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Dynamic and Static Simulations of Fluvoxamine-Perpetrated Drug-Drug Interactions Using Multiple Cytochrome P450 Inhibition Modeling, and Determination of Perpetrator-Specific CYP Isoform Inhibition Constants and Fractional CYP Isoform Contributions to Victim Clearance

Journal of pharmaceutical sciences, 2016-03, Vol.105 (3), p.1307-1317

Iga, Katsumi

2016

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Simulation of Metabolic Drug-Drug Interactions Perpetrated by Fluvoxamine Using Hybridized Two-Compartment Hepatic Drug-Pool-Based Tube Modeling and Estimation of In Vivo Inhibition Constants

Journal of pharmaceutical sciences, 2015-10, Vol.104 (10), p.3565-3577

Iga, Katsumi

2015

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Use of Three-Compartment Physiologically Based Pharmacokinetic Modeling to Predict Hepatic Blood Levels of Fluvoxamine Relevant for Drug-Drug Interactions

Journal of pharmaceutical sciences, 2015-04, Vol.104 (4), p.1478-1491

Iga, Katsumi

2015

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Usefulness of Two-Compartment Model-Assisted and Static Overall Inhibitory-Activity Method for Prediction of Drug–Drug Interaction

Biological and Pharmaceutical Bulletin, 2017/12/01, Vol.40(12), pp.2024-2037

2017

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Simulations of Cytochrome P450 3A4-Mediated Drug-Drug Interactions by Simple Two-Compartment Model-Assisted Static Method

Journal of pharmaceutical sciences, 2017-05, Vol.106 (5), p.1426-1438

2017

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Novel Strategy for the Systemic Delivery of Furosemide Based on a New Drug Transport Mechanism

Biological and Pharmaceutical Bulletin, 2018/12/01, Vol.41(12), pp.1769-1777

2018

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Interplay of UDP-Glucuronosyltransferase and CYP2C8 for CYP2C8 Mediated Drug Oxidation and Its Impact on Drug-Drug Interaction Produced by Standardized CYP2C8 Inhibitors, Clopidogrel

Clinical pharmacokinetics, 2024-01, Vol.63 (1), p.43-56

2024

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Interplay of UDP-Glucuronosyltransferase and CYP2C8 for CYP2C8 Mediated Drug Oxidation and Its Impact on Drug–Drug Interaction Produced by Standardized CYP2C8 Inhibitors, Clopidogrel and Gemfibrozil

Clinical pharmacokinetics, 2024, Vol.63 (1), p.43-56

2024

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Verification of Pharmacokinetic Approaches in Prior Drug Development

YAKUGAKU ZASSHI, 2019/03/01, Vol.139(3), pp.437-460

Iga, Katsumi

2019

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Dynamic and Static Simulations of Fluvoxamine-Perpetrated Drug-Drug Interactions Using Multiple Cytochrome P450 Inhibition Modeling, and Determination of Perpetrator-Specific CYP Isoform Inhibition Constants and Fractional CYP Isoform Contributions to Victim Clearance: Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism

Journal of pharmaceutical sciences, 2016-03, Vol.105 (3), p.1307-1317

Iga, Katsumi

2016

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Pharmacokinetic-pharmacodynamic analyses of antihypertensive drugs, nifedipine and propranolol, in spontaneously hypertensive rats to investigate characteristics of effect and side effects

Regulatory toxicology and pharmacology, 2016-04, Vol.76, p.21-29

2016

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Novel strategy for improving the bioavailability of curcumin based on a new membrane transport mechanism that directly involves solid particles

European journal of pharmaceutics and biopharmaceutics, 2018-01, Vol.122, p.1-5

2018

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Availability of polymeric nanoparticles for specific enhanced and targeted drug delivery

Therapeutic delivery, 2013-10, Vol.4 (10), p.1261-1278

2013

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Novel Strategy for the Systemic Delivery of Furosemide Based on a New Drug Transport Mechanism

Biological and Pharmaceutical Bulletin, 2018-12, Vol.41 (12), p.1769-1777

2018

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過去の新薬開発における薬物動態学的アプローチに対する検証

YAKUGAKU ZASSHI, 2019/03/01, Vol.139(3), pp.437-460

伊賀, 勝美

2019

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Intrinsic cell permeability of the GAGA zinc finger protein into HeLa cells

Biochemical and biophysical research communications, 2015-09, Vol.464 (4), p.1034-1039

2015

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Effects of physiological and biochemical factors based on aging, pathological conditions and drug combinations on propranolol pharmacokinetics using physiologically-based pharmacokinetic model in humans

Biomedicine & aging pathology, 2013-07, Vol.3 (3), p.107-114

2013

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Binding of Multivalent Anionic Porphyrins to V3 Loop Fragments of an HIV-1 Envelope and Their Antiviral Activity

Chemistry, an Asian journal, 2010-04, Vol.5 (4), p.825-834

2010

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Increased Tumor Cisplatin Levels in Heated Tumors in Mice after Administration of Thermosensitive, Large Unilamellar Vesicles Encapsulating Cisplatin

