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Synthesis and Angiotensin II Receptor Antagonistic Activities of Benzimidazole Derivatives Bearing Acidic Heterocycles as Novel Tetrazole Bioisosteres

Journal of medicinal chemistry, 1996-12, Vol.39 (26), p.5228-5235

1996

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Blockade of constitutively activated ERK signaling enhances cytotoxicity of microtubule-destabilizing agents in tumor cells

Biochemical and biophysical research communications, 2009-01, Vol.378 (3), p.650-655

2009

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Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids

Journal of medicinal chemistry, 1993-08, Vol.36 (16), p.2343-2349

1993

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Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids

Journal of medicinal chemistry, 1993-07, Vol.36 (15), p.2182-2195

1993

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Inhibition of rabbit aortic angiotensin II (AII) receptor by CV-11974, a new nonpeptide AII antagonist

Biochemical pharmacology, 1993-07, Vol.46 (2), p.311-318

1993

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Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazoles

Journal of medicinal chemistry, 1993-06, Vol.36 (12), p.1772-1784

1993

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Contribution of renal angiotensin II type I receptor to gene expressions in hypertension-induced renal injury

Kidney international, 1994-11, Vol.46 (5), p.1346-1358

1994

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Angiotensin II receptor blocker: Candesartan cilexetil

Journal of Pharmacological Sciences, 2005, Vol.97 (suppl.1), p.35-35

Yoshiyuki Inada

2005

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Angiotensin II receptor blocker: Candesartan cilexetil

Journal of Pharmacological Sciences, 2005, Vol.97 (suppl.1), p.35-35

Yoshiyuki Inada

2005

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CV-3988 - A specific antagonist of platelet activating factor (PAF)

Life sciences (1973), 1983-04, Vol.32 (17), p.1975-1982

1983

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Effect of an angiotensin II receptor antagonist, CV-11974, and its prodrug, TCV-116, on production of aldosterone

European journal of pharmacology, 1994-02, Vol.253 (1), p.27-34

1994

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Candesartan (CV-11974) dissociates slowly from the angiotensin AT1 receptor

European journal of pharmacology, 1997-01, Vol.319 (1), p.137-146

1997

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Combined Effects of the Angiotensin II Antagonist Candesartan Cilexetil (TCV-116) and Other Classes of Antihypertensive Drugs in Spontaneously Hypertensive Rats

Hypertension Research, 1996, Vol.19(4), pp.247-254

1996

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Candesartan cilexetil : pharmacological properties and protective effects against organ damage of a novel nonpeptide angiotensin II-receptor antagonist

Folia Pharmacologica Japonica, 2000/03/01, Vol.115(3), pp.151-160

2000

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Comparison of the Antihypertensive Effects of the New Angiotensin II (AT1) Receptor Antagonist Candesartan Cilexetil (TCV-116) and the Angiotensin Converting Enzyme Inhibitor Enalapril in Rats

Hypertension Research, 1996, Vol.19(2), pp.75-81

1996

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Synthesis and thromboxane A2/prostaglandin H2 receptor antagonistic activity of phenol derivatives

Journal of medicinal chemistry, 1992-06, Vol.35 (12), p.2202-2209

1992

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Candesartan (CV-11974) dissociates slowly from the angiotensin AT1 receptor

European journal of pharmacology, 1997, Vol.319 (1), p.137-146

1997

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Anti-hypertensive Effect of Oral Controlled-release Microspheres Containing an ACE Inhibitor (Delapril Hydrochloride) in Rats

Journal of pharmacy and pharmacology, 1994-08, Vol.46 (8), p.661-665

1994

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Evaluation and improvement of bioavailability of a new angiotensin II receptor antagonist, 2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl] methyl-1H-benzimidazole-7-carboxylic acid by making prodrug

International journal of pharmaceutics, 1994-02, Vol.103 (1), p.1-7

1994

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Role of Angiotensin II in Renal Injury of Deoxycorticosterone Acetate-Salt Hypertensive Rats

