p.246-249

2008

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Role of Corticotropin‐Releasing Factor Receptor‐1 in Opiate Withdrawal

Journal of neurochemistry, 2000-01, Vol.74 (1), p.199-208

2000

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Agonist-induced changes in [Ca 2+] i in N1E-115 cells: differential effects of bradykinin and carbachol

European journal of pharmacology, 1992-06, Vol.226 (2), p.163-168

1992

Volltextzugriff (PDF)

Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2 H -pyrazolo[3,4- f ][1,4]oxazepin-8(5 H )-one (PF-514273), a Novel, Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist for the Treatment of Obesity

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.2652-2655

2009

Volltextzugriff (PDF)

Design of a Potent CB 1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents

ACS medicinal chemistry letters, 2012-05, Vol.3 (5), p.397-401

2012

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CP-809,101, a selective 5-HT 2C agonist, shows activity in animal models of antipsychotic activity

Neuropharmacology, 2007, Vol.52 (2), p.279-290

2007

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Differential regulation of corticotropin-releasing factor1 receptor expression by stress and agonist treatments in brain and cultured cells

Molecular pharmacology, 1996-11, Vol.50 (5), p.1103-1110

1996

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CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity

Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeys

Combination of Rimonabant and Donepezil Prolongs Spatial Memory Duration

Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylamino-piperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist

Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist

Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a Novel, Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist for the Treatment of Obesity

Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents

The cannabinoid CB1 receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task

Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: Potent, orally-active 1,4-disubstituted imidazoles

The role of muscarinic receptor antagonism in antipsychotic-induced hippocampal acetylcholine release

New bicyclic cannabinoid receptor-1 (CB 1-R) antagonists

Region-Specific Regulation of RGS4 (Regulator of G-Protein-Signaling Protein Type 4) in Brain by Stress and Glucocorticoids: In Vivo and In Vitro Studies

Increases in intracellular calcium via activation of an endogenous P2‐purinoceptor in cultured CHO‐K1 cells

Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) receptor antagonist

Glucocorticoid Regulation of Corticotropin-Releasing Factor1 Receptor Expression in Pituitary-Derived AtT-20 Cells

Discovery of Two Clinical Histamine H 3 Receptor Antagonists: trans - N -Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans -3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]- N -(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

The cannabinoid CB(1) receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task

The cannabinoid CB 1 receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task

Role of Corticotropin‐Releasing Factor Receptor‐1 in Opiate Withdrawal

Agonist-induced changes in [Ca 2+] i in N1E-115 cells: differential effects of bradykinin and carbachol

Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2 H -pyrazolo[3,4- f ][1,4]oxazepin-8(5 H )-one (PF-514273), a Novel, Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist for the Treatment of Obesity

Design of a Potent CB 1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents

CP-809,101, a selective 5-HT 2C agonist, shows activity in animal models of antipsychotic activity

Differential regulation of corticotropin-releasing factor1 receptor expression by stress and agonist treatments in brain and cultured cells

Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

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