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Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies?

Advanced science, 2020-11, Vol.7 (22), p.2002030-n/a

Ingber, Donald E.

2020

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Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

Proceedings of the National Academy of Sciences - PNAS, 2016-01, Vol.113 (1), p.E7-E15

2016

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Mechanical control of tissue and organ development

Development (Cambridge), 2010-05, Vol.137 (9), p.1407-1420

2010

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Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

Integrative biology (Cambridge), 2013-09, Vol.5 (9), p.1130-1140

2013

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A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells

Scientific reports, , Vol.4 (1), Article 3896

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Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation

Nature materials, 2015-12, Vol.14 (12), p.1269-1277

2015

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Mechanobiology and Developmental Control

Annual review of cell and developmental biology, 2013-10, Vol.29 (1), p.27-61

2013

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Mechanosensitive mechanisms in transcriptional regulation

Journal of cell science, 2012-07, Vol.125 (Pt 13), p.3061-3073

2012

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Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

PloS one, 2016-03, Vol.11 (3), p.e0150360-e0150360

2016

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Human organs-on-chips for disease modelling, drug development and personalized medicine

Nature reviews. Genetics, 2022-08, Vol.23 (8), p.467

Ingber, Donald E

2022

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Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

Nature communications, 2019-06, Vol.10 (1), p.2621-12, Article 2621

2019

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Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro

PloS one, 2017-02, Vol.12 (2), p.e0169412-e0169412

2017

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Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

Scientific reports, 2018-02, Vol.8 (1), p.2871-14, Article 2871

2018

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Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips

Annual review of pharmacology and toxicology, 2018-01, Vol.58, p.37

2018

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A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

Nature biotechnology, 2018-10, Vol.36 (9), p.865-874

2018

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Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

Cell reports (Cambridge), 2017-10, Vol.21 (2), p.508-516

2017

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Mechanotransduction of fluid stresses governs 3D cell migration

Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (7), p.2447-2452

2014

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Reconstituting Organ-Level Lung Functions on a Chip

Science (American Association for the Advancement of Science), 2010-06, Vol.328 (5986), p.1662-1668

2010

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Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro

Nature methods, 2014-06, Vol.11 (6), p.663

2014

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Simulating drug concentrations in PDMS microfluidic organ chips

Lab on a chip, 2021-09, Vol.21 (18), p.359-3519

2021

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Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape

Nano letters, 2018-06, Vol.18 (6), p.3557-3564

2018

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A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function

Nature communications, 2016-01, Vol.7 (1), p.10176-10176, Article 10176

2016

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Tensegrity II. How structural networks influence cellular information processing networks

Journal of cell science, 2003-04, Vol.116 (Pt 8), p.1397-1408

Ingber, Donald E.

2003

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A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice

Science translational medicine, 2012-11, Vol.4 (159), p.159ra147

2012

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Microfluidic Organ-on-a-Chip Models of Human Intestine

Cellular and molecular gastroenterology and hepatology, 2018-01, Vol.5 (4), p.659-668

2018

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Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies?

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

Mechanical control of tissue and organ development

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells

Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation

Mechanobiology and Developmental Control

Mechanosensitive mechanisms in transcriptional regulation

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

Human organs-on-chips for disease modelling, drug development and personalized medicine

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

Mechanotransduction of fluid stresses governs 3D cell migration

Reconstituting Organ-Level Lung Functions on a Chip

Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro

Simulating drug concentrations in PDMS microfluidic organ chips

Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape

A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function

Tensegrity II. How structural networks influence cellular information processing networks

A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice

Microfluidic Organ-on-a-Chip Models of Human Intestine

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