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Bromocriptine Mesylate Attenuates Amyotrophic Lateral Sclerosis: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Research in Japanese Patients

PloS one, 2016-02, Vol.11 (2), p.e0149509

2016

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A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection

PloS one, 2017-10, Vol.12 (10), p.e0186227-e0186227

2017

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Neuronal apoptosis inhibitory protein is implicated in amyotrophic lateral sclerosis symptoms

Scientific reports, 2018-01, Vol.8 (1), p.6-6, Article 6

2018

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Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking

PloS one, 2010-03, Vol.5 (3), p.e9805

2010

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A novel acylaminoimidazole derivative, WN1316, alleviates disease progression via suppression of glial inflammation in ALS mouse model

PloS one, 2014-01, Vol.9 (1), p.e87728-e87728

2014

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The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis

The Journal of biological chemistry, 2007-06, Vol.282 (22), p.16599-16611

2007

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Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis

Experimental neurology, 2011-11, Vol.232 (1), p.41-52

2011

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Correction: Bromocriptine Mesylate Attenuates Amyotrophic Lateral Sclerosis: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Research in Japanese Patients

PloS one, 2016-03, Vol.11 (3), p.e0152845-e0152845

2016

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Molecular and cellular function of ALS2/alsin: Implication of membrane dynamics in neuronal development and degeneration

Neurochemistry international, 2007-07, Vol.51 (2), p.74-84

2007

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ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth

Biochemical and biophysical research communications, 2008-05, Vol.370 (1), p.87-92

2008

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Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking

Human molecular genetics, 2006-01, Vol.15 (2), p.233-250

2006

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Cyclin-Dependent Kinases as a Therapeutic Target for Stroke

Proceedings of the National Academy of Sciences - PNAS, 2000-08, Vol.97 (18), p.10254-10259

2000

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A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2–ARE pathway: Therapeutic implications for ALS

Free radical biology & medicine, 2012-12, Vol.53 (11), p.2028-2042

2012

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Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation

FEBS letters, 2011-03, Vol.585 (5), p.730-736

2011

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Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice

Neuroscience research, 2010-10, Vol.68 (2), p.131-136

2010

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Novel Nuclear Shuttle Proteins, HDBP1 and HDBP2, Bind to Neuronal Cell-specific cis-Regulatory Element in the Promoter for the Human Huntington's Disease Gene

The Journal of biological chemistry, 2004-02, Vol.279 (8), p.7275-7286

2004

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Homo-oligomerization of ALS2 through Its Unique Carboxyl-terminal Regions Is Essential for the ALS2-associated Rab5 Guanine Nucleotide Exchange Activity and Its Regulatory Function on Endosome Trafficking

The Journal of biological chemistry, 2004-09, Vol.279 (37), p.38626-38635

2004

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Inhibition of Cyclin-Dependent Kinases Improves CA1 Neuronal Survival and Behavioral Performance After Global Ischemia in the Rat

Journal of cerebral blood flow and metabolism, 2002-02, Vol.22 (2), p.171-182

2002

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ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics

Biochemical and biophysical research communications, 2007-03, Vol.354 (2), p.491-497

2007

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Morphodynamics of ovarian follicles during oogenesis in mice

Microscopy research and technique, 2006-06, Vol.69 (6), p.427-435

2006

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The structures of integration sites in transgenic rice

The Plant journal : for cell and molecular biology, 1997-03, Vol.11 (3), p.353-361

1997

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ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics

FEBS letters, 2004-09, Vol.575 (1), p.64-70

2004

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A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein

Journal of cerebral blood flow and metabolism, 2005-07, Vol.25 (7), p.794-806

2005

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A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

Nature genetics, 2001-10, Vol.29 (2), p.166-173

2001

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Production of transgenic miniature pigs by pronuclear microinjection

Transgenic research, 2001-12, Vol.10 (6), p.577-582

2001

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Bromocriptine Mesylate Attenuates Amyotrophic Lateral Sclerosis: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Research in Japanese Patients

A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection

Neuronal apoptosis inhibitory protein is implicated in amyotrophic lateral sclerosis symptoms

Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking

A novel acylaminoimidazole derivative, WN1316, alleviates disease progression via suppression of glial inflammation in ALS mouse model

The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis

Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis

Correction: Bromocriptine Mesylate Attenuates Amyotrophic Lateral Sclerosis: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Research in Japanese Patients

Molecular and cellular function of ALS2/alsin: Implication of membrane dynamics in neuronal development and degeneration

ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth

Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking

Cyclin-Dependent Kinases as a Therapeutic Target for Stroke

A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2–ARE pathway: Therapeutic implications for ALS

Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation

Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice

Novel Nuclear Shuttle Proteins, HDBP1 and HDBP2, Bind to Neuronal Cell-specific cis-Regulatory Element in the Promoter for the Human Huntington's Disease Gene

Homo-oligomerization of ALS2 through Its Unique Carboxyl-terminal Regions Is Essential for the ALS2-associated Rab5 Guanine Nucleotide Exchange Activity and Its Regulatory Function on Endosome Trafficking

Inhibition of Cyclin-Dependent Kinases Improves CA1 Neuronal Survival and Behavioral Performance After Global Ischemia in the Rat

ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics

Morphodynamics of ovarian follicles during oogenesis in mice

The structures of integration sites in transgenic rice

ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics

A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

Production of transgenic miniature pigs by pronuclear microinjection

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