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Human Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design

Drug metabolism and pharmacokinetics, 2006-01, Vol.21 (3), p.173-185

Imai, Teruko

2006

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Esterases Involved in the Rapid Bioconversion of Esmolol after Intravenous Injection in Humans

Biological and Pharmaceutical Bulletin, 2022/10/01, Vol.45(10), pp.1544-1552

2022

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Species Difference of Esterase Expression and Hydrolase Activity in Plasma

Journal of pharmaceutical sciences, 2012-10, Vol.101 (10), p.3979-3988

2012

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Improvement of Pharmaceutical Properties of Zerumbone, a Multifunctional Compound, Using Cyclodextrin Derivatives

Chemical and Pharmaceutical Bulletin, 2020/11/01, Vol.68(11), pp.1117-1120

2020

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The role of intestinal carboxylesterase in the oral absorption of prodrugs

Current drug metabolism, 2010-11, Vol.11 (9), p.793-805

2010

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Identification of Major Esterase Involved in Hydrolysis of Soft Anticholinergic (2R3’R-SGM) Designed From Glycopyrrolate in Human and Rat Tissues

Journal of pharmaceutical sciences, 2019-08, Vol.108 (8), p.2791-2797

2019

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Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies

Biological and Pharmaceutical Bulletin, 2018/05/01, Vol.41(5), pp.697-706

2018

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Identification of esterase involved in the metabolism of two corticosteroid soft drugs

Biochemical pharmacology, 2017-03, Vol.127, p.82-89

2017

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Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine

Drug metabolism and disposition, 2006-10, Vol.34 (10), p.1734-1741

2006

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Effect of Calcium on the Hydrolysis Activity of Human Butyrylcholinesterase

Journal of pharmaceutical sciences, 2020-03, Vol.109 (3), p.1417-1420

2020

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Carboxylesterase in the liver and small intestine of experimental animals and human

Life sciences (1973), 2007-08, Vol.81 (11), p.924-932

2007

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Aspirin hydrolysis in human and experimental animal plasma and the effect of metal cations on hydrolase activities

Drug metabolism and disposition, 2013-07, Vol.41 (7), p.1450-1456

2013

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A novel quantification method for serine hydrolases in cellular expression system using fluorophosphonate-biotin probe

European journal of pharmaceutical sciences, 2018-03, Vol.114, p.267-274

2018

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Development of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat

Xenobiotica, 2019-05, Vol.49 (5), p.569-576

2019

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The Association of the Cholesterol Efflux Capacity with the Paraoxonase 1 Q192R Genotype and the Paraoxonase Activity

Journal of Atherosclerosis and Thrombosis, 2024/09/01, Vol.31(9), pp.1263-1276

2024

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Systematic identification and characterization of carboxylesterases in cynomolgus macaques

Drug metabolism and disposition, 2014-12, Vol.42 (12), p.2002-2006

2014

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Identification and Characterization of a New Carboxylesterase 2 Isozyme, mfCES2C, in the Small Intestine of Cynomolgus Monkeys

Drug metabolism and disposition, 2020-03, Vol.48 (3), p.146-152

2020

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Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine

Drug metabolism and disposition, 2014-02, Vol.42 (2), p.264-273

2014

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Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver

Xenobiotica, 2019-02, Vol.49 (2), p.247-255

2019

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Receptor-destroying enzyme (RDE) from Vibrio cholerae modulates IgE activity and reduces the initiation of anaphylaxis

The Journal of biological chemistry, 2019-04, Vol.294 (17), p.6659-6669

2019

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Prodrug Approach in Current Drug Discovery

Drug metabolism and pharmacokinetics, 2011, Vol.26 (4), p.307-308

Imai, Teruko

2011

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Effect of alcohol on skin permeation and metabolism of an ester-type prodrug in Yucatan micropig skin

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.280-287

2017

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Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques

Journal of Veterinary Medical Science, 2015, Vol.77(6), pp.721-724

2015

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3D-fibroblast tissues constructed by a cell-coat technology enhance tight-junction formation of human colon epithelial cells

Biochemical and biophysical research communications, 2015-02, Vol.457 (3), p.363-369

2015

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Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins

Mammalian genome, 2010-10, Vol.21 (9-10), p.427-441

2010

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Human Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design

Esterases Involved in the Rapid Bioconversion of Esmolol after Intravenous Injection in Humans

Species Difference of Esterase Expression and Hydrolase Activity in Plasma

Improvement of Pharmaceutical Properties of Zerumbone, a Multifunctional Compound, Using Cyclodextrin Derivatives

The role of intestinal carboxylesterase in the oral absorption of prodrugs

Identification of Major Esterase Involved in Hydrolysis of Soft Anticholinergic (2R3’R-SGM) Designed From Glycopyrrolate in Human and Rat Tissues

Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies

Identification of esterase involved in the metabolism of two corticosteroid soft drugs

Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine

Effect of Calcium on the Hydrolysis Activity of Human Butyrylcholinesterase

Carboxylesterase in the liver and small intestine of experimental animals and human

Aspirin hydrolysis in human and experimental animal plasma and the effect of metal cations on hydrolase activities

A novel quantification method for serine hydrolases in cellular expression system using fluorophosphonate-biotin probe

Development of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat

The Association of the Cholesterol Efflux Capacity with the Paraoxonase 1 Q192R Genotype and the Paraoxonase Activity

Systematic identification and characterization of carboxylesterases in cynomolgus macaques

Identification and Characterization of a New Carboxylesterase 2 Isozyme, mfCES2C, in the Small Intestine of Cynomolgus Monkeys

Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine

Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver

Receptor-destroying enzyme (RDE) from Vibrio cholerae modulates IgE activity and reduces the initiation of anaphylaxis

Prodrug Approach in Current Drug Discovery

Effect of alcohol on skin permeation and metabolism of an ester-type prodrug in Yucatan micropig skin

Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques

3D-fibroblast tissues constructed by a cell-coat technology enhance tight-junction formation of human colon epithelial cells

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins

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