Journal of pharmaceutical sciences, 1991-06, Vol.80 (6), p.522-525

1991

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Novel sustained-release dosage forms of proteins using polyglycerol esters of fatty acids

Journal of controlled release, 2000-02, Vol.63 (3), p.319-329

2000

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Prevention of bone loss in ovariectomized rats by pulsatile transdermal iontophoretic administration of human PTH(1–34)

Journal of pharmaceutical sciences, 2002-02, Vol.91 (2), p.350-361

2002

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Iontophoretic pulsatile transdermal delivery of human parathyroid hormone (1-34)

Journal of pharmacy and pharmacology, 2001-09, Vol.53 (9), p.1227-1234

2001

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Sustained-release buccal dosage forms for nitroglycerin and isosorbide dinitrate: increased bioavailability and extended time of absorption when administered to dogs

Journal of controlled release, 1997-12, Vol.49 (2), p.105-113

1997

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Effects of physiological factors on the bioavailability of ethyl 2-chloro-3-(4-(2-methyl-2-phenyl-propyloxy) phenyl) propionate in an emulsion in rats

Chemical & pharmaceutical bulletin, 1990, Vol.38 (10), p.2801-2804

1990

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Gastro-intestinal absorption of ethyl 2-chloro-3-(4-(2-methyl-2-phenylpropyloxy)phenyl) propionate from different dosage forms in rats and dogs

Chemical & pharmaceutical bulletin, 1990, Vol.38 (10), p.2792-2796

1990

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Dynamic and Static Simulations of Fluvoxamine-Perpetrated Drug-Drug Interactions Using Multiple Cytochrome P450 Inhibition Modeling, and Determination of Perpetrator-Specific CYP Isoform Inhibition Constants and Fractional CYP Isoform Contributions to Victim Clearance

Simulation of Metabolic Drug-Drug Interactions Perpetrated by Fluvoxamine Using Hybridized Two-Compartment Hepatic Drug-Pool-Based Tube Modeling and Estimation of In Vivo Inhibition Constants

Use of Three-Compartment Physiologically Based Pharmacokinetic Modeling to Predict Hepatic Blood Levels of Fluvoxamine Relevant for Drug-Drug Interactions

Usefulness of Two-Compartment Model-Assisted and Static Overall Inhibitory-Activity Method for Prediction of Drug–Drug Interaction

Simulations of Cytochrome P450 3A4-Mediated Drug-Drug Interactions by Simple Two-Compartment Model-Assisted Static Method

Novel Strategy for the Systemic Delivery of Furosemide Based on a New Drug Transport Mechanism

Interplay of UDP-Glucuronosyltransferase and CYP2C8 for CYP2C8 Mediated Drug Oxidation and Its Impact on Drug-Drug Interaction Produced by Standardized CYP2C8 Inhibitors, Clopidogrel

Interplay of UDP-Glucuronosyltransferase and CYP2C8 for CYP2C8 Mediated Drug Oxidation and Its Impact on Drug–Drug Interaction Produced by Standardized CYP2C8 Inhibitors, Clopidogrel and Gemfibrozil

Verification of Pharmacokinetic Approaches in Prior Drug Development

Pharmacokinetic-pharmacodynamic analyses of antihypertensive drugs, nifedipine and propranolol, in spontaneously hypertensive rats to investigate characteristics of effect and side effects

Novel strategy for improving the bioavailability of curcumin based on a new membrane transport mechanism that directly involves solid particles

Availability of polymeric nanoparticles for specific enhanced and targeted drug delivery

Novel Strategy for the Systemic Delivery of Furosemide Based on a New Drug Transport Mechanism

過去の新薬開発における薬物動態学的アプローチに対する検証

Intrinsic cell permeability of the GAGA zinc finger protein into HeLa cells

Effects of physiological and biochemical factors based on aging, pathological conditions and drug combinations on propranolol pharmacokinetics using physiologically-based pharmacokinetic model in humans

Binding of Multivalent Anionic Porphyrins to V3 Loop Fragments of an HIV-1 Envelope and Their Antiviral Activity

Increased Tumor Cisplatin Levels in Heated Tumors in Mice after Administration of Thermosensitive, Large Unilamellar Vesicles Encapsulating Cisplatin

Novel sustained-release dosage forms of proteins using polyglycerol esters of fatty acids

Prevention of bone loss in ovariectomized rats by pulsatile transdermal iontophoretic administration of human PTH(1–34)

Iontophoretic pulsatile transdermal delivery of human parathyroid hormone (1-34)

Sustained-release buccal dosage forms for nitroglycerin and isosorbide dinitrate: increased bioavailability and extended time of absorption when administered to dogs

Effects of physiological factors on the bioavailability of ethyl 2-chloro-3-(4-(2-methyl-2-phenyl-propyloxy) phenyl) propionate in an emulsion in rats

Gastro-intestinal absorption of ethyl 2-chloro-3-(4-(2-methyl-2-phenylpropyloxy)phenyl) propionate from different dosage forms in rats and dogs

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