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The “Metabolic Memory”: Is More Than Just Tight Glucose Control Necessary to Prevent Diabetic Complications?

The journal of clinical endocrinology and metabolism, 2009-02, Vol.94 (2), p.410-415

2009

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Oscillating Glucose Is More Deleterious to Endothelial Function and Oxidative Stress Than Mean Glucose in Normal and Type 2 Diabetic Patients

Diabetes (New York, N.Y.), 2008-05, Vol.57 (5), p.1349-1354

2008

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TNF-Alpha as an Initiator of Allodynia and Anxiety-Like Behaviors in a Preclinical Model of PTSD and Comorbid Pain

Frontiers in psychiatry, 2021-08, Vol.12, p.721999-721999

2021

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Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression

PloS one, 2014-05, Vol.9 (5), p.e98624-e98624

2014

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Exploration of a Large Virtual Chemical Space: Identification of Potent Inhibitors of Lactate Dehydrogenase‑A against Pancreatic Cancer

Journal of chemical information and modeling, 2023-02, Vol.63 (3), p.1028-1043

2023

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Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells

Cancer research (Chicago, Ill.), 2010-03, Vol.70 (6), p.2445-2454

2010

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Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents

Bioorganic & medicinal chemistry letters, 2021-06, Vol.41, p.127923-127923, Article 127923

2021

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AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization

Cancer letters, 2017-03, Vol.388, p.149-157

2017

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Innovative Approaches in the Battle Against Cancer Recurrence: Novel Strategies to Combat Dormant Disseminated Tumor Cells

Frontiers in oncology, 2021-04, Vol.11, p.659963-659963

2021

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Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents

Bioorganic & medicinal chemistry letters, 2017-04, Vol.27 (7), p.1602-1607

2017

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Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer

European journal of medicinal chemistry, 2024-09, Vol.275, p.116598, Article 116598

2024

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The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity

Bioorganic & medicinal chemistry, 2021-01, Vol.29, p.115887-115887, Article 115887

2021

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Chronic Exposure to Arsenic in the Drinking Water Alters the Expression of Immune Response Genes in Mouse Lung

Environmental health perspectives, 2009-07, Vol.117 (7), p.1108-1115

2009

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Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents

Bioorganic & medicinal chemistry, 2017-01, Vol.25 (2), p.545-556

2017

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Intraretinal Leakage and Oxidation of LDL in Diabetic Retinopathy

Investigative ophthalmology & visual science, 2008-06, Vol.49 (6), p.2679-2685

2008

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Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: a model for tumor cell "dormancy"

PloS one, 2013-05, Vol.8 (5), p.e64181-e64181

2013

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Targeting dormant micrometastases: rationale, evidence to date and clinical implications

Therapeutic Advances in Medical Oncology, 2016-03, Vol.8 (2), p.126-137

2016

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Interleukin (IL)‐6 modulates transforming growth factor‐β receptor I and II (TGF‐βRI and II) function in epidermal keratinocytes

Experimental dermatology, 2017-08, Vol.26 (8), p.697-704

2017

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A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer

The Journal of pharmacology and experimental therapeutics, 2015-05, Vol.353 (2), p.392-404

2015

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3D Spheroids of Human Primary Urine-Derived Stem Cells in the Assessment of Drug-Induced Mitochondrial Toxicity

Pharmaceutics, 2022-05, Vol.14 (5), p.1042

2022

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Transition from androgenic to neurosteroidal action of 5α-androstane-3α, 17β-diol through the type A γ-aminobutyric acid receptor in prostate cancer progression

The Journal of steroid biochemistry and molecular biology, 2018-04, Vol.178, p.89-98

2018

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Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors

American journal of translational research, 2014-01, Vol.6 (3), p.236-247

2014

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Precision nephrotoxicity testing using 3D in vitro models

Cell & bioscience, 2023-12, Vol.13 (1), p.231-231, Article 231

2023

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Silk fibers assisted long-term 3D culture of human primary urinary stem cells via inhibition of senescence-associated genes: Potential use in the assessment of chronic mitochondrial toxicity

Materials today advances, 2022-08, Vol.15, p.100261, Article 100261

2022

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Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents

Bioorganic & medicinal chemistry, 2010-05, Vol.18 (10), p.3575-3587

2010

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The “Metabolic Memory”: Is More Than Just Tight Glucose Control Necessary to Prevent Diabetic Complications?

Oscillating Glucose Is More Deleterious to Endothelial Function and Oxidative Stress Than Mean Glucose in Normal and Type 2 Diabetic Patients

TNF-Alpha as an Initiator of Allodynia and Anxiety-Like Behaviors in a Preclinical Model of PTSD and Comorbid Pain

Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression

Exploration of a Large Virtual Chemical Space: Identification of Potent Inhibitors of Lactate Dehydrogenase‑A against Pancreatic Cancer

Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells

Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents

AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization

Innovative Approaches in the Battle Against Cancer Recurrence: Novel Strategies to Combat Dormant Disseminated Tumor Cells

Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents

Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer

The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity

Chronic Exposure to Arsenic in the Drinking Water Alters the Expression of Immune Response Genes in Mouse Lung

Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents

Intraretinal Leakage and Oxidation of LDL in Diabetic Retinopathy

Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: a model for tumor cell "dormancy"

Targeting dormant micrometastases: rationale, evidence to date and clinical implications

Interleukin (IL)‐6 modulates transforming growth factor‐β receptor I and II (TGF‐βRI and II) function in epidermal keratinocytes

A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer

3D Spheroids of Human Primary Urine-Derived Stem Cells in the Assessment of Drug-Induced Mitochondrial Toxicity

Transition from androgenic to neurosteroidal action of 5α-androstane-3α, 17β-diol through the type A γ-aminobutyric acid receptor in prostate cancer progression

Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors

Precision nephrotoxicity testing using 3D in vitro models

Silk fibers assisted long-term 3D culture of human primary urinary stem cells via inhibition of senescence-associated genes: Potential use in the assessment of chronic mitochondrial toxicity

Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents

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