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PINK1-Parkin signaling in Parkinson’s disease: Lessons from Drosophila

Neuroscience research, 2020-10, Vol.159, p.40-46

Imai, Yuzuru

2020

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Editorial: Molecular links between mitochondrial damage and human neurodegenerative disorders, volume II

Frontiers in cell and developmental biology, 2024, Vol.12, p.1417802-1417802

Imai, Yuzuru

2024

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Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

Nature (London), 2010-07, Vol.466 (7306), p.637-641

2010

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Editorial for the Special Issue "Animal Models of Parkinson's Disease and Related Disorders"

International journal of molecular sciences, 2020-06, Vol.21 (12), p.4250

Imai, Yuzuru

2020

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Lipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson's Disease

International journal of molecular sciences, 2020-05, Vol.21 (9), p.3301

2020

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PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

Scientific reports, 2012-12, Vol.2 (1), p.1002-1002, Article 1002

2012

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Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia

International journal of molecular sciences, 2019-02, Vol.20 (4), p.908

2019

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Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder

Current opinion in neurobiology, 2011-12, Vol.21 (6), p.935-941

2011

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Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

Nature communications, 2017-06, Vol.8 (1), p.15500-15500, Article 15500

2017

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Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria

PLoS genetics, 2012-03, Vol.8 (3), p.e1002537

2012

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High-fat diet–induced activation of SGK1 promotes Alzheimer’s disease–associated tau pathology

Human molecular genetics, 2021-08, Vol.30 (18), p.1693-1710

2021

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PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila

PLoS genetics, 2014-06, Vol.10 (6), p.e1004391-e1004391

2014

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Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy

The EMBO journal, 2018-11, Vol.37 (21), p.n/a

2018

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Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

The EMBO journal, 2008-09, Vol.27 (18), p.2432-2443

2008

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Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering

PLoS genetics, 2014-12, Vol.10 (12), p.e1004861-e1004861

2014

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Is Glial Dysfunction the Key Pathogenesis of LRRK2 -Linked Parkinson's Disease?

Biomolecules (Basel, Switzerland), 2023-01, Vol.13 (1), p.178

2023

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

Proceedings of the National Academy of Sciences - PNAS, 2006-07, Vol.103 (28), p.10793-10798

2006

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Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation

Human molecular genetics, 2022-08, Vol.31 (15), p.2623-2638

2022

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Syntaxin 17, an ancient SNARE paralog, plays different and conserved roles in different organisms

Journal of cell science, 2021-11, Vol.134 (22)

2021

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Clinical Manifestations and Molecular Backgrounds of Parkinson's Disease Regarding Genes Identified From Familial and Population Studies

Frontiers in neurology, 2022-06, Vol.13, p.764917-764917

2022

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Neurodegeneration-associated mitochondrial proteins, CHCHD2 and CHCHD10–what distinguishes the two?

Frontiers in cell and developmental biology, 2022-09, Vol.10, p.996061-996061

2022

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Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease

Stem cell reports, 2020-06, Vol.14 (6), p.1060-1075

2020

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Mitochondrial-Associated Membranes in Parkinson’s Disease

Advances in experimental medicine and biology, 2017-01, Vol.997, p.157-169

2017

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Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity

The Journal of biological chemistry, 2000-11, Vol.275 (46), p.35661-35664

2000

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A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson's Disease Affects LRRK2 Protein Levels

International journal of molecular sciences, 2021-04, Vol.22 (7), p.3708

2021

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PINK1-Parkin signaling in Parkinson’s disease: Lessons from Drosophila

Editorial: Molecular links between mitochondrial damage and human neurodegenerative disorders, volume II

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

Editorial for the Special Issue "Animal Models of Parkinson's Disease and Related Disorders"

Lipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson's Disease

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia

Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder

Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria

High-fat diet–induced activation of SGK1 promotes Alzheimer’s disease–associated tau pathology

PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila

Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering

Is Glial Dysfunction the Key Pathogenesis of LRRK2 -Linked Parkinson's Disease?

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation

Syntaxin 17, an ancient SNARE paralog, plays different and conserved roles in different organisms

Clinical Manifestations and Molecular Backgrounds of Parkinson's Disease Regarding Genes Identified From Familial and Population Studies

Neurodegeneration-associated mitochondrial proteins, CHCHD2 and CHCHD10–what distinguishes the two?

Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease

Mitochondrial-Associated Membranes in Parkinson’s Disease

Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity

A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson's Disease Affects LRRK2 Protein Levels

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