Hypertension (Dallas, Tex. 1979), 1994-08, Vol.24 (2), p.195-204

1994

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Synthesis and Angiotensin Converting Enzyme Inhibitory Activity of 1, 5-Benzothiazepine and 1, 5-Benzoxazepine Derivatives. I

Chemical and Pharmaceutical Bulletin, 1986/03/25, Vol.34(3), pp.1128-1147

1986

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Synthesis and Angiotensin Converting Enzyme-Inhibitory Activity of N-((1S)-1-Carboxy-5-(4-piperidyl)pentyl)-L-alanine Derivatives

Chemical & pharmaceutical bulletin, 1994, Vol.42 (3), p.580-585

1994

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Role of angiotensin II in cerebrovascular and renal damage in deoxycorticosterone acetate-salt hypertensive rats

Journal of hypertension, 1995-01, Vol.13 (1), p.113-122

1995

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Pharmacologic properties of candesartan cilexetil-possible mechanisms of long-acting antihypertensive action

Journal of human hypertension, 1999, Vol.13 (S1), p.S75-S80

1999

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Angiotensin-II-stimulated release of thromboxane A2 and prostacyclin (PGI2) in isolated, perfused kidneys of spontaneously hypertensive rats

Biochemical pharmacology, 1979-12, Vol.28 (24), p.3601-3609

1979

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Synthesis and Angiotensin II Receptor Antagonistic Activities of Benzimidazole Derivatives Bearing Acidic Heterocycles as Novel Tetrazole Bioisosteres

Blockade of constitutively activated ERK signaling enhances cytotoxicity of microtubule-destabilizing agents in tumor cells

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids

Inhibition of rabbit aortic angiotensin II (AII) receptor by CV-11974, a new nonpeptide AII antagonist

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazoles

Contribution of renal angiotensin II type I receptor to gene expressions in hypertension-induced renal injury

Angiotensin II receptor blocker: Candesartan cilexetil

Angiotensin II receptor blocker: Candesartan cilexetil

CV-3988 - A specific antagonist of platelet activating factor (PAF)

Effect of an angiotensin II receptor antagonist, CV-11974, and its prodrug, TCV-116, on production of aldosterone

Candesartan (CV-11974) dissociates slowly from the angiotensin AT1 receptor

Combined Effects of the Angiotensin II Antagonist Candesartan Cilexetil (TCV-116) and Other Classes of Antihypertensive Drugs in Spontaneously Hypertensive Rats

Candesartan cilexetil : pharmacological properties and protective effects against organ damage of a novel nonpeptide angiotensin II-receptor antagonist

Comparison of the Antihypertensive Effects of the New Angiotensin II (AT1) Receptor Antagonist Candesartan Cilexetil (TCV-116) and the Angiotensin Converting Enzyme Inhibitor Enalapril in Rats

Synthesis and thromboxane A2/prostaglandin H2 receptor antagonistic activity of phenol derivatives

Candesartan (CV-11974) dissociates slowly from the angiotensin AT1 receptor

Anti-hypertensive Effect of Oral Controlled-release Microspheres Containing an ACE Inhibitor (Delapril Hydrochloride) in Rats

Evaluation and improvement of bioavailability of a new angiotensin II receptor antagonist, 2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl] methyl-1H-benzimidazole-7-carboxylic acid by making prodrug

Role of Angiotensin II in Renal Injury of Deoxycorticosterone Acetate-Salt Hypertensive Rats

Synthesis and Angiotensin Converting Enzyme Inhibitory Activity of 1, 5-Benzothiazepine and 1, 5-Benzoxazepine Derivatives. I

Synthesis and Angiotensin Converting Enzyme-Inhibitory Activity of N-((1S)-1-Carboxy-5-(4-piperidyl)pentyl)-L-alanine Derivatives

Role of angiotensin II in cerebrovascular and renal damage in deoxycorticosterone acetate-salt hypertensive rats

Pharmacologic properties of candesartan cilexetil-possible mechanisms of long-acting antihypertensive action

Angiotensin-II-stimulated release of thromboxane A2 and prostacyclin (PGI2) in isolated, perfused kidneys of spontaneously hypertensive rats

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