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AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

Annual review of pharmacology and toxicology, 2012-01, Vol.52 (1), p.381-400

2012

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AMPK directly activates mTORC2 to promote cell survival during acute energetic stress

Science signaling, 2019-06, Vol.12 (585)

2019

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LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

eLife, 2017-06, Vol.6

2017

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Role of TSC–mTOR pathway in diabetic nephropathy

Diabetes research and clinical practice, 2008-11, Vol.82, p.S59-S62

Inoki, Ken

2008

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ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity

Blood, 2020-12, Vol.136 (26), p.2975-2986

2020

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mTOR Signaling in Autophagy Regulation in the Kidney

Seminars in nephrology, 2014-01, Vol.34 (1), p.2-8

Inoki, Ken, MD, PhD

2014

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Growth factor signaling to mTORC1 by amino acid-laden macropinosomes

The Journal of cell biology, 2015-10, Vol.211 (1), p.159-172

2015

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PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity

Molecular biology of the cell, 2022-03, Vol.33 (3), p.ar26-ar26

2022

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

Genes & development, 2006-10, Vol.20 (20), p.2820-2832

2006

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Dysregulation of the TSC-mTOR pathway in human disease

Nature genetics, 2005-01, Vol.37 (1), p.19-24

2005

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Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

PLoS biology, 2019-05, Vol.17 (5), p.e3000252-e3000252

2019

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Inhibition of AMPK Catabolic Action by GSK3

Molecular cell, 2013-05, Vol.50 (3), p.407-419

2013

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Genes & development, 2003-08, Vol.17 (15), p.1829-1834

2003

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SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes

The Journal of clinical investigation, 2023-03, Vol.133 (5)

2023

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Liver Clock Protein BMAL1 Promotes de Novo Lipogenesis through Insulin-mTORC2-AKT Signaling

The Journal of biological chemistry, 2014-09, Vol.289 (37), p.25925-25935

2014

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mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

Aging cell, 2019-06, Vol.18 (3), p.e12943-n/a

2019

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Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

Science (American Association for the Advancement of Science), 2011-05, Vol.332 (6032), p.966-970

2011

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Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity

Molecular cell, 2020-11, Vol.80 (3), p.437-451.e6

2020

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Proceedings of the National Academy of Sciences - PNAS, 2010-03, Vol.107 (9), p.4153-4158

2010

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Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells

Biomolecules (Basel, Switzerland), 2017-07, Vol.7 (3), p.51

2017

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Cross-talk between Sirtuin and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in the Regulation of S6 Kinase 1 (S6K1) Phosphorylation

The Journal of biological chemistry, 2014-05, Vol.289 (19), p.13132-13141

2014

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mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

The Journal of clinical investigation, 2011-06, Vol.121 (6), p.2181-2196

2011

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Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

The Journal of clinical investigation, 2011-06, Vol.121 (6), p.2197-2209

2011

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Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress

Cell reports (Cambridge), 2017-07, Vol.20 (4), p.895-908

2017

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Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1

Molecular biology of the cell, 2012-08, Vol.23 (15), p.2955-2962

2012

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AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

AMPK directly activates mTORC2 to promote cell survival during acute energetic stress

LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

Role of TSC–mTOR pathway in diabetic nephropathy

ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity

mTOR Signaling in Autophagy Regulation in the Kidney

Growth factor signaling to mTORC1 by amino acid-laden macropinosomes

PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

Dysregulation of the TSC-mTOR pathway in human disease

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

Inhibition of AMPK Catabolic Action by GSK3

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes

Liver Clock Protein BMAL1 Promotes de Novo Lipogenesis through Insulin-mTORC2-AKT Signaling

mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells

Cross-talk between Sirtuin and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in the Regulation of S6 Kinase 1 (S6K1) Phosphorylation

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1

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