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Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases

Molecules (Basel, Switzerland), 2020-04, Vol.25 (8), p.1924

2020

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Protein structure determination by x-ray crystallography

Methods in molecular biology (Clifton, N.J.), 2008, Vol.452, p.63

2008

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Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target

Cancers, 2020-04, Vol.12 (4), p.887

2020

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Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening

PLoS neglected tropical diseases, 2018-11, Vol.12 (11), p.e0006969-e0006969

2018

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Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells

Molecules, 2014-09, Vol.19 (9), p.13976-13989

2014

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The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme

PloS one, 2018-07, Vol.13 (7), p.e0199191-e0199191

2018

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Investigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands

International journal of molecular sciences, 2023-03, Vol.24 (7), p.6367

2023

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Inhibition of Leishmania infantum Trypanothione Reductase by New Aminopropanone Derivatives Interacting with the NADPH Binding Site

Molecules (Basel, Switzerland), 2023-01, Vol.28 (1), p.338

2023

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Huntingtin Ubiquitination Mechanisms and Novel Possible Therapies to Decrease the Toxic Effects of Mutated Huntingtin

Journal of personalized medicine, 2021-12, Vol.11 (12), p.1309

2021

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Engineered ferritin for lanthanide binding

PloS one, 2018-08, Vol.13 (8), p.e0201859-e0201859

2018

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The crystal structures of the tryparedoxin-tryparedoxin peroxidase couple unveil the structural determinants of Leishmania detoxification pathway

PLoS neglected tropical diseases, 2012-08, Vol.6 (8), p.e1781

2012

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Structural basis of Sorcin-mediated calcium-dependent signal transduction

Scientific reports, 2015-11, Vol.5 (1), p.16828-16828, Article 16828

2015

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Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme

PLoS neglected tropical diseases, 2020-05, Vol.14 (5), p.e0008339-e0008339

2020

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Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives

Journal of enzyme inhibition and medicinal chemistry, 2017-01, Vol.32 (1), p.304-310

2017

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Metals and metal derivatives in medicine

Mini reviews in medicinal chemistry, 2013-02, Vol.13 (2), p.211

2013

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Known Drugs Identified by Structure-Based Virtual Screening Are Able to Bind Sigma-1 Receptor and Increase Growth of Huntington Disease Patient-Derived Cells

International journal of molecular sciences, 2021-01, Vol.22 (3), p.1293

2021

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Structural Basis of Enzymatic (S)-Norcoclaurine Biosynthesis

The Journal of biological chemistry, 2009-01, Vol.284 (2), p.897-904

2009

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Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review

Mini reviews in medicinal chemistry, 2015-01, Vol.15 (3), p.243

2015

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Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis

PloS one, 2014-01, Vol.9 (1), p.e85438

2014

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Polyamine metabolism in Leishmania: from arginine to trypanothione

Amino acids, 2011-02, Vol.40 (2), p.269-285

2011

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Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design

Frontiers in molecular biosciences, 2022-07, Vol.9, p.900882-900882

2022

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The Dps Protein of Agrobacterium tumefaciens Does Not Bind to DNA but Protects It toward Oxidative Cleavage

The Journal of biological chemistry, 2003-05, Vol.278 (22), p.20319-20326

2003

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The dodecameric ferritin from Listeria innocua contains a novel intersubunit iron-binding site

Nature structural & molecular biology, 2000-01, Vol.7 (1), p.38-43

2000

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The crystal structure of Giardia duodenalis 14-3-3 in the apo form: when protein post-translational modifications make the difference

PloS one, 2014-03, Vol.9 (3), p.e92902

2014

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Iron Incorporation into Escherichia coli Dps Gives Rise to a Ferritin-like Microcrystalline Core

The Journal of biological chemistry, 2002-10, Vol.277 (40), p.37619-37623

2002

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Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases

Protein structure determination by x-ray crystallography

Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening

Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells

The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme

Investigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands

Inhibition of Leishmania infantum Trypanothione Reductase by New Aminopropanone Derivatives Interacting with the NADPH Binding Site

Huntingtin Ubiquitination Mechanisms and Novel Possible Therapies to Decrease the Toxic Effects of Mutated Huntingtin

Engineered ferritin for lanthanide binding

The crystal structures of the tryparedoxin-tryparedoxin peroxidase couple unveil the structural determinants of Leishmania detoxification pathway

Structural basis of Sorcin-mediated calcium-dependent signal transduction

Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme

Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives

Metals and metal derivatives in medicine

Known Drugs Identified by Structure-Based Virtual Screening Are Able to Bind Sigma-1 Receptor and Increase Growth of Huntington Disease Patient-Derived Cells

Structural Basis of Enzymatic (S)-Norcoclaurine Biosynthesis

Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review

Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis

Polyamine metabolism in Leishmania: from arginine to trypanothione

Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design

The Dps Protein of Agrobacterium tumefaciens Does Not Bind to DNA but Protects It toward Oxidative Cleavage

The dodecameric ferritin from Listeria innocua contains a novel intersubunit iron-binding site

The crystal structure of Giardia duodenalis 14-3-3 in the apo form: when protein post-translational modifications make the difference

Iron Incorporation into Escherichia coli Dps Gives Rise to a Ferritin-like Microcrystalline Core

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